Strain Name:
C57BL/6J-MtgxR6862Btlr/Mmmh
Stock Number:
045026-MU
Citation ID:
RRID:MMRRC_045026-MU
Other Names:
R6862 (G1)
Major Collection:

Strain Information

Tk1
Name: thymidine kinase 1
Synonyms: Tk-1, D530002A18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21877
Homologene: 37749
Hdgfl2
Name: HDGF like 2
Synonyms: HRP-2, Hdgfrp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15193
VEGA: 17
Homologene: 7355
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Nacc1
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: 4930511N13Rik, Nac1, Btbd14b, 2010001H03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66830
VEGA: 8
Homologene: 12042
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, ASC1p200, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: trichorhinophalangeal syndrome I (human), D15Ertd586e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Crot
Name: carnitine O-octanoyltransferase
Synonyms: 1200003H03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74114
HGNC: HGNC:2366
Homologene: 10899
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 2900054P12Rik, Gcap14, 1700012P13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, crf11, eyes2, QBRICK
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Prr14l
Name: proline rich 14-like
Synonyms: C330019G07Rik, 6030436E02Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: 5730403H17Rik, Rich1, Nadrin2, WBP15, Nadrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70497
Homologene: 9984
Il22
Name: interleukin 22
Synonyms: IL-22, IL-TIF, Iltif
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50929
Homologene: 9669
Fbxw4
Name: F-box and WD-40 domain protein 4
Synonyms: Fbw4, dactylyn, dactylin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 30838
Homologene: 32197
Zbed5
Name: zinc finger BED-type containing 5
Synonyms: 2410018M08Rik, Chchd2l, Zbed5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71970
Homologene: 84838
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Aff3
Name: AF4/FMR2 family, member 3
Synonyms: LAF-4, Laf4, 3222402O04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16764
HGNC: HGNC:6473
Homologene: 1718
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, Shn-2, MIBP1, Schnurri-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
4930579F01Rik
Name: RIKEN cDNA 4930579F01 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67741
Homologene: 12962
Pdlim4
Name: PDZ and LIM domain 4
Synonyms: Ril
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30794
Homologene: 2735
Garin3
Name: golgi associated RAB2 interactor 3
Synonyms: OTTMUSG00000005491, Fam71b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432552
Homologene: 51067
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, Sne, sy
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Cct6b
Name: chaperonin containing TCP1 subunit 6B
Synonyms: Cctz-2, CCTzeta-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12467
HGNC: HGNC:1621
Homologene: 55978
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Or13c3
Name: olfactory receptor family 13 subfamily C member 3
Synonyms: GA_x6K02T2N78B-7137430-7138383, MOR262-8, Olfr273
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258821
Homologene: 73999
Gsdme
Name: gasdermin E
Synonyms: Dfna5h, Dfna5, 4932441K13Rik, Fin15, 2310037D07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
Tmem208
Name: transmembrane protein 208
Synonyms: 2610030K20Rik, 1700006C06Rik, Hspc171
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66320
Homologene: 40930
Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
Synonyms: P450-2D, Cyp2d
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545123
VEGA: 15
Homologene: 86099
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Del(8)Bru44H, Del(8)44H, Col4a-1, alpha1(IV) collagen, Raw, Svc, Bru
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73470
Homologene: 23775
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik, D3Bwg1078e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Trim30b
Name: tripartite motif-containing 30B
Synonyms: A530023O14Rik, Trim30-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244183
Tmem144
Name: transmembrane protein 144
Synonyms: 5730537D05Rik, 1110057I03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70652
Homologene: 41250
Htatip2
Name: HIV-1 Tat interactive protein 2
Synonyms: TIP30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53415
Homologene: 4676
Or8d23
Name: olfactory receptor family 8 subfamily D member 23
Synonyms: Olfr930, GA_x6K02T2PVTD-32626123-32627049, MOR171-46
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258269
VEGA: 9
HGNC: HGNC:8481
Homologene: 138304
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Cfh
Name: complement component factor h
Synonyms: Sas1, Mud-1, Sas-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Gabrg3
Name: gamma-aminobutyric acid type A receptor, subunit gamma 3
Synonyms: Gabrg-3, B230362M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14407
HGNC: HGNC:4088
Homologene: 22444
Cenpo
Name: centromere protein O
Synonyms: 8430427C03Rik, 2810429O05Rik, D12Ertd482e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52504
Homologene: 49760
Or1j4
Name: olfactory receptor family 1 subfamily J member 4
Synonyms: GA_x6K02T2NLDC-33544602-33545540, MOR136-13, Olfr350
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258620
HGNC: HGNC:8211
Homologene: 64897
Ccdc115
Name: coiled-coil domain containing 115
Synonyms: 2310061I09Rik, Ccp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69668
Homologene: 13015
Trappc13
Name: trafficking protein particle complex 13
Synonyms: 2610524F24Rik, 2410002O22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66975
Homologene: 11792
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22786
Homologene: 33483
Parp12
Name: poly (ADP-ribose) polymerase family, member 12
Synonyms: Zc3hdc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243771
Homologene: 11236
Ift57
Name: intraflagellar transport 57
Synonyms: MHS4R2, 4833420A15Rik, Esrrbl1, HIPPI
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73916
Homologene: 32383
Ly9
Name: lymphocyte antigen 9
Synonyms: CD229, SLAMF3, T100, Lgp100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Psg25
Name: pregnancy-specific beta-1-glycoprotein 25
Synonyms: cea13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114868
HGNC: HGNC:1819
Homologene: 110989
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: Gpr124, 9530074E10Rik, Tem5, 8430414O08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78560
Homologene: 13112
Hadha
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Synonyms: Mtpa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97212
HGNC: HGNC:4801
Homologene: 152
Tex36
Name: testis expressed 36
Synonyms: 4930404H21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73808
Homologene: 67014
Msantd5f1
Name: Myb/SANT DNA binding domain containing 5 family member 1
Synonyms: Gm428, LOC242502
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242502
Homologene: 128423
Mal2
Name: mal, T cell differentiation protein 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105853
VEGA: 15
Homologene: 14167
Kcnk13
Name: potassium channel, subfamily K, member 13
Synonyms: THIK-1, LOC381712, F730021E22Rik, LOC380778
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217826
HGNC: HGNC:6275
Homologene: 69351
Mettl21e
Name: methyltransferase like 21E
Synonyms: LOC381340, 4832428D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 403183
Homologene: 19006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,813,982 bp
  • C to T, chromosome 1 at 34,439,283 bp
  • C to A, chromosome 1 at 38,406,497 bp
  • T to A, chromosome 1 at 44,206,366 bp
  • T to A, chromosome 1 at 71,613,907 bp
  • T to A, chromosome 1 at 140,102,362 bp
  • T to C, chromosome 1 at 171,601,155 bp
  • A to T, chromosome 2 at 36,850,222 bp
  • T to A, chromosome 3 at 79,832,099 bp
  • C to A, chromosome 3 at 97,767,024 bp
  • C to T, chromosome 3 at 138,186,188 bp
  • A to G, chromosome 4 at 52,855,695 bp
  • A to G, chromosome 4 at 73,687,384 bp
  • C to A, chromosome 4 at 83,012,014 bp
  • T to C, chromosome 5 at 8,989,641 bp
  • A to C, chromosome 5 at 25,310,517 bp
  • C to A, chromosome 5 at 30,147,979 bp
  • A to G, chromosome 5 at 32,827,759 bp
  • T to G, chromosome 5 at 34,288,105 bp
  • T to G, chromosome 5 at 129,903,185 bp
  • T to C, chromosome 6 at 39,111,736 bp
  • A to T, chromosome 6 at 50,227,398 bp
  • C to T, chromosome 7 at 18,521,398 bp
  • T to A, chromosome 7 at 49,770,918 bp
  • T to C, chromosome 7 at 56,773,311 bp
  • CG to CGACGGCGGTG, chromosome 7 at 97,579,908 bp
  • T to A, chromosome 7 at 104,363,753 bp
  • T to C, chromosome 7 at 123,321,901 bp
  • A to G, chromosome 7 at 133,587,273 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • A to G, chromosome 8 at 11,202,926 bp
  • C to A, chromosome 8 at 27,113,436 bp
  • T to A, chromosome 8 at 27,113,437 bp
  • G to A, chromosome 8 at 84,673,215 bp
  • G to A, chromosome 8 at 105,328,230 bp
  • T to C, chromosome 9 at 27,030,809 bp
  • T to A, chromosome 9 at 38,930,476 bp
  • T to C, chromosome 10 at 14,130,583 bp
  • G to T, chromosome 10 at 50,849,646 bp
  • T to A, chromosome 10 at 83,558,893 bp
  • T to A, chromosome 10 at 107,686,225 bp
  • A to T, chromosome 10 at 118,205,810 bp
  • G to A, chromosome 11 at 46,407,591 bp
  • C to A, chromosome 11 at 54,055,848 bp
  • G to T, chromosome 11 at 58,995,453 bp
  • A to T, chromosome 11 at 82,719,959 bp
  • G to A, chromosome 11 at 91,575,915 bp
  • A to T, chromosome 11 at 104,721,458 bp
  • A to G, chromosome 11 at 117,816,494 bp
  • A to T, chromosome 12 at 4,216,539 bp
  • G to T, chromosome 12 at 100,061,689 bp
  • T to C, chromosome 13 at 104,150,152 bp
  • T to C, chromosome 14 at 36,940,081 bp
  • A to G, chromosome 15 at 50,831,605 bp
  • T to C, chromosome 15 at 54,588,357 bp
  • A to T, chromosome 15 at 82,390,138 bp
  • A to T, chromosome 16 at 49,763,804 bp
  • C to A, chromosome 17 at 56,099,211 bp
  • T to A, chromosome 18 at 58,124,321 bp
  • T to C, chromosome 19 at 4,150,771 bp
  • C to T, chromosome 19 at 10,916,513 bp
  • T to A, chromosome 19 at 45,582,748 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045026-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.