Strain Name:
C57BL/6J-MtgxR7008Btlr/Mmmh
Stock Number:
045110-MU
Citation ID:
RRID:MMRRC_045110-MU
Other Names:
R7008 (G1)
Major Collection:

Strain Information

Card11
Name: caspase recruitment domain family, member 11
Synonyms: 0610008L17Rik, CARMA1, 2410011D02Rik, BIMP3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Synonyms: aromatase, Int-5, Cyp19, Int5, p450arom, Ar, ArKO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13075
VEGA: 9
HGNC: HGNC:2594
Homologene: 30955
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: Spar, 4931426N11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 9630045K08Rik, 4733401D09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Cdk7
Name: cyclin dependent kinase 7
Synonyms: Cdkn7, CRK4 PK (CDC2-related-kinase-4 protein kinase), Crk4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12572
VEGA: 13
HGNC: HGNC:1778
Homologene: 1363
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Tdg
Name: thymine DNA glycosylase
Synonyms: Jza1, E130317C12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21665
Homologene: 2415
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Nemf
Name: nuclear export mediator factor
Synonyms: 4933405E14Rik, Sdccag1, 1500011I12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66244
VEGA: 12
Homologene: 3458
Rab5c
Name: RAB5C, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19345
HGNC: HGNC:9785
Homologene: 55533
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2210012C09Rik, 1300004K21Rik, 2310058O11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67867
Homologene: 16944
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: 2700050F09Rik, A430027N15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72587
Homologene: 6372
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Dgcr2
Name: DiGeorge syndrome critical region gene 2
Synonyms: Lan, Dgcr2, 9930034O06Rik, Dgsc, DGS-C, Sez12, Idd
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13356
HGNC: HGNC:2845
Homologene: 31292
Runx2
Name: runt related transcription factor 2
Synonyms: Cbfa1, Pebpa2a, AML3, polyomavirus enhancer binding factor 2 (PEBP2), PEBP2 alpha A, Osf2, SL3-3 enhancer factor 1, PEBP2aA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Plaa
Name: phospholipase A2, activating protein
Synonyms: D4Ertd618e, Ufd3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18786
HGNC: HGNC:9043
Homologene: 3138
Bcl10
Name: B cell leukemia/lymphoma 10
Synonyms: BCL-10, cE10, mE10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12042
HGNC: HGNC:989
Homologene: 2912
Cd2bp2
Name: CD2 cytoplasmic tail binding protein 2
Synonyms: 2410024K20Rik, 1500011B02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70233
HGNC: HGNC:1656
Homologene: 4455
Zfp597
Name: zinc finger protein 597
Synonyms: 4933407K12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71063
Homologene: 33641
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, C820004B04Rik, OPR-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74486
Homologene: 69240
Prss35
Name: serine protease 35
Synonyms: 6030424L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244954
Homologene: 17734
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56747
Homologene: 10895
Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms: DMT1, Nramp2, van, DCT1, microcytic anemia, viable anaemia
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18174
Homologene: 55471
Mthfd2l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Synonyms: 1110019K23Rik, C630010D07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665563
Homologene: 28295
Milr1
Name: mast cell immunoglobulin like receptor 1
Synonyms: Allergin-1, Gm885, LOC380732
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380732
Homologene: 86017
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381693
Homologene: 124480
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Maz
Name: MYC-associated zinc finger protein (purine-binding transcription factor)
Synonyms: Pur-1, SAF-1, PUR1, SAF-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17188
HGNC: HGNC:6914
Homologene: 106451
Zfp385c
Name: zinc finger protein 385C
Synonyms: A930006D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 278304
Homologene: 65334
Trip6
Name: thyroid hormone receptor interactor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22051
Homologene: 37757
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213550
Homologene: 15797
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Trim40
Name: tripartite motif-containing 40
Synonyms: LOC195359, LOC333872, LOC240093
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 195359
Homologene: 34709
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20649
Homologene: 9618
Zfp175
Name: zinc finger protein 175
Synonyms: Zfp658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210104
Homologene: 134007
Osgin1
Name: oxidative stress induced growth inhibitor 1
Synonyms: 1700012B18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71839
Homologene: 16325
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Or5b124
Name: olfactory receptor family 5 subfamily B member 124
Synonyms: GA_x6K02T2RE5P-3965668-3966609, MOR202-19, Olfr1489
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258628
Homologene: 45021
Sting1
Name: stimulator of interferon response cGAMP interactor 1
Synonyms: Sting, ERIS, MPYS, Tmem173, 2610307O08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72512
VEGA: 18
Homologene: 18868
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Nlrc2, F830032C23Rik, Card15
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Or4z4
Name: olfactory receptor family 4 subfamily Z member 4
Synonyms: MOR239-4, Olfr1427, GA_x6K02T2RE5P-2458473-2457538
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258674
Homologene: 128080
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm6976, Gm29096
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Spatc1
Name: spermatogenesis and centriole associated 1
Synonyms: speriolin, 1700084J23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74281
VEGA: 15
Homologene: 129861
Ephb4
Name: Eph receptor B4
Synonyms: MDK2, b2b2412Clo, Htk, Myk1, Tyro11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13846
HGNC: HGNC:3395
Homologene: 20939
Cryba4
Name: crystallin, beta A4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12959
HGNC: HGNC:2396
Homologene: 1422
Rasl12
Name: RAS-like, family 12
Synonyms: 4631404I11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70784
VEGA: 9
Homologene: 9565
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212989
Homologene: 41187
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332579
Homologene: 14150
Tmem252
Name: transmembrane protein 252
Synonyms: E030010A14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226040
VEGA: 19
Homologene: 17717
H1f4
Name: H1.4 linker histone, cluster member
Synonyms: H1-4, H1f4, H1s-4, H1e, H1var2, Hist1h1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50709
HGNC: HGNC:4718
Homologene: 137314
Rdh16f1
Name: RDH16 family member 1
Synonyms: Gm28046
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 39,988,971 bp
  • T to C, chromosome 1 at 44,059,625 bp
  • T to C, chromosome 2 at 26,357,799 bp
  • A to G, chromosome 2 at 62,286,922 bp
  • T to C, chromosome 2 at 76,894,642 bp
  • C to A, chromosome 3 at 87,729,218 bp
  • GGAGAG to GGAG, chromosome 3 at 88,112,771 bp
  • T to C, chromosome 3 at 127,561,772 bp
  • A to G, chromosome 3 at 145,132,734 bp
  • G to T, chromosome 3 at 145,933,299 bp
  • A to G, chromosome 4 at 94,569,349 bp
  • CGG to CG, chromosome 4 at 141,918,291 bp
  • T to C, chromosome 5 at 65,143,249 bp
  • T to A, chromosome 5 at 90,260,096 bp
  • T to A, chromosome 5 at 90,959,728 bp
  • T to A, chromosome 5 at 112,251,782 bp
  • T to C, chromosome 5 at 112,464,695 bp
  • T to C, chromosome 5 at 137,312,966 bp
  • T to A, chromosome 5 at 137,361,274 bp
  • G to C, chromosome 5 at 140,873,393 bp
  • T to A, chromosome 5 at 147,545,693 bp
  • T to C, chromosome 5 at 149,611,540 bp
  • T to C, chromosome 6 at 115,850,724 bp
  • T to G, chromosome 7 at 43,573,912 bp
  • A to T, chromosome 7 at 67,595,711 bp
  • A to T, chromosome 7 at 127,024,612 bp
  • T to C, chromosome 7 at 127,195,395 bp
  • T to A, chromosome 8 at 85,013,211 bp
  • T to A, chromosome 8 at 88,663,657 bp
  • T to C, chromosome 8 at 119,441,494 bp
  • A to T, chromosome 9 at 54,193,325 bp
  • A to G, chromosome 9 at 64,310,453 bp
  • G to A, chromosome 9 at 65,410,869 bp
  • T to C, chromosome 9 at 86,756,308 bp
  • T to G, chromosome 9 at 115,061,848 bp
  • T to A, chromosome 10 at 41,552,415 bp
  • T to A, chromosome 10 at 82,648,641 bp
  • A to G, chromosome 10 at 127,790,906 bp
  • A to T, chromosome 11 at 100,630,687 bp
  • G to A, chromosome 11 at 100,719,963 bp
  • T to A, chromosome 11 at 106,751,314 bp
  • A to T, chromosome 12 at 69,341,621 bp
  • C to T, chromosome 12 at 69,353,793 bp
  • T to G, chromosome 12 at 82,363,112 bp
  • T to C, chromosome 13 at 23,622,209 bp
  • A to C, chromosome 13 at 100,717,621 bp
  • A to T, chromosome 15 at 55,792,072 bp
  • A to G, chromosome 15 at 76,283,723 bp
  • T to C, chromosome 15 at 100,409,324 bp
  • A to G, chromosome 16 at 3,865,767 bp
  • A to G, chromosome 16 at 17,845,001 bp
  • A to T, chromosome 16 at 22,081,832 bp
  • A to T, chromosome 16 at 90,993,945 bp
  • T to C, chromosome 17 at 5,290,979 bp
  • T to C, chromosome 17 at 36,883,976 bp
  • G to A, chromosome 17 at 44,814,192 bp
  • C to A, chromosome 18 at 35,735,171 bp
  • G to A, chromosome 19 at 12,098,850 bp
  • A to T, chromosome 19 at 13,633,621 bp
  • T to C, chromosome 19 at 24,674,292 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7008 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045110-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.