Strain Name:
C57BL/6J-MtgxR7044Btlr/Mmmh
Stock Number:
045143-MU
Citation ID:
RRID:MMRRC_045143-MU
Other Names:
R7044 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Ptprz, Ptpz, Rptpbeta, RPTPz, DSD-1-PG, PTPbeta, phosphacan, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Ctbp2
Name: C-terminal binding protein 2
Synonyms: Gtrgeo6, D7Ertd45e, Ribeye
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Rpa1
Name: replication protein A1
Synonyms: 5031405K23Rik, Rpa, RP-A, 70kDa, RF-A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68275
Homologene: 2208
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Ube2k
Name: ubiquitin-conjugating enzyme E2K
Synonyms: D5Ertd601e, Hip2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53323
HGNC: HGNC:4914
Homologene: 3903
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: 5830462N02Rik, A130086L21Rik, Hpve6a, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: PipkIII, Pip5k3, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Surf6
Name: surfeit gene 6
Synonyms: Surf-6, D2Wsu129e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20935
Homologene: 133981
Zfp600
Name: zinc finger protein 600
Synonyms: Gm13164
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 667666
Homologene: 133076
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4933435G09Rik, 4930515K21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Pcdh20
Name: protocadherin 20
Synonyms: C630015B17Rik, PCDH13
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219257
Homologene: 11277
Mfge8
Name: milk fat globule EGF and factor V/VIII domain containing
Synonyms: EGF/factor VIII, Mfgm, SED1, MFG-E8, lactadherin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17304
HGNC: HGNC:7036
Homologene: 4334
Pfkp
Name: phosphofructokinase, platelet
Synonyms: 9330125N24Rik, PFK-C, 1200015H23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56421
HGNC: HGNC:8878
Homologene: 20579
Slx9
Name: SLX9 ribosome biogenesis factor
Synonyms: Fam207a, 1810008A18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108707
VEGA: 10
Homologene: 14384
Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms: 2900057D21Rik, 7330406P05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72993
Homologene: 32143
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: B230344L17Rik, Nrbp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Hjv
Name: hemojuvelin BMP co-receptor
Synonyms: HJV, Hfe2, Rgmc, hemojuvelin, 2310035L15Rik, 5230400G09Rik, DL-M
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69585
HGNC: HGNC:4887
Homologene: 17060
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Sybu
Name: syntabulin (syntaxin-interacting)
Synonyms: Golsyn/Syntabulin, 5730410E15Rik, A830027B17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319613
VEGA: 15
Homologene: 9838
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72097
Homologene: 19208
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4921537P18Rik, 4930456F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
Il25
Name: interleukin 25
Synonyms: Il17e, IL-17E
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140806
VEGA: 14
Homologene: 15429
Cdhr2
Name: cadherin-related family member 2
Synonyms: LOC268663, Pcdh24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268663
Homologene: 134510
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Trmt11
Name: tRNA methyltransferase 11
Synonyms: 2410075D05Rik, 3110045I18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73681
VEGA: 10
Homologene: 6876
Or4c100
Name: olfactory receptor family 4 subfamily C member 100
Synonyms: Olfr1186, GA_x6K02T2Q125-50012960-50013871, MOR230-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258523
Homologene: 110555
Tsks
Name: testis-specific serine kinase substrate
Synonyms: Stk22s1, clone 4, Tsks, Tssks1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22116
Homologene: 7984
Otulinl
Name: OTU deubiquitinase with linear linkage specificity like
Synonyms: Fam105a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223433
VEGA: 15
Homologene: 41302
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140577
Homologene: 8967
Glyat
Name: glycine-N-acyltransferase
Synonyms: A330009E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107146
Homologene: 64840
Vmn1r77
Name: vomeronasal 1 receptor 77
Synonyms: Gm6935
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628946
Homologene: 103843
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22341
Homologene: 3962
Krt27
Name: keratin 27
Synonyms: mIRSa3.1, stpm, Krt1-c29
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16675
Homologene: 7805
Fbxl8
Name: F-box and leucine-rich repeat protein 8
Synonyms: FBL8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50788
Homologene: 9279
Trim3
Name: tripartite motif-containing 3
Synonyms: HAC1, BERP1, Rnf22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55992
Homologene: 21290
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: Zfpn1a2, A730095J18Rik, Helios
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22779
Homologene: 22659
Dcdc2c
Name: doublecortin domain containing 2C
Synonyms: 1110015M06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68511
Homologene: 131934
Gm4565
Name: predicted gene 4565
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043638
Homologene: 128656
Gm3543
Name: predicted gene 3543
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,231,410 bp
  • A to T, chromosome 1 at 33,802,167 bp
  • C to T, chromosome 1 at 37,612,280 bp
  • T to C, chromosome 1 at 65,246,854 bp
  • T to C, chromosome 1 at 69,538,901 bp
  • A to G, chromosome 2 at 26,369,953 bp
  • A to G, chromosome 2 at 26,899,356 bp
  • A to G, chromosome 2 at 88,526,486 bp
  • T to C, chromosome 2 at 91,577,601 bp
  • G to C, chromosome 3 at 39,010,810 bp
  • C to T, chromosome 3 at 39,010,811 bp
  • C to A, chromosome 3 at 96,527,474 bp
  • T to A, chromosome 4 at 32,815,260 bp
  • C to T, chromosome 4 at 146,195,322 bp
  • T to C, chromosome 5 at 31,249,946 bp
  • T to C, chromosome 5 at 65,581,429 bp
  • G to A, chromosome 6 at 23,044,346 bp
  • G to A, chromosome 7 at 12,041,834 bp
  • T to A, chromosome 7 at 22,583,370 bp
  • C to T, chromosome 7 at 44,943,792 bp
  • T to C, chromosome 7 at 59,288,413 bp
  • A to G, chromosome 7 at 79,142,520 bp
  • A to T, chromosome 7 at 105,618,214 bp
  • T to C, chromosome 7 at 133,015,102 bp
  • T to C, chromosome 8 at 27,449,895 bp
  • A to G, chromosome 8 at 54,157,045 bp
  • T to A, chromosome 8 at 105,267,015 bp
  • A to G, chromosome 10 at 30,590,934 bp
  • T to C, chromosome 10 at 77,514,392 bp
  • T to C, chromosome 11 at 75,312,802 bp
  • T to C, chromosome 11 at 97,349,790 bp
  • T to A, chromosome 11 at 99,346,814 bp
  • T to C, chromosome 12 at 28,470,494 bp
  • A to G, chromosome 13 at 6,581,567 bp
  • A to T, chromosome 13 at 54,733,321 bp
  • A to G, chromosome 14 at 26,928,677 bp
  • T to A, chromosome 14 at 41,980,066 bp
  • G to A, chromosome 14 at 54,933,158 bp
  • A to G, chromosome 14 at 88,469,171 bp
  • A to G, chromosome 15 at 27,657,235 bp
  • A to T, chromosome 15 at 44,677,695 bp
  • T to A, chromosome 17 at 18,914,367 bp
  • T to C, chromosome 19 at 12,650,265 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7044 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045143-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.