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Strain Name:
C57BL/6J-MtgxR7046Btlr/Mmmh
Stock Number:
045144-MU
Citation ID:
RRID:MMRRC_045144-MU
Other Names:
R7046 (G1)
Major Collection:

Strain Information

Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Gsr
Name: glutathione reductase
Synonyms: Gr-1, Gr1, D8Ertd238e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Madcam1
Name: mucosal vascular addressin cell adhesion molecule 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17123
VEGA: 10
HGNC: HGNC:6765
Homologene: 8413
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 37,173,878 bp
  • A to T, chromosome 1 at 53,321,551 bp
  • G to A, chromosome 1 at 72,394,716 bp
  • T to A, chromosome 1 at 162,839,694 bp
  • A to G, chromosome 1 at 180,667,370 bp
  • G to T, chromosome 1 at 181,623,003 bp
  • C to A, chromosome 1 at 183,087,466 bp
  • T to G, chromosome 2 at 24,394,973 bp
  • T to C, chromosome 2 at 25,945,189 bp
  • G to T, chromosome 2 at 28,540,729 bp
  • C to T, chromosome 2 at 34,773,192 bp
  • T to A, chromosome 2 at 36,997,161 bp
  • A to G, chromosome 2 at 77,192,566 bp
  • T to C, chromosome 2 at 104,714,422 bp
  • G to T, chromosome 2 at 156,526,892 bp
  • G to A, chromosome 3 at 29,082,215 bp
  • A to T, chromosome 3 at 129,754,958 bp
  • T to C, chromosome 3 at 144,915,606 bp
  • A to G, chromosome 4 at 143,350,169 bp
  • T to A, chromosome 5 at 4,100,188 bp
  • T to C, chromosome 5 at 72,629,353 bp
  • C to T, chromosome 5 at 117,273,706 bp
  • C to T, chromosome 5 at 139,708,944 bp
  • A to G, chromosome 5 at 150,749,920 bp
  • C to T, chromosome 6 at 32,516,505 bp
  • T to A, chromosome 6 at 48,987,578 bp
  • A to G, chromosome 6 at 88,618,515 bp
  • T to G, chromosome 6 at 89,933,556 bp
  • A to G, chromosome 6 at 92,158,357 bp
  • A to G, chromosome 6 at 113,719,383 bp
  • A to G, chromosome 7 at 26,611,226 bp
  • G to A, chromosome 7 at 39,537,363 bp
  • T to C, chromosome 7 at 44,585,085 bp
  • T to C, chromosome 7 at 46,122,940 bp
  • T to A, chromosome 7 at 141,640,189 bp
  • T to A, chromosome 8 at 21,135,455 bp
  • T to A, chromosome 8 at 33,695,062 bp
  • T to C, chromosome 8 at 35,664,790 bp
  • C to T, chromosome 8 at 79,651,042 bp
  • A to G, chromosome 8 at 106,807,116 bp
  • T to C, chromosome 8 at 129,047,619 bp
  • T to A, chromosome 9 at 4,420,278 bp
  • T to A, chromosome 9 at 54,719,255 bp
  • C to T, chromosome 9 at 108,497,135 bp
  • A to C, chromosome 10 at 60,378,751 bp
  • G to T, chromosome 10 at 79,586,962 bp
  • C to T, chromosome 10 at 79,668,305 bp
  • T to A, chromosome 11 at 4,738,886 bp
  • A to T, chromosome 11 at 73,589,732 bp
  • A to G, chromosome 11 at 120,377,374 bp
  • A to G, chromosome 12 at 38,784,370 bp
  • T to G, chromosome 12 at 119,447,038 bp
  • C to A, chromosome 13 at 12,190,209 bp
  • C to A, chromosome 13 at 67,442,299 bp
  • T to G, chromosome 13 at 74,352,875 bp
  • A to T, chromosome 14 at 27,472,435 bp
  • T to A, chromosome 15 at 19,013,201 bp
  • T to C, chromosome 15 at 27,832,051 bp
  • T to A, chromosome 15 at 92,770,422 bp
  • T to A, chromosome 16 at 49,109,299 bp
  • G to T, chromosome 16 at 89,403,735 bp
  • A to G, chromosome 17 at 21,588,457 bp
  • A to T, chromosome 17 at 38,148,800 bp
  • T to A, chromosome 17 at 79,621,379 bp
  • A to T, chromosome 17 at 83,224,258 bp
  • A to G, chromosome 18 at 59,409,803 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7046 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045144-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.