Strain Name:
C57BL/6J-MtgxR6981Btlr/Mmmh
Stock Number:
045089-MU
Citation ID:
RRID:MMRRC_045089-MU
Other Names:
R6981 (G1)
Major Collection:

Strain Information

Cfl1
Name: cofilin 1, non-muscle
Synonyms: cofilin, Cof, n-cofilin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12631
HGNC: HGNC:1874
Homologene: 99735
Foxj2
Name: forkhead box J2
Synonyms: Fhx
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 60611
Homologene: 10187
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Fnra, Cd49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Dgkh
Name: diacylglycerol kinase, eta
Synonyms: 5930402B05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380921
VEGA: 14
HGNC: HGNC:2854
Homologene: 99373
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Dusp12
Name: dual specificity phosphatase 12
Synonyms: VH1, mVH1, 1190004O14Rik, ESTM36, LMW-DSP4, T-DSP4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80915
HGNC: HGNC:3067
Homologene: 5238
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: WBSCR11, Cream1, GTF3, MusTRD1, binding factor for early enhancer, BEN, ESTM9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75788
Homologene: 10712
Cep85
Name: centrosomal protein 85
Synonyms: 2410030J07Rik, Ccdc21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70012
Homologene: 11254
Dlx1
Name: distal-less homeobox 1
Synonyms: DII B, Dlx, Dlx-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13390
HGNC: HGNC:2914
Homologene: 22558
Gpc6
Name: glypican 6
Synonyms: 6720429C22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 23888
HGNC: HGNC:4454
Homologene: 55922
Knstrn
Name: kinetochore-localized astrin/SPAG5 binding
Synonyms: 1700025D04Rik, D2Ertd750e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51944
Homologene: 12198
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PTIP, D5Ertd149e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, 3000002A17Rik, X83317, Crsp3, Sur2, sno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74552
Homologene: 10722
Zfp958
Name: zinc finger protein 958
Synonyms: BC003267
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 233987
Homologene: 129582
Zyx
Name: zyxin
Synonyms: R75157
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22793
Homologene: 31164
Hspa1a
Name: heat shock protein 1A
Synonyms: Hsp70.3, Hsp70-3, Hsp68, Hsp70a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193740
Homologene: 74294
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ces1h
Name: carboxylesterase 1H
Synonyms: 2310039D24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75704
HGNC: HGNC:1863
Homologene: 119757
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Slc45a1
Name: solute carrier family 45, member 1
Synonyms: Dnb5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242773
Homologene: 44908
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214593
Homologene: 9689
Ache
Name: acetylcholinesterase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11423
HGNC: HGNC:108
Homologene: 543
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66898
Homologene: 23123
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik, Cspg4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Klhl32
Name: kelch-like 32
Synonyms: LOC384000, D4Ertd389e, 6430524H05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212390
Homologene: 14173
Cdh4
Name: cadherin 4
Synonyms: Rcad, R-cadherin, R-Cadh
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, Asef, C230030N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: D330017N19Rik, Srd5a2l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243078
Homologene: 27549
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 403088
Homologene: 74374
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Dhx34
Name: DExH-box helicase 34
Synonyms: Ddx34, 1200013B07Rik, 1810012L18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71723
Homologene: 69171
Acvrl1
Name: activin A receptor, type II-like 1
Synonyms: Alk1, activin receptor-like kinase-1, Acvrlk1, Alk-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11482
HGNC: HGNC:175
Homologene: 20058
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: Kv2.2, 9630047L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
5031439G07Rik
Name: RIKEN cDNA 5031439G07 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223739
HGNC: HGNC:1314
Homologene: 15140
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Tmem171
Name: transmembrane protein 171
Synonyms: LOC380863
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380863
Homologene: 18301
Or4k41
Name: olfactory receptor family 4 subfamily K member 41
Synonyms: GA_x6K02T2Q125-72500603-72501520, MOR248-15, Olfr1287
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257935
Zfp28
Name: zinc finger protein 28
Synonyms: mkr-5, Zfp-28, 2810438M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22690
Homologene: 69047
Proser2
Name: proline and serine rich 2
Synonyms: 5430407P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227545
Homologene: 51648
Or10a5
Name: olfactory receptor family 10 subfamily A member 5
Synonyms: GA_x6K02T2PBJ9-9415724-9416677, MOR263-1, P3, Olfr713
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259036
Homologene: 17470
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 5330407H02Rik, 4930471A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Or5g27
Name: olfactory receptor family 5 subfamily G member 27
Synonyms: GA_x6K02T2Q125-47058060-47059004, MOR175-4, Olfr996
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258429
Homologene: 85934
H2ac12
Name: H2A clustered histone 12
Synonyms: Hist1h2ah
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319168
Homologene: 119667
Asgr2
Name: asialoglycoprotein receptor 2
Synonyms: Asgr-2, Asgr, ASGPR2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11890
HGNC: HGNC:743
Homologene: 912
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Car8
Name: carbonic anhydrase 8
Synonyms: Carp, Cals1, CA-RP VIII, wdl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12319
HGNC: HGNC:1382
Homologene: 20861
Vmn1r16
Name: vomeronasal 1 receptor 16
Synonyms: V1rc29
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171202
Homologene: 123821
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Tmem17
Name: transmembrane protein 17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103765
Homologene: 17795
Ubqln5
Name: ubiquilin 5
Synonyms: 4931431F19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70980
Homologene: 78030
Ccne1
Name: cyclin E1
Synonyms: cyclin E, CycE1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12447
HGNC: HGNC:1589
Homologene: 14452
Gpr15
Name: G protein-coupled receptor 15
Synonyms: 4933439K08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71223
VEGA: 16
HGNC: HGNC:4469
Homologene: 3869
Carns1
Name: carnosine synthase 1
Synonyms: Atpgd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107239
VEGA: 19
Homologene: 26439
Or2b2
Name: olfactory receptor family 2 subfamily B member 2
Synonyms: GA_x6K02T2QHY8-11534186-11533245, MOR256-60, MOR256-35, Olfr1359
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258067
Homologene: 11056
Gm17728
Name: predicted gene, 17728
Type: Gene
Species: Mouse
Chromosome: 17
Ighv1-18
Name: immunoglobulin heavy variable V1-18
Synonyms: Gm16856
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629871
Eppk1
Name: epiplakin 1
Synonyms: EPIPL1, EPPK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 4,345,655 bp
  • T to C, chromosome 1 at 15,710,256 bp
  • A to C, chromosome 1 at 34,722,452 bp
  • T to C, chromosome 1 at 75,430,913 bp
  • C to T, chromosome 1 at 127,390,851 bp
  • A to G, chromosome 1 at 170,880,961 bp
  • T to C, chromosome 2 at 6,113,990 bp
  • T to A, chromosome 2 at 25,444,139 bp
  • C to A, chromosome 2 at 71,532,353 bp
  • A to G, chromosome 2 at 76,861,177 bp
  • A to G, chromosome 2 at 85,579,481 bp
  • T to C, chromosome 2 at 111,449,352 bp
  • T to G, chromosome 2 at 118,834,094 bp
  • A to G, chromosome 2 at 122,291,227 bp
  • C to T, chromosome 2 at 179,797,504 bp
  • T to A, chromosome 3 at 20,022,820 bp
  • T to C, chromosome 3 at 93,148,135 bp
  • A to T, chromosome 4 at 8,185,650 bp
  • T to G, chromosome 4 at 24,709,030 bp
  • C to T, chromosome 4 at 134,152,261 bp
  • A to G, chromosome 4 at 135,479,547 bp
  • T to C, chromosome 4 at 150,638,594 bp
  • G to A, chromosome 5 at 27,765,768 bp
  • T to C, chromosome 5 at 83,354,921 bp
  • G to T, chromosome 5 at 134,383,922 bp
  • C to T, chromosome 5 at 137,291,678 bp
  • T to A, chromosome 5 at 144,285,579 bp
  • A to G, chromosome 5 at 144,886,369 bp
  • G to T, chromosome 5 at 150,048,848 bp
  • T to A, chromosome 6 at 42,350,357 bp
  • G to T, chromosome 6 at 42,597,125 bp
  • T to A, chromosome 6 at 57,323,488 bp
  • T to C, chromosome 6 at 73,021,178 bp
  • A to G, chromosome 6 at 122,828,444 bp
  • A to G, chromosome 6 at 122,842,839 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • C to A, chromosome 7 at 6,394,693 bp
  • G to T, chromosome 7 at 16,215,330 bp
  • A to T, chromosome 7 at 38,098,573 bp
  • A to G, chromosome 7 at 81,477,993 bp
  • A to G, chromosome 7 at 104,128,601 bp
  • T to A, chromosome 7 at 107,036,749 bp
  • A to G, chromosome 8 at 4,626,170 bp
  • T to C, chromosome 8 at 93,353,495 bp
  • A to G, chromosome 8 at 110,531,072 bp
  • T to C, chromosome 9 at 21,845,550 bp
  • A to G, chromosome 9 at 56,887,101 bp
  • T to A, chromosome 10 at 24,895,824 bp
  • T to A, chromosome 11 at 22,518,508 bp
  • G to A, chromosome 11 at 58,293,718 bp
  • C to T, chromosome 11 at 70,096,810 bp
  • T to C, chromosome 11 at 106,202,737 bp
  • A to G, chromosome 12 at 114,682,678 bp
  • A to G, chromosome 13 at 21,703,073 bp
  • A to G, chromosome 13 at 22,035,549 bp
  • A to G, chromosome 13 at 98,692,468 bp
  • A to T, chromosome 14 at 78,627,742 bp
  • T to C, chromosome 14 at 117,624,548 bp
  • T to C, chromosome 15 at 76,111,037 bp
  • A to C, chromosome 15 at 84,949,597 bp
  • A to G, chromosome 15 at 101,138,345 bp
  • T to A, chromosome 15 at 103,350,226 bp
  • T to A, chromosome 16 at 58,718,185 bp
  • A to G, chromosome 17 at 9,422,159 bp
  • A to T, chromosome 17 at 19,793,477 bp
  • A to T, chromosome 17 at 34,970,291 bp
  • T to C, chromosome 19 at 4,170,082 bp
  • T to A, chromosome 19 at 5,492,616 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6981 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045089-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.