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Strain Name:
C57BL/6J-MtgxR6983Btlr/Mmmh
Stock Number:
045090-MU
Citation ID:
RRID:MMRRC_045090-MU
Other Names:
R6983 (G1)
Major Collection:

Strain Information

Ntf3
Name: neurotrophin 3
Synonyms: NT-3, Ntf-3, NT3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18205
HGNC: HGNC:8023
Homologene: 1896
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Diaph1
Name: diaphanous related formin 1
Synonyms: p140mDia, Drf1, Dia1, D18Wsu154e, mDia1, Diap1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,439,041 bp
  • A to G, chromosome 1 at 136,220,156 bp
  • A to T, chromosome 1 at 164,194,129 bp
  • A to T, chromosome 2 at 29,787,784 bp
  • G to T, chromosome 2 at 61,811,735 bp
  • A to G, chromosome 2 at 76,766,962 bp
  • A to T, chromosome 2 at 87,509,579 bp
  • A to G, chromosome 2 at 111,228,250 bp
  • A to T, chromosome 2 at 118,119,952 bp
  • T to C, chromosome 3 at 64,081,697 bp
  • T to A, chromosome 3 at 70,028,041 bp
  • G to A, chromosome 3 at 88,552,839 bp
  • A to T, chromosome 3 at 97,718,236 bp
  • T to A, chromosome 4 at 46,395,997 bp
  • T to A, chromosome 4 at 57,709,973 bp
  • T to C, chromosome 4 at 86,799,493 bp
  • T to C, chromosome 4 at 108,024,273 bp
  • A to G, chromosome 4 at 129,720,842 bp
  • T to G, chromosome 5 at 8,978,280 bp
  • A to T, chromosome 5 at 31,040,405 bp
  • A to C, chromosome 5 at 38,391,721 bp
  • T to G, chromosome 5 at 115,994,091 bp
  • A to G, chromosome 5 at 124,133,406 bp
  • T to C, chromosome 5 at 140,193,984 bp
  • C to T, chromosome 6 at 91,504,023 bp
  • C to A, chromosome 6 at 124,540,896 bp
  • T to C, chromosome 6 at 126,101,845 bp
  • C to T, chromosome 6 at 137,449,917 bp
  • T to C, chromosome 6 at 140,637,663 bp
  • G to A, chromosome 7 at 56,106,453 bp
  • C to T, chromosome 7 at 103,346,815 bp
  • T to C, chromosome 7 at 120,354,463 bp
  • T to C, chromosome 7 at 126,489,435 bp
  • T to A, chromosome 7 at 144,081,848 bp
  • A to T, chromosome 8 at 31,118,460 bp
  • T to C, chromosome 8 at 68,794,051 bp
  • T to A, chromosome 8 at 85,009,776 bp
  • T to A, chromosome 8 at 85,091,071 bp
  • T to A, chromosome 8 at 86,624,248 bp
  • G to A, chromosome 9 at 3,477,817 bp
  • T to C, chromosome 9 at 54,946,509 bp
  • T to C, chromosome 10 at 14,431,695 bp
  • G to T, chromosome 10 at 43,999,342 bp
  • G to A, chromosome 11 at 6,402,413 bp
  • T to C, chromosome 11 at 70,520,284 bp
  • T to A, chromosome 11 at 77,845,515 bp
  • T to C, chromosome 11 at 79,501,938 bp
  • T to C, chromosome 11 at 88,073,319 bp
  • G to A, chromosome 12 at 33,042,380 bp
  • T to A, chromosome 12 at 44,283,247 bp
  • A to C, chromosome 12 at 52,887,653 bp
  • G to T, chromosome 13 at 19,190,644 bp
  • T to A, chromosome 13 at 31,627,197 bp
  • C to A, chromosome 13 at 75,761,887 bp
  • G to T, chromosome 14 at 70,508,207 bp
  • A to T, chromosome 14 at 101,637,052 bp
  • A to G, chromosome 15 at 66,693,358 bp
  • A to T, chromosome 16 at 37,831,618 bp
  • T to C, chromosome 17 at 13,881,321 bp
  • T to C, chromosome 17 at 29,338,776 bp
  • T to A, chromosome 17 at 32,797,432 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • A to T, chromosome 18 at 37,889,769 bp
  • A to T, chromosome 19 at 6,260,040 bp
  • C to T, chromosome 19 at 6,321,668 bp
  • A to G, chromosome 19 at 8,755,169 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6983 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045090-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.