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Strain Name:
C57BL/6J-MtgxR6919Btlr/Mmmh
Stock Number:
045039-MU
Citation ID:
RRID:MMRRC_045039-MU
Other Names:
R6919 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Dap3
Name: death associated protein 3
Synonyms: 4921514D13Rik, DAP-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 65111
HGNC: HGNC:2673
Homologene: 3404
Map7
Name: microtubule-associated protein 7
Synonyms: E-MAP-115, mste, ste, mshi, Mtap7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Zfp207
Name: zinc finger protein 207
Synonyms: Zep, 8430401D15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22680
Homologene: 134624
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 26,682,934 bp
  • T to A, chromosome 1 at 75,387,908 bp
  • T to C, chromosome 1 at 86,305,694 bp
  • G to A, chromosome 1 at 181,585,066 bp
  • T to G, chromosome 2 at 23,517,861 bp
  • A to T, chromosome 2 at 32,631,122 bp
  • G to A, chromosome 2 at 84,983,256 bp
  • G to A, chromosome 2 at 88,683,684 bp
  • A to C, chromosome 2 at 113,839,709 bp
  • A to T, chromosome 2 at 160,908,098 bp
  • A to G, chromosome 2 at 168,230,275 bp
  • T to C, chromosome 3 at 13,777,031 bp
  • A to G, chromosome 3 at 88,930,989 bp
  • G to T, chromosome 4 at 3,569,669 bp
  • A to G, chromosome 4 at 85,115,368 bp
  • T to A, chromosome 4 at 148,500,031 bp
  • A to G, chromosome 5 at 30,622,400 bp
  • T to A, chromosome 5 at 30,904,717 bp
  • T to A, chromosome 5 at 43,703,215 bp
  • A to T, chromosome 5 at 64,097,025 bp
  • G to A, chromosome 5 at 121,384,074 bp
  • G to A, chromosome 5 at 124,712,161 bp
  • A to G, chromosome 5 at 125,506,163 bp
  • T to C, chromosome 5 at 136,744,234 bp
  • T to G, chromosome 6 at 3,376,313 bp
  • C to T, chromosome 6 at 66,731,720 bp
  • C to T, chromosome 6 at 82,557,073 bp
  • C to A, chromosome 7 at 4,143,626 bp
  • C to T, chromosome 7 at 25,271,777 bp
  • A to G, chromosome 7 at 104,129,008 bp
  • T to A, chromosome 8 at 95,248,375 bp
  • T to A, chromosome 8 at 108,800,528 bp
  • T to C, chromosome 8 at 120,145,482 bp
  • T to A, chromosome 8 at 122,490,281 bp
  • C to T, chromosome 9 at 18,660,299 bp
  • G to A, chromosome 9 at 22,812,544 bp
  • A to G, chromosome 9 at 39,047,531 bp
  • A to G, chromosome 9 at 67,927,452 bp
  • T to C, chromosome 9 at 118,887,815 bp
  • A to T, chromosome 10 at 12,693,470 bp
  • A to G, chromosome 10 at 20,171,082 bp
  • G to T, chromosome 10 at 50,645,753 bp
  • A to T, chromosome 10 at 62,957,003 bp
  • A to G, chromosome 10 at 76,385,798 bp
  • A to G, chromosome 10 at 103,025,200 bp
  • A to G, chromosome 10 at 127,741,842 bp
  • A to G, chromosome 11 at 5,629,299 bp
  • A to G, chromosome 11 at 54,341,756 bp
  • A to G, chromosome 11 at 55,282,771 bp
  • T to A, chromosome 11 at 60,749,493 bp
  • T to A, chromosome 11 at 62,840,869 bp
  • A to G, chromosome 11 at 65,152,530 bp
  • C to T, chromosome 11 at 80,395,503 bp
  • G to A, chromosome 11 at 86,495,330 bp
  • A to G, chromosome 12 at 59,129,895 bp
  • T to A, chromosome 12 at 72,506,393 bp
  • T to C, chromosome 12 at 112,774,684 bp
  • A to T, chromosome 13 at 38,167,655 bp
  • A to G, chromosome 13 at 42,183,452 bp
  • A to G, chromosome 13 at 54,796,033 bp
  • C to T, chromosome 13 at 58,573,443 bp
  • A to G, chromosome 13 at 74,671,433 bp
  • C to T, chromosome 14 at 25,643,638 bp
  • T to A, chromosome 14 at 27,449,801 bp
  • C to G, chromosome 14 at 30,004,271 bp
  • T to C, chromosome 14 at 64,097,488 bp
  • T to A, chromosome 14 at 75,456,138 bp
  • T to C, chromosome 14 at 96,136,594 bp
  • T to A, chromosome 14 at 118,594,894 bp
  • A to T, chromosome 14 at 121,643,152 bp
  • T to C, chromosome 15 at 82,081,930 bp
  • A to T, chromosome 16 at 17,899,701 bp
  • T to C, chromosome 16 at 73,961,867 bp
  • A to T, chromosome 17 at 8,130,282 bp
  • A to T, chromosome 17 at 34,183,225 bp
  • C to G, chromosome 17 at 35,127,246 bp
  • A to T, chromosome 17 at 35,987,533 bp
  • A to T, chromosome 17 at 58,293,953 bp
  • A to G, chromosome 17 at 81,388,872 bp
  • A to T, chromosome 18 at 58,124,187 bp
  • A to G, chromosome 18 at 77,011,038 bp
  • A to G, chromosome 19 at 6,080,737 bp
  • C to A, chromosome 19 at 11,171,885 bp
  • G to A, chromosome 19 at 39,291,141 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6919 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045039-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.