Strain Name:
C57BL/6J-MtgxR6939Btlr/Mmmh
Stock Number:
045053-MU
Citation ID:
RRID:MMRRC_045053-MU
Other Names:
R6939 (G1)
Major Collection:

Strain Information

Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Fus
Name: fused in sarcoma
Synonyms: translocated in liposarcoma, Tls, hnRNP P2, pigpen, D930039C12Rik, D430004D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Zfp866
Name: zinc finger protein 866
Synonyms: 9830167H18Rik, D330038O06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330788
Cntnap1
Name: contactin associated protein-like 1
Synonyms: p190, Caspr, Nrxn4, NCP1, paranodin, shm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53321
HGNC: HGNC:8011
Homologene: 2693
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: Byp, DEP-1, Scc-1, Scc1, CD148, RPTPJ
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Tsg101
Name: tumor susceptibility gene 101
Synonyms: CC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22088
Homologene: 4584
Mpdu1
Name: mannose-P-dolichol utilization defect 1
Synonyms: SL15, Supl15h, LEC35
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24070
HGNC: HGNC:7207
Homologene: 3581
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
Synonyms: Catf1, AEP, Smbp2, sma, Smubp2, p110 subunit, RIPE3b1, Smbp-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Extl3
Name: exostosin-like glycosyltransferase 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 3110031A07Rik, 2410140K03Rik, D5Ertd591e, A630018G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216850
Homologene: 18945
Ift172
Name: intraflagellar transport 172
Synonyms: wim, 4930553F24Rik, avc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67661
Homologene: 15202
Gjc1
Name: gap junction protein, gamma 1
Synonyms: connexin 45, Cx45, Gja-7, C130009G16Rik, Gja7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14615
HGNC: HGNC:4280
Homologene: 4016
Iqcb1
Name: IQ calmodulin-binding motif containing 1
Synonyms: 6820449I09Rik, NPHP5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320299
Homologene: 8766
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Gabarapl2
Name: GABA type A receptor associated protein like 2
Synonyms: Gef2, 0610012F20Rik, GATE-16, 2900019O08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93739
Homologene: 68550
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333050
Homologene: 45469
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1203Clo, b2b1279Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
A1bg
Name: alpha-1-B glycoprotein
Synonyms: C44
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 117586
VEGA: 15
HGNC: HGNC:5
Homologene: 11167
Dnai7
Name: dynein axonemal intermediate chain 7
Synonyms: A230084G12Rik, Las1, Casc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320662
Homologene: 41242
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, 4732499L03Rik, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Zfp607a
Name: zinc finger protein 607A
Synonyms: 4732475C15Rik, Zfp607
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545938
Homologene: 134321
Tdrd12
Name: tudor domain containing 12
Synonyms: 2410070K17Rik, G1-476-14, ecat8, 2410004F06Rik, EG434165, repro23
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71981
Homologene: 87053
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Ldlrap1
Name: low density lipoprotein receptor adaptor protein 1
Synonyms: Arh1, Arh
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100017
Homologene: 9219
Hexd
Name: hexosaminidase D
Synonyms: Hexdc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238023
Homologene: 68120
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64436
Homologene: 56863
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: LOC242997, Gm447
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503884
Homologene: 65264
Smarca5
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Synonyms: Snf2h, D330027N15Rik, 4933427E24Rik, D030040M08Rik, MommeD4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93762
Homologene: 55764
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: P21cdc42Hs kinase, Ack, activated p21cdc42Hs kinase, ACK1, Pyk1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 51789
Homologene: 4224
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Mrgprh
Name: MAS-related GPR, member H
Synonyms: MrgH, Gpr90
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80978
VEGA: 17
Homologene: 12758
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik, Fats
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71007
Homologene: 18998
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93838
Homologene: 14143
Or10ab4
Name: olfactory receptor family 10 subfamily AB member 4
Synonyms: GA_x6K02T2PBJ9-10384085-10385068, MOR267-15, Olfr479
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257891
Homologene: 79346
Acsm3
Name: acyl-CoA synthetase medium-chain family member 3
Synonyms: Sa, Sah
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20216
Homologene: 74559
Rftn2
Name: raftlin family member 2
Synonyms: 2700010E02Rik, 3222401M22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74013
Homologene: 16954
Rps6ka4
Name: ribosomal protein S6 kinase, polypeptide 4
Synonyms: MSK2, 1110069D02Rik, 90kDa
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56613
VEGA: 19
Homologene: 69288
Or5k17
Name: olfactory receptor family 5 subfamily K member 17
Synonyms: GA_x54KRFPKG5P-55145984-55145034, MOR184-4, Olfr181
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259001
Homologene: 74112
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545288
Homologene: 74936
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: 4732472I07Rik, Pla2zeta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271844
Homologene: 77933
Napa
Name: N-ethylmaleimide sensitive fusion protein attachment protein alpha
Synonyms: SNARE, a-SNAP, RA81, SNAPA, 1500039N14Rik, hyh
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108124
HGNC: HGNC:7641
Homologene: 2839
Spata31d1e
Name: spermatogenesis associated 31 subfamily D, member 1E
Synonyms: 1700014D04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102638268
Homologene: 140986
Fkrp
Name: fukutin related protein
Synonyms: LGMD1I, MDC1C, A830029B19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243853
Homologene: 11513
Dcdc2c
Name: doublecortin domain containing 2C
Synonyms: 1110015M06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68511
Homologene: 131934
Clrn2
Name: clarin 2
Synonyms: EG624224, mpc169H
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 624224
Homologene: 84057
Dok2
Name: docking protein 2
Synonyms: DokR, Frip, Frip
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13449
HGNC: HGNC:2991
Homologene: 2957
Cav2
Name: caveolin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12390
HGNC: HGNC:1528
Homologene: 942
Kcnmb2
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 2
Synonyms: 3110031N04Rik, 2700049B16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72413
HGNC: HGNC:6286
Homologene: 4257
Rmi1
Name: RecQ mediated genome instability 1
Synonyms: 4932432N11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74386
VEGA: 13
Homologene: 41601
Raet1e
Name: retinoic acid early transcript 1E
Synonyms: Rae-1 epsilon
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 379043
Homologene: 134115
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 664821
Homologene: 133217
Mydgf
Name: myeloid derived growth factor
Synonyms: D17Wsu104e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 28106
Homologene: 10425
Or10n7-ps1
Name: olfactory receptor family 10 subfamily N member 7, pseudogene 1
Synonyms: GA_x6K02T2PVTD-33383715-33382802, MOR224-1, Olfr964-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258855
VEGA: 9
Gm30083
Name: predicted gene, 30083
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102631856
VEGA: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,194,349 bp
  • C to A, chromosome 2 at 26,407,762 bp
  • T to C, chromosome 2 at 90,459,514 bp
  • A to T, chromosome 2 at 120,307,301 bp
  • A to G, chromosome 3 at 32,198,316 bp
  • C to A, chromosome 3 at 87,686,920 bp
  • T to A, chromosome 3 at 88,686,517 bp
  • C to A, chromosome 4 at 134,767,974 bp
  • T to C, chromosome 4 at 143,948,796 bp
  • G to A, chromosome 5 at 31,257,586 bp
  • A to T, chromosome 5 at 45,453,754 bp
  • T to C, chromosome 5 at 52,376,265 bp
  • T to A, chromosome 5 at 117,765,561 bp
  • T to C, chromosome 5 at 143,727,969 bp
  • C to A, chromosome 6 at 17,281,411 bp
  • A to T, chromosome 6 at 83,059,465 bp
  • G to A, chromosome 6 at 124,512,801 bp
  • C to A, chromosome 6 at 125,106,538 bp
  • A to G, chromosome 6 at 145,175,219 bp
  • T to C, chromosome 7 at 16,115,257 bp
  • C to T, chromosome 7 at 16,811,826 bp
  • T to A, chromosome 7 at 19,088,224 bp
  • T to A, chromosome 7 at 27,879,048 bp
  • T to A, chromosome 7 at 29,052,326 bp
  • C to T, chromosome 7 at 35,485,599 bp
  • T to C, chromosome 7 at 46,907,099 bp
  • A to G, chromosome 7 at 64,268,297 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • G to A, chromosome 7 at 96,553,496 bp
  • C to A, chromosome 7 at 108,055,105 bp
  • T to C, chromosome 7 at 119,778,455 bp
  • A to T, chromosome 7 at 127,972,569 bp
  • T to C, chromosome 7 at 134,364,479 bp
  • G to T, chromosome 8 at 69,766,221 bp
  • A to G, chromosome 8 at 80,615,145 bp
  • A to T, chromosome 8 at 80,705,320 bp
  • C to A, chromosome 8 at 111,942,569 bp
  • T to A, chromosome 9 at 18,638,537 bp
  • T to C, chromosome 9 at 39,686,891 bp
  • T to C, chromosome 9 at 42,347,997 bp
  • T to A, chromosome 10 at 22,174,357 bp
  • T to A, chromosome 11 at 30,837,291 bp
  • C to T, chromosome 11 at 55,252,474 bp
  • A to G, chromosome 11 at 69,406,762 bp
  • G to A, chromosome 11 at 69,658,055 bp
  • A to C, chromosome 11 at 101,186,511 bp
  • A to C, chromosome 11 at 102,800,907 bp
  • A to G, chromosome 11 at 115,785,830 bp
  • A to T, chromosome 11 at 121,222,338 bp
  • G to T, chromosome 12 at 28,541,497 bp
  • A to T, chromosome 12 at 118,106,562 bp
  • A to G, chromosome 13 at 58,409,355 bp
  • T to A, chromosome 13 at 59,742,058 bp
  • C to T, chromosome 14 at 34,003,600 bp
  • A to G, chromosome 14 at 65,066,740 bp
  • T to C, chromosome 14 at 70,775,605 bp
  • G to A, chromosome 15 at 60,920,395 bp
  • T to C, chromosome 16 at 32,663,878 bp
  • A to G, chromosome 16 at 36,839,912 bp
  • A to T, chromosome 16 at 58,926,285 bp
  • A to T, chromosome 17 at 12,876,935 bp
  • T to A, chromosome 17 at 14,001,125 bp
  • A to G, chromosome 17 at 56,183,737 bp
  • A to G, chromosome 18 at 60,958,154 bp
  • A to T, chromosome 19 at 3,276,907 bp
  • A to G, chromosome 19 at 6,838,069 bp
  • T to C, chromosome 19 at 39,643,334 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6939 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045053-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.