Strain Name:
C57BL/6J-MtgxR7048Btlr/Mmmh
Stock Number:
045146-MU
Citation ID:
RRID:MMRRC_045146-MU
Other Names:
R7048 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Ptprz, Ptpz, Rptpbeta, RPTPz, DSD-1-PG, PTPbeta, phosphacan, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Sh3gl2
Name: SH3-domain GRB2-like 2
Synonyms: 9530001L19Rik, EEN1, Sh3d2a, endophilin A1, B930049H17Rik, endophilin I, EEN-B1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20404
Homologene: 20652
Ank2
Name: ankyrin 2, brain
Synonyms: Gm4392, Ank-2, ankyrin B, Ankyrin-2, Ankyrin-B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: Wdt4, C130078N17Rik, ANKRD4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Kcmf1
Name: potassium channel modulatory factor 1
Synonyms: 1700094M07Rik, Pmcf, clone DEBT-91
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74287
Homologene: 99845
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Washc2
Name: WASH complex subunit 2
Synonyms: C530005J20Rik, D6Wsu116e, Fam21
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Smc3
Name: structural maintenance of chromosomes 3
Synonyms: SmcD, Mmip1, Cspg6, Bamacan
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13006
HGNC: HGNC:2468
Homologene: 3974
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lec1, Lphn2, Lphh1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, 4833432B22Rik, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: A430089E03Rik, nmf164, lcsd, D18Ertd723e, C85354, D18Ertd139e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Lrrtm1
Name: leucine rich repeat transmembrane neuronal 1
Synonyms: 4632401D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74342
Homologene: 41763
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: D1Pas1-rs1, Dby, 8030469F12Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: SRrp53, 1200013F24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66880
Homologene: 41147
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217351
Homologene: 23137
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Atg4a-ps
Name: autophagy related 4A, pseudogene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102926
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59012
Homologene: 22904
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: D030002L11Rik, LOC382100, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Cyp2r1
Name: cytochrome P450, family 2, subfamily r, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244209
Homologene: 75210
Bbs5
Name: Bardet-Biedl syndrome 5
Synonyms: 1700049I01Rik, 2700023J09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72569
HGNC: HGNC:970
Homologene: 12471
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: NMF355, nmf355, SMCC1, Clc-1, Clc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232875
Homologene: 122136
Taar1
Name: trace amine-associated receptor 1
Synonyms: Tar1, Trar1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1alpha, RIM1a, C030033M19Rik, RIM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: Jhdm1d, Kdm7a, A630082K20Rik, ENSMUSG00000073143
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Ifit1bl2
Name: interferon induced protein with tetratricopeptide repeats 1B like 2
Synonyms: 2010002M12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 112419
Homologene: 78213
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Wbp7, 2610014H22Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: CtIP, 9930104E21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: 1200014I03Rik, Factor XIIIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Pcid2
Name: PCI domain containing 2
Synonyms: A730042J05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234069
Homologene: 10168
Mest
Name: mesoderm specific transcript
Synonyms: Peg1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17294
HGNC: HGNC:7028
Homologene: 1800
Fhl2
Name: four and a half LIM domains 2
Synonyms: SLIM3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14200
HGNC: HGNC:3703
Homologene: 20372
Or14j2
Name: olfactory receptor family 14 subfamily J member 2
Synonyms: GA_x6K02T2PSCP-2034880-2033942, MOR218-9, Olfr113
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258286
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54526
Homologene: 10303
Pramel15
Name: PRAME like 15
Synonyms: Pramef20, Gm13125, EG627009
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627009
Homologene: 133194
Ugt1a8
Name: UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms: OTTMUSG00000020811, A116
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 613123
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC385766, RIM-BP3, LOC239731
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Ano3
Name: anoctamin 3
Synonyms: Tmem16c, B230324K02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Ap1m1
Name: adaptor-related protein complex AP-1, mu subunit 1
Synonyms: [m]1A, mu1A, Cltnm, Adtm1A, AP47
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11767
Homologene: 4017
Tfpi2
Name: tissue factor pathway inhibitor 2
Synonyms: PP5/TFPI-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21789
Homologene: 38194
Thoc5
Name: THO complex 5
Synonyms: Fmip, 1700060C24Rik, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
B3gnt7
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms: beta-3GnT7, C330001H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227327
Homologene: 17049
Phactr2
Name: phosphatase and actin regulator 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215789
Homologene: 8816
Vstm2b
Name: V-set and transmembrane domain containing 2B
Synonyms: 2900093B09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58188
Homologene: 10970
Cdk14
Name: cyclin dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Gpsm2
Name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms: 6230410J09Rik, LGN, Pins
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76123
Homologene: 56584
Trhr2
Name: thyrotropin releasing hormone receptor 2
Synonyms: TRH-R2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170732
Homologene: 44052
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: NADPH oxidase subunit (67kDa), p67phox, NOXA2, Ncf-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65257
Homologene: 9391
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74075
Homologene: 77044
Selenon
Name: selenoprotein N
Synonyms: 1110019I12Rik, Sepn1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74777
Homologene: 10723
Mettl25b
Name: methyltransferase like 25B
Synonyms: Rrnad1, BC023814
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229503
Homologene: 9332
Gm826
Name: predicted gene 826
Synonyms: LOC329554, Gm46773
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329554
Dusp23
Name: dual specificity phosphatase 23
Synonyms: 1300005N15Rik, Ldp-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68440
Homologene: 32368
Cd37
Name: CD37 antigen
Synonyms: Tspan26
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12493
HGNC: HGNC:1666
Homologene: 20422
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 22,472,820 bp
  • A to G, chromosome 1 at 43,123,648 bp
  • T to C, chromosome 1 at 86,305,586 bp
  • T to C, chromosome 1 at 88,088,302 bp
  • T to C, chromosome 1 at 150,599,653 bp
  • A to C, chromosome 1 at 152,808,170 bp
  • A to T, chromosome 1 at 172,631,686 bp
  • A to G, chromosome 2 at 12,111,084 bp
  • T to C, chromosome 2 at 69,654,361 bp
  • A to T, chromosome 2 at 110,682,771 bp
  • C to T, chromosome 2 at 158,757,254 bp
  • C to T, chromosome 2 at 160,327,106 bp
  • A to G, chromosome 3 at 67,180,831 bp
  • A to G, chromosome 3 at 87,929,860 bp
  • A to G, chromosome 3 at 103,645,356 bp
  • C to T, chromosome 3 at 108,703,045 bp
  • T to A, chromosome 3 at 127,025,618 bp
  • T to C, chromosome 3 at 148,846,929 bp
  • A to G, chromosome 4 at 32,767,969 bp
  • G to A, chromosome 4 at 41,196,033 bp
  • T to A, chromosome 4 at 85,377,565 bp
  • T to C, chromosome 4 at 134,542,843 bp
  • T to C, chromosome 4 at 144,377,184 bp
  • T to A, chromosome 5 at 5,093,005 bp
  • C to A, chromosome 6 at 3,968,032 bp
  • G to A, chromosome 6 at 22,119,470 bp
  • A to T, chromosome 6 at 22,961,623 bp
  • T to G, chromosome 6 at 30,742,724 bp
  • T to C, chromosome 6 at 39,169,048 bp
  • T to C, chromosome 6 at 42,307,543 bp
  • C to T, chromosome 6 at 72,849,467 bp
  • A to G, chromosome 6 at 77,244,169 bp
  • T to C, chromosome 6 at 116,220,583 bp
  • A to T, chromosome 7 at 12,774,744 bp
  • C to T, chromosome 7 at 30,569,306 bp
  • C to T, chromosome 7 at 40,929,376 bp
  • T to C, chromosome 7 at 45,238,464 bp
  • A to T, chromosome 7 at 114,552,736 bp
  • T to C, chromosome 7 at 116,148,324 bp
  • C to T, chromosome 7 at 140,779,368 bp
  • A to G, chromosome 8 at 13,078,243 bp
  • A to G, chromosome 8 at 72,249,798 bp
  • C to T, chromosome 8 at 122,358,679 bp
  • A to T, chromosome 9 at 97,363,421 bp
  • C to T, chromosome 9 at 104,203,414 bp
  • A to T, chromosome 9 at 119,143,404 bp
  • T to A, chromosome 10 at 13,245,424 bp
  • T to C, chromosome 10 at 23,920,824 bp
  • C to A, chromosome 10 at 24,281,476 bp
  • C to A, chromosome 10 at 79,194,319 bp
  • G to A, chromosome 11 at 4,926,237 bp
  • T to A, chromosome 11 at 31,101,121 bp
  • T to G, chromosome 11 at 72,866,699 bp
  • T to A, chromosome 11 at 117,721,974 bp
  • T to C, chromosome 11 at 118,046,118 bp
  • A to G, chromosome 13 at 36,898,143 bp
  • A to G, chromosome 13 at 102,704,923 bp
  • T to A, chromosome 14 at 78,512,514 bp
  • A to C, chromosome 15 at 89,790,805 bp
  • A to G, chromosome 15 at 102,093,136 bp
  • A to G, chromosome 16 at 17,210,326 bp
  • A to T, chromosome 17 at 37,575,223 bp
  • A to G, chromosome 18 at 11,732,220 bp
  • A to G, chromosome 18 at 12,204,765 bp
  • T to C, chromosome 19 at 34,619,151 bp
  • T to C, chromosome 19 at 53,629,251 bp
  • A to T, chromosome Y at 1,279,491 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045146-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.