Strain Name:
C57BL/6J-MtgxR6947Btlr/Mmmh
Stock Number:
045060-MU
Citation ID:
RRID:MMRRC_045060-MU
Other Names:
R6947 (G1)
Major Collection:

Strain Information

Trp53
Name: transformation related protein 53
Synonyms: p44, p53
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22059
Homologene: 460
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: 1200015E08Rik, D13Ertd524e, Lgals-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: Mll5, D230038D11Rik, 1810033J14Rik, 9530077A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase
Synonyms: Mhdaali18, Ali18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14191
HGNC: HGNC:3697
Homologene: 3842
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, T-associated sex reversal, Mekk4, MAPKKK4, RP17, D17Rp17, D17Rp17e, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: 6330590F17Rik, D5Ertd483e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100756
Homologene: 32789
Cep290
Name: centrosomal protein 290
Synonyms: b2b1752Clo, Nphp6, Kiaa, b2b1454Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Cnot8
Name: CCR4-NOT transcription complex, subunit 8
Synonyms: 1810022F04Rik, 1500015I04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69125
HGNC: HGNC:9207
Homologene: 48304
Bop1
Name: block of proliferation 1
Synonyms: Erb1p
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12181
VEGA: 15
Homologene: 6612
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Mettl25
Name: methyltransferase like 25
Synonyms: BC067068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216292
Homologene: 32774
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: MmRad24, 9430035O09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Eif2d
Name: eukaryotic translation initiation factor 2D
Synonyms: Lgtn, D1Ertd5e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16865
HGNC: HGNC:6583
Homologene: 38244
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, C130039F11Rik, A330049M09Rik, enaptin165, nesprin-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Cxxc4
Name: CXXC finger 4
Synonyms: Idax, C030003J12Rik, 9330210J02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319478
Homologene: 11878
Lypd8
Name: LY6/PLAUR domain containing 8
Synonyms: 2210415F13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70163
Homologene: 52815
Naxd
Name: NAD(P)HX dehydratase
Synonyms: 2810407E01Rik, 0710008K08Rik, Carkd
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69225
Homologene: 6333
Rad54b
Name: RAD54 homolog B (S. cerevisiae)
Synonyms: E130016E03Rik, E130016E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 623474
Homologene: 8240
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70129
Homologene: 11359
Ruvbl2
Name: RuvB-like AAA ATPase 2
Synonyms: p47, mp47
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20174
Homologene: 4856
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Slc16a12
Name: solute carrier family 16 (monocarboxylic acid transporters), member 12
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240638
Homologene: 130007
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18795
Homologene: 22876
Adamts7
Name: ADAM metallopeptidase with thrombospondin type 1 motif 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Rhobtb3
Name: Rho-related BTB domain containing 3
Synonyms: 2610033K01Rik, 1700040C17Rik, 4930503C18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73296
Homologene: 8932
Or5m10b
Name: olfactory receptor family 5 subfamily M member 10B
Synonyms: MOR196-1, Olfr1022, GA_x6K02T2Q125-47347069-47348016
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258582
Homologene: 128086
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd377e, D8Ertd370e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57247
Homologene: 10731
Thbs2
Name: thrombospondin 2
Synonyms: TSP2, Thrombospondin-2, Thbs-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626596
Homologene: 75047
Rbm20
Name: RNA binding motif protein 20
Synonyms: 1110018J23Rik, 2010003H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73713
Homologene: 28386
Tmem171
Name: transmembrane protein 171
Synonyms: LOC380863
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380863
Homologene: 18301
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Kng1
Name: kininogen 1
Synonyms: H-kininigen, L-kininogen
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Mos
Name: Moloney sarcoma oncogene
Synonyms: c-mos
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17451
HGNC: HGNC:7199
Homologene: 3919
Idnk
Name: idnK gluconokinase homolog (E. coli)
Synonyms: 5133401N09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75731
VEGA: 13
Homologene: 5666
Sowaha
Name: sosondowah ankyrin repeat domain family member A
Synonyms: Ankrd43, A830006N08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237761
Homologene: 18488
Lrit3
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms: LOC242235
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242235
Homologene: 19426
Or1p4-ps1
Name: olfactory receptor family 1 subfamily P member 4, pseudogene 1
Synonyms: MOR133-2, Olfr409-ps1, GA_x6K02T2P1NL-4449217-4450187
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 131,164,667 bp
  • T to A, chromosome 2 at 76,894,388 bp
  • T to C, chromosome 2 at 85,868,927 bp
  • A to G, chromosome 2 at 135,386,155 bp
  • T to A, chromosome 3 at 129,789,234 bp
  • C to T, chromosome 3 at 134,240,516 bp
  • A to C, chromosome 4 at 3,871,585 bp
  • T to G, chromosome 4 at 11,569,859 bp
  • T to A, chromosome 4 at 132,995,069 bp
  • T to C, chromosome 5 at 23,497,545 bp
  • T to C, chromosome 5 at 108,161,535 bp
  • T to C, chromosome 5 at 114,103,760 bp
  • A to G, chromosome 7 at 45,424,949 bp
  • T to C, chromosome 8 at 11,502,757 bp
  • C to A, chromosome 8 at 123,254,904 bp
  • C to T, chromosome 8 at 125,850,282 bp
  • C to A, chromosome 9 at 90,191,804 bp
  • A to G, chromosome 10 at 5,175,789 bp
  • A to G, chromosome 10 at 76,515,666 bp
  • A to G, chromosome 10 at 100,530,056 bp
  • A to G, chromosome 10 at 105,826,192 bp
  • A to G, chromosome 10 at 117,757,274 bp
  • A to T, chromosome 10 at 128,733,015 bp
  • A to G, chromosome 11 at 53,478,398 bp
  • G to T, chromosome 11 at 58,117,505 bp
  • A to T, chromosome 11 at 58,382,766 bp
  • A to G, chromosome 11 at 69,588,481 bp
  • C to T, chromosome 11 at 74,317,544 bp
  • G to A, chromosome 13 at 12,454,801 bp
  • A to G, chromosome 13 at 58,160,241 bp
  • A to G, chromosome 13 at 75,910,666 bp
  • A to G, chromosome 13 at 98,688,442 bp
  • A to T, chromosome 13 at 100,622,875 bp
  • T to C, chromosome 14 at 55,778,391 bp
  • T to C, chromosome 15 at 36,103,890 bp
  • A to G, chromosome 15 at 76,453,988 bp
  • A to T, chromosome 15 at 82,559,047 bp
  • A to G, chromosome 16 at 23,077,374 bp
  • C to T, chromosome 16 at 32,775,803 bp
  • T to A, chromosome 17 at 8,969,592 bp
  • G to A, chromosome 17 at 12,260,569 bp
  • A to T, chromosome 17 at 14,689,767 bp
  • A to T, chromosome 17 at 34,928,068 bp
  • A to G, chromosome 19 at 8,064,510 bp
  • A to G, chromosome 19 at 34,672,607 bp
  • G to A, chromosome 19 at 53,851,265 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6947 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045060-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.