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Strain Name:
C57BL/6J-MtgxR6939Btlr/Mmmh
Stock Number:
045053-MU
Citation ID:
RRID:MMRRC_045053-MU
Other Names:
R6939 (G1)
Major Collection:

Strain Information

Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Fus
Name: fused in sarcoma
Synonyms: translocated in liposarcoma, Tls, hnRNP P2, pigpen, D930039C12Rik, D430004D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Zfp866
Name: zinc finger protein 866
Synonyms: 9830167H18Rik, D330038O06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330788
Cntnap1
Name: contactin associated protein-like 1
Synonyms: p190, Caspr, Nrxn4, NCP1, paranodin, shm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53321
HGNC: HGNC:8011
Homologene: 2693
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,194,349 bp
  • C to A, chromosome 2 at 26,407,762 bp
  • T to C, chromosome 2 at 90,459,514 bp
  • A to T, chromosome 2 at 120,307,301 bp
  • A to G, chromosome 3 at 32,198,316 bp
  • C to A, chromosome 3 at 87,686,920 bp
  • T to A, chromosome 3 at 88,686,517 bp
  • C to A, chromosome 4 at 134,767,974 bp
  • T to C, chromosome 4 at 143,948,796 bp
  • G to A, chromosome 5 at 31,257,586 bp
  • A to T, chromosome 5 at 45,453,754 bp
  • T to C, chromosome 5 at 52,376,265 bp
  • T to A, chromosome 5 at 117,765,561 bp
  • T to C, chromosome 5 at 143,727,969 bp
  • C to A, chromosome 6 at 17,281,411 bp
  • A to T, chromosome 6 at 83,059,465 bp
  • G to A, chromosome 6 at 124,512,801 bp
  • C to A, chromosome 6 at 125,106,538 bp
  • A to G, chromosome 6 at 145,175,219 bp
  • T to C, chromosome 7 at 16,115,257 bp
  • C to T, chromosome 7 at 16,811,826 bp
  • T to A, chromosome 7 at 19,088,224 bp
  • T to A, chromosome 7 at 27,879,048 bp
  • T to A, chromosome 7 at 29,052,326 bp
  • C to T, chromosome 7 at 35,485,599 bp
  • T to C, chromosome 7 at 46,907,099 bp
  • A to G, chromosome 7 at 64,268,297 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • G to A, chromosome 7 at 96,553,496 bp
  • C to A, chromosome 7 at 108,055,105 bp
  • T to C, chromosome 7 at 119,778,455 bp
  • A to T, chromosome 7 at 127,972,569 bp
  • T to C, chromosome 7 at 134,364,479 bp
  • G to T, chromosome 8 at 69,766,221 bp
  • A to G, chromosome 8 at 80,615,145 bp
  • A to T, chromosome 8 at 80,705,320 bp
  • C to A, chromosome 8 at 111,942,569 bp
  • T to A, chromosome 9 at 18,638,537 bp
  • T to C, chromosome 9 at 39,686,891 bp
  • T to C, chromosome 9 at 42,347,997 bp
  • T to A, chromosome 10 at 22,174,357 bp
  • T to A, chromosome 11 at 30,837,291 bp
  • C to T, chromosome 11 at 55,252,474 bp
  • A to G, chromosome 11 at 69,406,762 bp
  • G to A, chromosome 11 at 69,658,055 bp
  • A to C, chromosome 11 at 101,186,511 bp
  • A to C, chromosome 11 at 102,800,907 bp
  • A to G, chromosome 11 at 115,785,830 bp
  • A to T, chromosome 11 at 121,222,338 bp
  • G to T, chromosome 12 at 28,541,497 bp
  • A to T, chromosome 12 at 118,106,562 bp
  • A to G, chromosome 13 at 58,409,355 bp
  • T to A, chromosome 13 at 59,742,058 bp
  • C to T, chromosome 14 at 34,003,600 bp
  • A to G, chromosome 14 at 65,066,740 bp
  • T to C, chromosome 14 at 70,775,605 bp
  • G to A, chromosome 15 at 60,920,395 bp
  • T to C, chromosome 16 at 32,663,878 bp
  • A to G, chromosome 16 at 36,839,912 bp
  • A to T, chromosome 16 at 58,926,285 bp
  • A to T, chromosome 17 at 12,876,935 bp
  • T to A, chromosome 17 at 14,001,125 bp
  • A to G, chromosome 17 at 56,183,737 bp
  • A to G, chromosome 18 at 60,958,154 bp
  • A to T, chromosome 19 at 3,276,907 bp
  • A to G, chromosome 19 at 6,838,069 bp
  • T to C, chromosome 19 at 39,643,334 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6939 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045053-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.