Strain Name:
C57BL/6J-MtgxR6968Btlr/Mmmh
Stock Number:
045078-MU
Citation ID:
RRID:MMRRC_045078-MU
Other Names:
R6968 (G1)
Major Collection:

Strain Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: Acra6, alpha6 nAChR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Snap25
Name: synaptosomal-associated protein 25
Synonyms: GENA 70, Bdr, SNAP-25, sp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20614
Homologene: 13311
Sstr2
Name: somatostatin receptor 2
Synonyms: Smstr-2, Smstr2, SSTR-2, sst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20606
Homologene: 37427
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Sema3f
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms: Sema IV, Semak
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20350
Homologene: 20885
Asah2
Name: N-acylsphingosine amidohydrolase 2
Synonyms: neutral/alkaline ceramidase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54447
VEGA: 19
Homologene: 10310
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: Tnrc6, CAGH26, D130023A07Rik, 3110054G10Rik, 2010321I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Stam
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Synonyms: STAM1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20844
Homologene: 37788
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: P200, ARFGEP1, D130059B05Rik, BIG1, D730028O18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Foxk2
Name: forkhead box K2
Synonyms: 1110054H05Rik, Ilf1, 5730434B08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68837
HGNC: HGNC:6036
Homologene: 18748
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, enaptin165, SYNE-1, C130039F11Rik, A330049M09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Nsun2
Name: NOL1/NOP2/Sun domain family member 2
Synonyms: Misu
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28114
Homologene: 9817
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, per, Pcn, Plc
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Tln1
Name: talin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21894
Homologene: 21267
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Odz3, 2610100B16Rik, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Golm1
Name: golgi membrane protein 1
Synonyms: Golph2, 2310001L02Rik, GP73, PSEC0257, D030064E01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Cmip
Name: c-Maf inducing protein
Synonyms: 5830471E12Rik, 4933407C03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74440
Homologene: 18869
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242747
Homologene: 138474
Apip
Name: APAF1 interacting protein
Synonyms: CGI-29, Mmrp19, APIP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56369
Homologene: 6277
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: eip1 (E47 interaction protein 1), Sharp2, DEC1, Bhlhb2, Clast5, CR8, cytokine response gene 8, Stra13, Stra14, C130042M06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: Nurr1, HZF-3, RNR-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: NTPDase-3, HB6, Cd39l3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Ormdl3
Name: ORM1-like 3 (S. cerevisiae)
Synonyms: 2810011N17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66612
Homologene: 57032
Rhoh
Name: ras homolog family member H
Synonyms: Arhh, 5830400A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74734
HGNC: HGNC:686
Homologene: 3180
Mmp9
Name: matrix metallopeptidase 9
Synonyms: Gel B, MMP-9, gelatinase B, Gelatinase B, B/MMP9, Clg4b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Cpne2
Name: copine II
Synonyms: 3322401K10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234577
HGNC: HGNC:2315
Homologene: 27392
Pcdh10
Name: protocadherin 10
Synonyms: OL-pc, 6430703F07Rik, 6430521D13Rik, Olpc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18526
Homologene: 74967
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 668758
Homologene: 110776
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243874
Homologene: 18530
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54324
Homologene: 66300
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, b2b643Clo, b2b227.1Clo, Armc4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Jag2
Name: jagged 2
Synonyms: D12Ggc2e, Serh
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Bace1
Name: beta-site APP cleaving enzyme 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23821
HGNC: HGNC:933
Homologene: 8014
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: Efcbp1, STIP-1, NECAB1, 1700003H21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69352
Homologene: 11172
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Hinfp
Name: histone H4 transcription factor
Synonyms: DKFZp434F162, Mizf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102423
VEGA: 9
Homologene: 9174
Vmn2r62
Name: vomeronasal 2, receptor 62
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546964
Homologene: 104832
Nrg2
Name: neuregulin 2
Synonyms: NTAK, Don1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100042150
HGNC: HGNC:7998
Homologene: 75024
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
Cdkn2aip
Name: CDKN2A interacting protein
Synonyms: 4921511I16Rik, CARF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70925
Homologene: 9752
Krt23
Name: keratin 23
Synonyms: K23, CK23, Krt1-23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94179
HGNC: HGNC:6438
Homologene: 9172
Vmn1r113
Name: vomeronasal 1 receptor 113
Synonyms: Gm5748
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436135
Homologene: 104166
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Suox
Name: sulfite oxidase
Synonyms: SO
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211389
VEGA: 10
Homologene: 394
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm6976, Gm29096
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Zfp39
Name: zinc finger protein 39
Synonyms: Zfp-39, CTfin33
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22698
Homologene: 69102
Cyp2w1
Name: cytochrome P450, family 2, subfamily w, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545817
Homologene: 69239
Saxo2
Name: stabilizer of axonemal microtubules 2
Synonyms: 1700129I04Rik, Fam154b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330577
Homologene: 25135
Zfp41
Name: zinc finger protein 41
Synonyms: Zfp-41, CTfin92
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22701
Homologene: 65280
Riox1
Name: ribosomal oxygenase 1
Synonyms: 2410016O06Rik, NO66
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71952
VEGA: 12
Homologene: 11366
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: MOR135-24, MOR135-30_i, Olfr391-ps1, GA_x6K02T2P1NL-3951666-3950698, Olfr391-ps, Olfr391
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
Trgv2
Name: T cell receptor gamma variable 2
Synonyms: Vgamma2, Tcrg-V2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21636
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,153,678 bp
  • G to T, chromosome 1 at 10,153,679 bp
  • A to T, chromosome 2 at 14,116,018 bp
  • G to A, chromosome 2 at 26,430,486 bp
  • T to C, chromosome 2 at 57,108,746 bp
  • C to T, chromosome 2 at 103,089,453 bp
  • T to C, chromosome 2 at 136,769,770 bp
  • A to G, chromosome 2 at 164,952,940 bp
  • T to A, chromosome 3 at 45,379,542 bp
  • T to C, chromosome 4 at 14,957,852 bp
  • C to T, chromosome 4 at 43,550,217 bp
  • T to A, chromosome 4 at 137,535,156 bp
  • A to T, chromosome 4 at 147,826,197 bp
  • A to G, chromosome 5 at 65,892,519 bp
  • T to A, chromosome 5 at 137,461,813 bp
  • A to G, chromosome 5 at 139,353,991 bp
  • T to C, chromosome 6 at 43,275,342 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • T to A, chromosome 6 at 125,108,318 bp
  • T to C, chromosome 6 at 141,487,932 bp
  • T to A, chromosome 7 at 20,049,508 bp
  • A to T, chromosome 7 at 20,787,951 bp
  • T to A, chromosome 7 at 42,788,442 bp
  • T to C, chromosome 7 at 82,643,761 bp
  • T to C, chromosome 7 at 123,182,427 bp
  • C to T, chromosome 8 at 27,406,655 bp
  • C to A, chromosome 8 at 47,713,887 bp
  • C to T, chromosome 8 at 48,236,439 bp
  • T to C, chromosome 8 at 81,844,457 bp
  • C to T, chromosome 8 at 94,548,502 bp
  • T to C, chromosome 8 at 117,377,156 bp
  • A to C, chromosome 9 at 44,297,985 bp
  • A to G, chromosome 9 at 45,854,965 bp
  • C to T, chromosome 9 at 107,691,449 bp
  • A to C, chromosome 9 at 109,330,788 bp
  • A to T, chromosome 9 at 120,560,656 bp
  • T to C, chromosome 10 at 5,117,041 bp
  • T to C, chromosome 10 at 41,673,844 bp
  • G to A, chromosome 10 at 79,540,642 bp
  • C to T, chromosome 10 at 128,671,833 bp
  • T to C, chromosome 11 at 58,891,480 bp
  • A to G, chromosome 11 at 73,799,379 bp
  • T to A, chromosome 11 at 98,584,115 bp
  • T to A, chromosome 11 at 99,481,074 bp
  • T to C, chromosome 11 at 113,624,948 bp
  • T to C, chromosome 11 at 121,260,482 bp
  • C to T, chromosome 12 at 83,951,373 bp
  • C to T, chromosome 12 at 84,789,083 bp
  • C to T, chromosome 12 at 109,594,679 bp
  • C to A, chromosome 12 at 111,833,178 bp
  • C to T, chromosome 12 at 112,914,258 bp
  • A to T, chromosome 13 at 19,336,726 bp
  • ACTTCTTCT to ACTTCT, chromosome 13 at 59,649,576 bp
  • A to G, chromosome 13 at 69,631,290 bp
  • G to T, chromosome 13 at 102,798,078 bp
  • C to T, chromosome 13 at 102,804,647 bp
  • T to C, chromosome 15 at 9,597,340 bp
  • T to A, chromosome 15 at 75,618,461 bp
  • A to G, chromosome 17 at 71,709,613 bp
  • T to C, chromosome 18 at 7,273,155 bp
  • T to C, chromosome 18 at 36,196,446 bp
  • A to C, chromosome 19 at 15,981,738 bp
  • A to T, chromosome 19 at 32,012,513 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6968 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045078-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.