Strain Name:
C57BL/6J-MtgxR6985Btlr/Mmmh
Stock Number:
045092-MU
Citation ID:
RRID:MMRRC_045092-MU
Other Names:
R6985 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Vcan
Name: versican
Synonyms: Cspg2, hdf, PG-M, heart defect, DPEAAE, 5430420N07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Enc1
Name: ectodermal-neural cortex 1
Synonyms: Nrpb, PIG10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13803
VEGA: 13
HGNC: HGNC:3345
Homologene: 2694
Nrxn2
Name: neurexin II
Synonyms: neurexin II alpha, 6430591O13Rik, neurexin II beta
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Dst
Name: dystonin
Synonyms: Bpag, Macf2, A830042E19Rik, nmf339, 2310001O04Rik, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, athetoid, nmf203, Bpag1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, 4921505C17Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Dock1
Name: dedicator of cytokinesis 1
Synonyms: b2b3190Clo, 9130006G06Rik, D630004B07Rik, Dock180
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9430095K15Rik, 9030421L11Rik, 9130004I02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: D230039K05Rik, Sin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227743
Homologene: 11473
Prtg
Name: protogenin
Synonyms: Igdcc5, A230098A12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68145
Homologene: 10369
Arid2
Name: AT-rich interaction domain 2
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, jdf2, D15F32S1h, D7H15F32S1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Pon1
Name: paraoxonase 1
Synonyms: Pon
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18979
HGNC: HGNC:9204
Homologene: 68058
Arrdc3
Name: arrestin domain containing 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105171
Homologene: 69318
Samd7
Name: sterile alpha motif domain containing 7
Synonyms: 4930597A01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75953
Homologene: 18802
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Cttn
Name: cortactin
Synonyms: Ems1, 1110020L01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13043
HGNC: HGNC:3338
Homologene: 3834
Krt10
Name: keratin 10
Synonyms: keratin 10, K1C1, K10, Krt-1.10, suprabasal cytokeratin 10, cytokeratin 10, Krt1-10, D130054E02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16661
HGNC: HGNC:6413
Homologene: 137236
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: Fgfr-3, HBGFR, sam3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Lrrc55
Name: leucine rich repeat containing 55
Synonyms: A330097E02Rik, LOC241528
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241528
VEGA: 2
Homologene: 19385
Fcrl1
Name: Fc receptor-like 1
Synonyms: A230020G22Rik, mBXMH1, moFcRH1L, moFcRH1S, mIFGP1, IFGP1, Fcrh1, moFcRH1, BXMAS1-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229499
Homologene: 50472
Kirrel2
Name: kirre like nephrin family adhesion molecule 2
Synonyms: NEPH3, C330019F22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243911
Homologene: 35249
Anxa7
Name: annexin A7
Synonyms: Anx7, synexin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11750
VEGA: 14
HGNC: HGNC:545
Homologene: 36149
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: A330027C19Rik, C030004C14Rik, A330021G12Rik, Mak10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78689
Homologene: 5781
Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
Synonyms: 9530052P13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225028
VEGA: 17
HGNC: HGNC:6865
Homologene: 2683
Cep95
Name: centrosomal protein 95
Synonyms: F630025I20Rik, Ccdc45, 4732496G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320162
Homologene: 16297
Arhgap1
Name: Rho GTPase activating protein 1
Synonyms: Cdc42GAP, B230365D05Rik, p50rhoGAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228359
HGNC: HGNC:673
Homologene: 20909
Fam168b
Name: family with sequence similarity 168, member B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214469
Homologene: 18390
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Fbn2
Name: fibrillin 2
Synonyms: Sne, sy, Fib-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Insr
Name: insulin receptor
Synonyms: D630014A15Rik, CD220, IR-A, IR-B, 4932439J01Rik, IR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Cntn4
Name: contactin 4
Synonyms: Axcam, BIG-2A
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Pcdhb19
Name: protocadherin beta 19
Synonyms: PcdhbS, Pcdhb11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93890
Homologene: 128411
Rbm17
Name: RNA binding motif protein 17
Synonyms: 2700027J02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76938
Homologene: 13162
Or5af2
Name: olfactory receptor family 5 subfamily AC member 20
Synonyms: MOR222-2, GA_x6K02T2NKPP-590035-589109, Olfr313
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258529
Homologene: 77375
Ctsh
Name: cathepsin H
Synonyms: Cat H
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13036
HGNC: HGNC:2535
Homologene: 36159
Sstr4
Name: somatostatin receptor 4
Synonyms: sst4, Smstr4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20608
Homologene: 20286
Xrcc3
Name: X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms: 4432412E01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74335
Homologene: 36178
Gpc2
Name: glypican 2 cerebroglycan
Synonyms: 2410016G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71951
HGNC: HGNC:4450
Homologene: 17657
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215085
Homologene: 33552
Capn10
Name: calpain 10
Synonyms: Capn8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23830
HGNC: HGNC:1477
Homologene: 36323
Trat1
Name: T cell receptor associated transmembrane adaptor 1
Synonyms: Tcrim, Trim, C030046M14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77647
VEGA: 16
Homologene: 41130
Bhmt2
Name: betaine-homocysteine methyltransferase 2
Synonyms: D13Ucla2, C81077
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 64918
HGNC: HGNC:1048
Homologene: 49496
Or52z14
Name: olfactory receptor family 52 subfamily Z member 14
Synonyms: GA_x6K02T2PBJ9-6326488-6327450, MOR31-5, Olfr619
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259080
Homologene: 45095
Akirin1
Name: akirin 1
Synonyms: 6330407G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68050
Homologene: 11348
Dnaja4
Name: DnaJ heat shock protein family (Hsp40) member A4
Synonyms: Hsj4, Dj4, 1110021L12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58233
Homologene: 23110
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: Fam75d3, Fam75d1a, 1700013B16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Spata31d1d
Name: spermatogenesis associated 31 subfamily D, member 1D
Synonyms: Fam75d1d, 4932411G14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238663
Homologene: 129932
Ighv1-37
Name: immunoglobulin heavy variable 1-37
Synonyms: Gm16716
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668517
HGNC: HGNC:5553
Rex1bd
Name: required for excision 1-B domain containing
Synonyms: 2810428I15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66462
Homologene: 11974
Trgv6
Name: T cell receptor gamma, variable 6
Synonyms: Tcrg-V6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21640
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,190,853 bp
  • G to A, chromosome 1 at 34,819,708 bp
  • A to C, chromosome 1 at 72,658,482 bp
  • A to G, chromosome 1 at 75,366,787 bp
  • T to C, chromosome 1 at 92,943,424 bp
  • T to G, chromosome 2 at 11,590,693 bp
  • T to G, chromosome 2 at 34,432,110 bp
  • T to G, chromosome 2 at 85,191,930 bp
  • T to A, chromosome 2 at 91,668,198 bp
  • A to G, chromosome 2 at 118,606,614 bp
  • T to A, chromosome 2 at 148,396,249 bp
  • G to C, chromosome 3 at 30,751,123 bp
  • T to A, chromosome 3 at 64,015,539 bp
  • T to A, chromosome 3 at 87,389,650 bp
  • A to G, chromosome 4 at 123,736,856 bp
  • G to C, chromosome 5 at 33,735,441 bp
  • T to A, chromosome 5 at 138,278,408 bp
  • T to G, chromosome 6 at 5,168,345 bp
  • A to G, chromosome 6 at 32,237,708 bp
  • A to G, chromosome 6 at 106,679,417 bp
  • C to A, chromosome 7 at 30,455,306 bp
  • A to G, chromosome 7 at 44,344,913 bp
  • G to A, chromosome 7 at 56,106,453 bp
  • A to G, chromosome 7 at 56,132,480 bp
  • A to G, chromosome 7 at 103,603,668 bp
  • G to A, chromosome 7 at 116,417,988 bp
  • A to G, chromosome 7 at 135,163,403 bp
  • A to G, chromosome 7 at 135,713,865 bp
  • C to A, chromosome 7 at 144,452,587 bp
  • T to A, chromosome 8 at 3,161,372 bp
  • T to C, chromosome 8 at 70,505,905 bp
  • T to C, chromosome 8 at 95,734,129 bp
  • T to C, chromosome 9 at 54,708,395 bp
  • T to G, chromosome 9 at 72,851,501 bp
  • G to A, chromosome 9 at 90,054,604 bp
  • C to A, chromosome 10 at 53,021,911 bp
  • A to G, chromosome 10 at 126,014,869 bp
  • A to G, chromosome 11 at 17,946,108 bp
  • A to T, chromosome 11 at 21,996,615 bp
  • T to C, chromosome 11 at 58,817,113 bp
  • T to C, chromosome 11 at 99,385,630 bp
  • T to C, chromosome 11 at 106,818,703 bp
  • T to C, chromosome 12 at 111,812,096 bp
  • T to C, chromosome 12 at 114,896,632 bp
  • G to T, chromosome 13 at 19,190,644 bp
  • T to A, chromosome 13 at 59,627,943 bp
  • T to C, chromosome 13 at 59,703,093 bp
  • T to A, chromosome 13 at 59,731,615 bp
  • T to C, chromosome 13 at 80,883,657 bp
  • T to C, chromosome 13 at 89,679,956 bp
  • T to C, chromosome 13 at 93,663,322 bp
  • C to T, chromosome 13 at 97,245,120 bp
  • G to T, chromosome 14 at 20,471,568 bp
  • A to T, chromosome 14 at 33,099,117 bp
  • C to T, chromosome 14 at 103,206,681 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to C, chromosome 15 at 96,370,148 bp
  • A to T, chromosome 16 at 32,751,999 bp
  • A to G, chromosome 16 at 48,754,271 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • A to G, chromosome 17 at 80,636,732 bp
  • A to G, chromosome 18 at 37,497,158 bp
  • A to T, chromosome 18 at 58,068,388 bp
  • A to T, chromosome 18 at 59,176,488 bp
  • T to C, chromosome 18 at 74,653,361 bp
  • T to A, chromosome 19 at 6,481,245 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6985 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045092-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.