Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7009Btlr/Mmmh
Stock Number:
045111-MU
Citation ID:
RRID:MMRRC_045111-MU
Other Names:
R7009 (G1)
Major Collection:

Strain Information

Otx2
Name: orthodenticle homeobox 2
Synonyms: E130306E05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18424
HGNC: HGNC:8522
Homologene: 11026
Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Srd5a3
Name: steroid 5 alpha-reductase 3
Synonyms: D730040M03Rik, 1110025P14Rik, Srd5a2l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57357
Homologene: 41385
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Rilpl1
Name: Rab interacting lysosomal protein-like 1
Synonyms: 6330559I19Rik, 2900002H16Rik, GOSPEL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75695
Homologene: 15619
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 4,042,068 bp
  • A to G, chromosome 1 at 93,873,759 bp
  • G to A, chromosome 1 at 138,064,553 bp
  • A to G, chromosome 1 at 151,370,630 bp
  • G to T, chromosome 1 at 172,091,000 bp
  • G to T, chromosome 2 at 26,436,002 bp
  • A to G, chromosome 2 at 34,700,817 bp
  • A to G, chromosome 2 at 49,757,429 bp
  • A to G, chromosome 2 at 120,697,191 bp
  • A to G, chromosome 2 at 139,757,279 bp
  • A to C, chromosome 2 at 145,883,475 bp
  • A to G, chromosome 2 at 156,320,034 bp
  • C to A, chromosome 2 at 156,534,683 bp
  • A to G, chromosome 2 at 181,718,381 bp
  • T to C, chromosome 3 at 80,706,972 bp
  • C to A, chromosome 3 at 92,686,046 bp
  • A to G, chromosome 3 at 100,931,879 bp
  • A to T, chromosome 3 at 135,235,201 bp
  • G to A, chromosome 3 at 135,235,202 bp
  • A to T, chromosome 4 at 49,586,325 bp
  • G to A, chromosome 4 at 115,831,582 bp
  • A to G, chromosome 5 at 61,808,891 bp
  • G to A, chromosome 5 at 76,149,866 bp
  • A to T, chromosome 5 at 98,784,520 bp
  • T to C, chromosome 5 at 100,692,279 bp
  • G to A, chromosome 5 at 108,173,862 bp
  • T to A, chromosome 5 at 124,503,692 bp
  • T to C, chromosome 5 at 134,672,699 bp
  • T to A, chromosome 5 at 136,101,363 bp
  • G to A, chromosome 5 at 138,259,112 bp
  • T to C, chromosome 5 at 139,768,462 bp
  • A to T, chromosome 5 at 149,427,243 bp
  • T to A, chromosome 6 at 115,547,972 bp
  • T to C, chromosome 6 at 130,125,184 bp
  • T to A, chromosome 6 at 143,203,154 bp
  • T to C, chromosome 7 at 62,419,618 bp
  • G to A, chromosome 7 at 83,646,388 bp
  • T to C, chromosome 7 at 102,460,334 bp
  • T to C, chromosome 8 at 24,806,438 bp
  • A to G, chromosome 8 at 95,098,384 bp
  • A to T, chromosome 9 at 32,245,976 bp
  • A to G, chromosome 9 at 44,694,408 bp
  • A to T, chromosome 9 at 46,242,880 bp
  • T to G, chromosome 9 at 104,016,116 bp
  • T to G, chromosome 9 at 119,485,930 bp
  • T to A, chromosome 9 at 119,958,073 bp
  • T to A, chromosome 10 at 60,337,306 bp
  • T to A, chromosome 10 at 62,937,454 bp
  • A to T, chromosome 10 at 92,875,019 bp
  • A to T, chromosome 11 at 54,502,935 bp
  • A to C, chromosome 11 at 60,200,526 bp
  • T to C, chromosome 11 at 68,594,616 bp
  • A to G, chromosome 11 at 70,014,791 bp
  • G to A, chromosome 11 at 98,682,766 bp
  • A to T, chromosome 11 at 105,840,699 bp
  • A to T, chromosome 12 at 52,519,639 bp
  • G to A, chromosome 12 at 100,619,537 bp
  • A to T, chromosome 13 at 14,054,165 bp
  • A to G, chromosome 13 at 34,030,062 bp
  • A to T, chromosome 13 at 58,610,804 bp
  • G to T, chromosome 13 at 59,690,810 bp
  • A to G, chromosome 13 at 67,517,054 bp
  • A to T, chromosome 14 at 28,969,365 bp
  • T to A, chromosome 14 at 48,658,797 bp
  • A to G, chromosome 14 at 50,924,708 bp
  • T to C, chromosome 14 at 54,952,292 bp
  • T to C, chromosome 14 at 55,592,551 bp
  • T to A, chromosome 14 at 65,971,832 bp
  • A to T, chromosome 15 at 9,062,984 bp
  • C to T, chromosome 15 at 11,905,248 bp
  • T to A, chromosome 15 at 42,523,595 bp
  • G to A, chromosome 15 at 82,854,682 bp
  • T to A, chromosome 15 at 101,931,441 bp
  • A to C, chromosome 16 at 8,602,367 bp
  • G to T, chromosome 16 at 48,627,070 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • G to A, chromosome 17 at 19,694,194 bp
  • A to G, chromosome 17 at 34,600,736 bp
  • G to A, chromosome 17 at 44,814,192 bp
  • C to A, chromosome 18 at 65,722,538 bp
  • C to T, chromosome 19 at 8,605,417 bp
  • C to T, chromosome 19 at 24,359,935 bp
  • T to C, chromosome 19 at 47,113,142 bp
  • T to C, chromosome 19 at 55,894,733 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7009 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045111-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.