Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6985Btlr/Mmmh
Stock Number:
045092-MU
Citation ID:
RRID:MMRRC_045092-MU
Other Names:
R6985 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Enc1
Name: ectodermal-neural cortex 1
Synonyms: PIG10, Nrpb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13803
VEGA: 13
HGNC: HGNC:3345
Homologene: 2694
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,190,853 bp
  • G to A, chromosome 1 at 34,819,708 bp
  • A to C, chromosome 1 at 72,658,482 bp
  • A to G, chromosome 1 at 75,366,787 bp
  • T to C, chromosome 1 at 92,943,424 bp
  • T to G, chromosome 2 at 11,590,693 bp
  • T to G, chromosome 2 at 34,432,110 bp
  • T to G, chromosome 2 at 85,191,930 bp
  • T to A, chromosome 2 at 91,668,198 bp
  • A to G, chromosome 2 at 118,606,614 bp
  • T to A, chromosome 2 at 148,396,249 bp
  • G to C, chromosome 3 at 30,751,123 bp
  • T to A, chromosome 3 at 64,015,539 bp
  • T to A, chromosome 3 at 87,389,650 bp
  • A to G, chromosome 4 at 123,736,856 bp
  • G to C, chromosome 5 at 33,735,441 bp
  • T to A, chromosome 5 at 138,278,408 bp
  • T to G, chromosome 6 at 5,168,345 bp
  • A to G, chromosome 6 at 32,237,708 bp
  • A to G, chromosome 6 at 106,679,417 bp
  • C to A, chromosome 7 at 30,455,306 bp
  • A to G, chromosome 7 at 44,344,913 bp
  • G to A, chromosome 7 at 56,106,453 bp
  • A to G, chromosome 7 at 56,132,480 bp
  • A to G, chromosome 7 at 103,603,668 bp
  • G to A, chromosome 7 at 116,417,988 bp
  • A to G, chromosome 7 at 135,163,403 bp
  • A to G, chromosome 7 at 135,713,865 bp
  • C to A, chromosome 7 at 144,452,587 bp
  • T to A, chromosome 8 at 3,161,372 bp
  • T to C, chromosome 8 at 70,505,905 bp
  • T to C, chromosome 8 at 95,734,129 bp
  • T to C, chromosome 9 at 54,708,395 bp
  • T to G, chromosome 9 at 72,851,501 bp
  • G to A, chromosome 9 at 90,054,604 bp
  • C to A, chromosome 10 at 53,021,911 bp
  • A to G, chromosome 10 at 126,014,869 bp
  • A to G, chromosome 11 at 17,946,108 bp
  • A to T, chromosome 11 at 21,996,615 bp
  • T to C, chromosome 11 at 58,817,113 bp
  • T to C, chromosome 11 at 99,385,630 bp
  • T to C, chromosome 11 at 106,818,703 bp
  • T to C, chromosome 12 at 111,812,096 bp
  • T to C, chromosome 12 at 114,896,632 bp
  • G to T, chromosome 13 at 19,190,644 bp
  • T to A, chromosome 13 at 59,627,943 bp
  • T to C, chromosome 13 at 59,703,093 bp
  • T to A, chromosome 13 at 59,731,615 bp
  • T to C, chromosome 13 at 80,883,657 bp
  • T to C, chromosome 13 at 89,679,956 bp
  • T to C, chromosome 13 at 93,663,322 bp
  • C to T, chromosome 13 at 97,245,120 bp
  • G to T, chromosome 14 at 20,471,568 bp
  • A to T, chromosome 14 at 33,099,117 bp
  • C to T, chromosome 14 at 103,206,681 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to C, chromosome 15 at 96,370,148 bp
  • A to T, chromosome 16 at 32,751,999 bp
  • A to G, chromosome 16 at 48,754,271 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • A to G, chromosome 17 at 80,636,732 bp
  • A to G, chromosome 18 at 37,497,158 bp
  • A to T, chromosome 18 at 58,068,388 bp
  • A to T, chromosome 18 at 59,176,488 bp
  • T to C, chromosome 18 at 74,653,361 bp
  • T to A, chromosome 19 at 6,481,245 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6985 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045092-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.