Strain Name:
C57BL/6J-MtgxR6952Btlr/Mmmh
Stock Number:
045064-MU
Citation ID:
RRID:MMRRC_045064-MU
Other Names:
R6952 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Whi, GENA 60, GENA 47, Gena 52, Cyn, Cycn, Dz, WBE1, Edy, Flo, Lda, Mt, Obt, Todo, A730019I05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, beta-MHC, MyHC-I, B-MHC, Myhcb, Myhc-b, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: Tarpp, ARPP-21, 0710001E13Rik, R3hdm3, D9Bwg1012e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: Jmjd2c, 2410141F18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76804
Homologene: 41004
Dusp1
Name: dual specificity phosphatase 1
Synonyms: MKP1, erp, mkp-1, Ptpn16, 3CH134
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19252
HGNC: HGNC:3064
Homologene: 3254
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: 90kDa, Rsk3, p90rsk, Rps6ka-rs1, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Synonyms: Agat, AGT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17314
HGNC: HGNC:7059
Homologene: 31089
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Mccc2
Name: methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
Synonyms: 4930552N12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78038
VEGA: 13
HGNC: HGNC:6937
Homologene: 11145
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Limk1
Name: LIM domain kinase 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16885
HGNC: HGNC:6613
Homologene: 1738
Ik
Name: IK cytokine
Synonyms: MuRED
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24010
VEGA: 18
HGNC: HGNC:5958
Homologene: 36193
Atp6v1b1
Name: ATPase, H+ transporting, lysosomal V1 subunit B1
Synonyms: D630030L16Rik, D630039P21Rik, lysosomal 56/58kDa, Atp6b1, Vpp3, Vpp-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110935
HGNC: HGNC:853
Homologene: 68198
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: 0610033B08Rik, VRL-2, VROAC, OTRPC4, Trp12, VR-OAC
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 63873
Homologene: 11003
Gpr183
Name: G protein-coupled receptor 183
Synonyms: Ebi2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 321019
VEGA: 14
HGNC: HGNC:3128
Homologene: 28066
Abcf3
Name: ATP-binding cassette, sub-family F member 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27406
HGNC: HGNC:72
Homologene: 22784
Brd3
Name: bromodomain containing 3
Synonyms: Fsrg2, RINGL3, ORFX, 2410084F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67382
HGNC: HGNC:1104
Homologene: 81801
Tvp23b
Name: trans-golgi network vesicle protein 23B
Synonyms: 1810036I24Rik, Fam18b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67510
Homologene: 128511
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
Gga2
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2
Synonyms: 1200007E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74105
Homologene: 22860
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Mep1b
Name: meprin 1 beta
Synonyms: meprin beta, Mep-1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Vmn1r37
Name: vomeronasal 1 receptor 37
Synonyms: V1rc10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171183
Homologene: 110800
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Or4a80
Name: olfactory receptor family 4 subfamily A member 80
Synonyms: Olfr1253-ps1, Olfr1559-ps1, GA_x6K02T2Q125-51193814-51192857, MOR231-19P, Olfr1253, MOR231-19P, MOR231-18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258370
Haspin
Name: histone H3 associated protein kinase
Synonyms: Gsg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14841
Homologene: 49236
Ccdc148
Name: coiled-coil domain containing 148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227933
Homologene: 16353
Mdm1
Name: MDM1 nuclear protein
Synonyms: Mdm-1, transformed mouse 3T3 cell double minute 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17245
VEGA: 10
Homologene: 9692
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69922
Homologene: 55966
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216859
Homologene: 22835
Plekhh3
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217198
Homologene: 11787
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, TRIM20, FMF, pyrin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: Fam189a2, LOC381217
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Cimap2
Name: ciliary microtubule associated protein 2
Synonyms: BC055111, Lexm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242602
Homologene: 17630
Dapk2
Name: death-associated protein kinase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13143
HGNC: HGNC:2675
Homologene: 74940
Slc47a1
Name: solute carrier family 47, member 1
Synonyms: MATE1, 1300013J15Rik, mMATE1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67473
Homologene: 34364
Chit1
Name: chitinase 1
Synonyms: 2300002L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Mrgpra6
Name: MAS-related GPR, member A6
Synonyms: MrgA6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381886
Taco1
Name: translational activator of mitochondrially encoded cytochrome c oxidase I
Synonyms: Ccdc44, 2310066I18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70207
Homologene: 39079
Zfp383
Name: zinc finger protein 383
Synonyms: 1110003H10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73729
Homologene: 128413
Cga
Name: glycoprotein hormones, alpha subunit
Synonyms: Tsha, aGSU, alpha-GSU, alphaSU, GPHalpha, alphaGSU
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12640
HGNC: HGNC:1885
Homologene: 587
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 51,762,509 bp
  • T to C, chromosome 1 at 106,172,479 bp
  • T to C, chromosome 1 at 134,143,284 bp
  • T to C, chromosome 2 at 27,454,359 bp
  • T to C, chromosome 2 at 58,823,645 bp
  • A to T, chromosome 2 at 89,752,627 bp
  • A to T, chromosome 4 at 8,856,797 bp
  • A to T, chromosome 4 at 34,905,171 bp
  • T to G, chromosome 4 at 74,357,350 bp
  • C to G, chromosome 4 at 106,610,399 bp
  • G to A, chromosome 5 at 114,633,202 bp
  • T to A, chromosome 5 at 134,670,478 bp
  • A to T, chromosome 6 at 66,731,539 bp
  • T to C, chromosome 6 at 83,754,810 bp
  • T to C, chromosome 7 at 29,914,955 bp
  • A to T, chromosome 7 at 47,185,945 bp
  • T to G, chromosome 7 at 105,713,688 bp
  • A to T, chromosome 7 at 113,351,943 bp
  • C to A, chromosome 7 at 121,998,888 bp
  • T to C, chromosome 7 at 136,951,335 bp
  • C to G, chromosome 9 at 66,254,622 bp
  • G to A, chromosome 9 at 112,126,482 bp
  • A to G, chromosome 10 at 118,168,057 bp
  • T to A, chromosome 11 at 26,535,597 bp
  • T to A, chromosome 11 at 61,344,454 bp
  • T to A, chromosome 11 at 62,885,126 bp
  • C to A, chromosome 11 at 69,885,517 bp
  • T to C, chromosome 11 at 73,136,145 bp
  • T to C, chromosome 11 at 101,165,656 bp
  • T to C, chromosome 11 at 102,204,960 bp
  • T to C, chromosome 11 at 106,073,116 bp
  • A to T, chromosome 12 at 75,927,431 bp
  • T to C, chromosome 13 at 99,967,726 bp
  • C to T, chromosome 14 at 32,959,966 bp
  • C to T, chromosome 14 at 54,991,740 bp
  • T to C, chromosome 14 at 110,750,542 bp
  • A to G, chromosome 14 at 121,954,485 bp
  • T to G, chromosome 16 at 3,710,880 bp
  • T to G, chromosome 16 at 20,549,734 bp
  • C to A, chromosome 17 at 7,227,978 bp
  • T to C, chromosome 17 at 26,507,603 bp
  • A to T, chromosome 18 at 20,525,159 bp
  • G to A, chromosome 18 at 21,088,670 bp
  • C to T, chromosome 18 at 36,753,560 bp
  • A to T, chromosome 19 at 23,984,718 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6952 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045064-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.