Strain Name:
C57BL/6J-MtgxR6986Btlr/Mmmh
Stock Number:
045093-MU
Citation ID:
RRID:MMRRC_045093-MU
Other Names:
R6986 (G1)
Major Collection:

Strain Information

Mtmr3
Name: myotubularin related protein 3
Synonyms: FYVE-DSP1, 1700092A20Rik, ZFYVE10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74302
HGNC: HGNC:7451
Homologene: 23662
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra-5, Acra5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Adcy9
Name: adenylate cyclase 9
Synonyms: D16Wsu65e, ACtp10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Irf1
Name: interferon regulatory factor 1
Synonyms: Irf-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16362
HGNC: HGNC:6116
Homologene: 1658
Mtarc2
Name: mitochondrial amidoxime reducing component 2
Synonyms: 2810484M10Rik, Mosc2, Marc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67247
Homologene: 9904
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: ZMYND8, 2010005I16Rik, 1110013E22Rik, 3632413B07Rik, RACK7, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Serinc3
Name: serine incorporator 3
Synonyms: TMS-1, DIFF33, AIGP1, Tde1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26943
Homologene: 38230
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Nckap1
Name: NCK-associated protein 1
Synonyms: mh19, Hem-2, H19, Nap1, Hem2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, pet, hypothroid
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Ehd4
Name: EH-domain containing 4
Synonyms: 2210022F10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98878
HGNC: HGNC:3245
Homologene: 26430
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Cux2
Name: cut-like homeobox 2
Synonyms: Cux-2, Cux2, ENSMUSG00000072641, Cutl2, 1700051K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329252
Homologene: 49680
St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
Synonyms: Prss14, Epithin, MT-SP1, matriptase, Tmprss14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19143
Homologene: 7906
H3c8
Name: H3 clustered histone 8
Synonyms: H3.1-221, M32460, Hist1h3g
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97908
Homologene: 134479
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: 145kDa, SF3b150, SF3b145, SAP145, SF3b1, B230398H18Rik, 2810441F20Rik, 2610311M13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Smox
Name: spermine oxidase
Synonyms: B130066H01Rik, SMO
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228608
Homologene: 69268
Ell2
Name: elongation factor for RNA polymerase II 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 192657
VEGA: 13
Homologene: 8094
Rnase9
Name: ribonuclease, RNase A family, 9 (non-active)
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328401
VEGA: 14
Homologene: 18830
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66661
Homologene: 38254
Ncdn
Name: neurochondrin
Synonyms: neurochondrin-2, neurochondrin-1, norbin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26562
Homologene: 8064
Trpc3
Name: transient receptor potential cation channel, subfamily C, member 3
Synonyms: Trp3, Trrp3, Trcp3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22065
Homologene: 20708
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, 6530406M24Rik, 4930431N21Rik, Ccp3, Ccp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74183
Homologene: 135954
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 638695
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625029
Homologene: 83669
Ss18l2
Name: SS18, nBAF chromatin remodeling complex subunit like 2
Synonyms: Band 47B, 1110020I04Rik, Deb1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26901
VEGA: 9
Homologene: 32307
Or2w25
Name: olfactory receptor family 2 subfamily W member 25
Synonyms: GA_x6K02T0073K-490-1545, MOR256-51, Olfr225
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257886
Homologene: 105324
Cgrrf1
Name: cell growth regulator with ring finger domain 1
Synonyms: 1110038G02Rik, CGR19, 1810009H17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68755
Homologene: 4789
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665210
Homologene: 115024
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: D630003G22Rik, Rutbc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 97761
Homologene: 14780
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: Cark, D830019J24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 435766
Homologene: 41084
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Pramel14
Name: PRAME like 14
Synonyms: Gm13107, Pramef17
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 626943
Homologene: 129642
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231147
Homologene: 10360
Or6c69c
Name: olfactory receptor family 6 subfamily C member 69C
Synonyms: GA_x6K02T2PULF-11745102-11746040, MOR113-2, Olfr822
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258666
Homologene: 133890
Gm6370
Name: predicted gene 6370
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622924
Homologene: 86127
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209966
Homologene: 11583
Polr2k
Name: polymerase (RNA) II (DNA directed) polypeptide K
Synonyms: MafY, ABC10-alpha, RPB10alpha, RPB7.0, RPABC4, RPB12, Mt1a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17749
HGNC: HGNC:9198
Homologene: 86049
Spata31f3
Name: spermatogenesis associated 31 subfamily F member 3
Synonyms: BC049635, Fam205c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277773
Homologene: 77625
Aldh3a1
Name: aldehyde dehydrogenase family 3, subfamily A1
Synonyms: Ahd-4, Ahd4, Aldh3, Aldh
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11670
HGNC: HGNC:405
Homologene: 20175
Zfp9
Name: zinc finger protein 9
Synonyms: Krox-4, 1810048F22Rik, Zfp-9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22750
Homologene: 49280
Celf3
Name: CUGBP, Elav-like family member 3
Synonyms: BRUNOL1, ERDA4, CAGH4, 4930415M08Rik, Tnrc4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78784
Homologene: 48510
Endod1
Name: endonuclease domain containing 1
Synonyms: 2210414F18Rik, 2310067E08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71946
VEGA: 9
Homologene: 12425
Optc
Name: opticin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Rnls
Name: renalase, FAD-dependent amine oxidase
Synonyms: 6530404N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67795
Homologene: 41254
Cyb5rl
Name: cytochrome b5 reductase-like
Synonyms: 2810410C14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230582
Homologene: 45506
Snrpa
Name: small nuclear ribonucleoprotein polypeptide A
Synonyms: U1A, U1 snRNP, Rnu1a1, C430021M15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53607
Homologene: 133537
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Morn4
Name: MORN repeat containing 4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226123
VEGA: 19
Homologene: 16635
Ppp2r3d
Name: protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta
Synonyms: PR59, Ppp2r3, Ppp2r3a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19054
Tuft1
Name: tuftelin 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22156
Homologene: 7985
Trgv6
Name: T cell receptor gamma, variable 6
Synonyms: Tcrg-V6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21640
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 133,897,964 bp
  • G to T, chromosome 1 at 134,993,956 bp
  • T to C, chromosome 1 at 184,841,263 bp
  • A to T, chromosome 2 at 65,508,618 bp
  • T to A, chromosome 2 at 80,520,567 bp
  • A to T, chromosome 2 at 120,097,090 bp
  • C to T, chromosome 2 at 131,522,111 bp
  • A to G, chromosome 2 at 163,627,971 bp
  • G to T, chromosome 2 at 165,833,415 bp
  • A to G, chromosome 3 at 36,655,016 bp
  • G to C, chromosome 3 at 94,487,717 bp
  • G to A, chromosome 3 at 94,614,154 bp
  • C to T, chromosome 3 at 154,961,864 bp
  • T to A, chromosome 4 at 8,859,285 bp
  • T to C, chromosome 4 at 11,204,474 bp
  • A to G, chromosome 4 at 42,868,696 bp
  • T to A, chromosome 4 at 107,070,876 bp
  • A to G, chromosome 4 at 126,747,229 bp
  • T to A, chromosome 4 at 143,993,318 bp
  • A to T, chromosome 4 at 156,218,519 bp
  • A to G, chromosome 5 at 35,723,944 bp
  • T to A, chromosome 5 at 76,994,876 bp
  • A to T, chromosome 5 at 121,868,579 bp
  • T to A, chromosome 5 at 146,493,588 bp
  • A to G, chromosome 6 at 34,839,452 bp
  • A to G, chromosome 6 at 118,464,465 bp
  • A to T, chromosome 7 at 27,192,964 bp
  • G to A, chromosome 7 at 56,106,453 bp
  • T to C, chromosome 7 at 110,330,615 bp
  • T to C, chromosome 8 at 105,458,447 bp
  • C to T, chromosome 8 at 124,384,473 bp
  • T to C, chromosome 9 at 14,357,310 bp
  • G to A, chromosome 9 at 16,021,335 bp
  • A to G, chromosome 9 at 31,096,549 bp
  • T to A, chromosome 9 at 55,006,457 bp
  • A to G, chromosome 9 at 121,712,605 bp
  • A to T, chromosome 9 at 124,439,080 bp
  • G to T, chromosome 10 at 79,480,259 bp
  • G to A, chromosome 10 at 130,075,330 bp
  • T to C, chromosome 11 at 4,489,692 bp
  • A to G, chromosome 11 at 53,774,140 bp
  • A to G, chromosome 11 at 59,614,098 bp
  • T to A, chromosome 11 at 61,214,251 bp
  • T to A, chromosome 11 at 74,892,041 bp
  • C to T, chromosome 12 at 91,533,957 bp
  • T to A, chromosome 12 at 95,780,685 bp
  • G to T, chromosome 13 at 19,190,644 bp
  • A to G, chromosome 13 at 23,535,433 bp
  • C to A, chromosome 13 at 75,761,887 bp
  • T to C, chromosome 14 at 46,832,129 bp
  • T to C, chromosome 14 at 51,039,080 bp
  • T to C, chromosome 14 at 51,365,375 bp
  • C to T, chromosome 14 at 67,694,997 bp
  • C to A, chromosome 15 at 36,175,035 bp
  • T to C, chromosome 16 at 4,311,577 bp
  • A to G, chromosome 17 at 18,136,009 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • A to T, chromosome 17 at 57,509,340 bp
  • A to T, chromosome 17 at 85,985,222 bp
  • T to C, chromosome 18 at 78,857,839 bp
  • T to C, chromosome 19 at 5,279,895 bp
  • T to C, chromosome 19 at 20,824,283 bp
  • C to T, chromosome 19 at 33,382,381 bp
  • T to C, chromosome 19 at 42,078,014 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6986 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045093-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.