Strain Name:
C57BL/6J-MtgxR7052Btlr/Mmmh
Stock Number:
045149-MU
Citation ID:
RRID:MMRRC_045149-MU
Other Names:
R7052 (G1)
Major Collection:

Strain Information

Pou2f1
Name: POU domain, class 2, transcription factor 1
Synonyms: oct-1, Oct-1A, Otf-1, Oct-1C, 2810482H01Rik, Oct-1z, Oct1, Oct-1B, Otf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18986
HGNC: HGNC:9212
Homologene: 37658
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Scg3
Name: secretogranin III
Synonyms: 1B1075, SgIII, Chgd
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20255
VEGA: 9
Homologene: 7526
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Inadl, Cipp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Kif11
Name: kinesin family member 11
Synonyms: Kifl1, Eg5, Knsl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Dctn1
Name: dynactin 1
Synonyms: Glued, p150glued, p150
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13191
HGNC: HGNC:2711
Homologene: 3011
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Ero1a
Name: endoplasmic reticulum oxidoreductase 1 alpha
Synonyms: Ero1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50527
VEGA: 14
Homologene: 49392
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, Inoc1, 4632409L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
Riok1
Name: RIO kinase 1
Synonyms: 5430416A05Rik, 3110046C13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71340
VEGA: 13
Homologene: 6950
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Pax1
Name: paired box 1
Synonyms: wt, hbs, hunchback, wavy tail, Pax-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Irf8
Name: interferon regulatory factor 8
Synonyms: IRF-8, Myls, ICSBP, Icsbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Siglec15
Name: sialic acid binding Ig-like lectin 15
Synonyms: Cd33l3, EG620235
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 620235
Homologene: 52643
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20850
Homologene: 20680
Trp73
Name: transformation related protein 73
Synonyms: deltaNp73, TAp73, p73
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22062
Homologene: 3960
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: TRPP5, Polycystin - L2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Mlkl
Name: mixed lineage kinase domain-like
Synonyms: 9130019I15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74568
Homologene: 77416
Pramel1
Name: PRAME like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83491
Homologene: 87078
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: LON, Prss15, 1200017E13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Oog3
Name: oogenesin 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100012
Homologene: 129883
Asb8
Name: ankyrin repeat and SOCS box-containing 8
Synonyms: C430011H06Rik, 4930539L19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78541
Homologene: 32572
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 270893
Homologene: 41524
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V1rd4, V3R4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81014
Homologene: 41799
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Ighg2c
Name: immunoglobulin heavy constant gamma 2C
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 404711
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2A, Sur2, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Pigs
Name: phosphatidylinositol glycan anchor biosynthesis, class S
Synonyms: LOC276846, LOC245087
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276846
Homologene: 41963
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: 0610005A07Rik, Cd203c
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114301
Homologene: 9804
Fut1
Name: fucosyltransferase 1
Synonyms: H transferase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14343
HGNC: HGNC:4012
Homologene: 120
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, 4732433M03Rik, CPSase I, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Als2cl
Name: ALS2 C-terminal like
Synonyms: D930044G19Rik, mRn.49018
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235633
Homologene: 17152
Fam209
Name: family with sequence similarity 209
Synonyms: 1700029J11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76426
Homologene: 19218
Zfp27
Name: zinc finger protein 27
Synonyms: Zfp-27, mkr-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22689
Homologene: 81823
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: 1700056N23Rik, 1700042F02Rik, SAPLT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67331
VEGA: 10
Homologene: 19034
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Or5b123
Name: olfactory receptor family 5 subfamily B member 123
Synonyms: GA_x6K02T2RE5P-3951719-3952666, MOR202-18, Olfr1487
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258629
Homologene: 110492
Coro6
Name: coronin 6
Synonyms: clipin E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216961
Homologene: 104099
Pih1d2
Name: PIH1 domain containing 2
Synonyms: 2700059L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72614
Homologene: 12474
Vmn1r9
Name: vomeronasal 1 receptor 9
Synonyms: V1rc30
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171203
Homologene: 76459
Snx20
Name: sorting nexin 20
Synonyms: 9130017C17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71607
Homologene: 12399
Garin2
Name: golgi associated RAB2 interactor 2
Synonyms: 4921509E07Rik, Fam71d, 4930516C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70897
Homologene: 49887
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72960
Homologene: 43082
Semg1
Name: semenogelin 1
Synonyms: SVS II, semenoclotin, Svs2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53878
Homologene: 49325
Capn15
Name: calpain 15
Synonyms: Solh
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50817
Homologene: 45782
Or6c38
Name: olfactory receptor family 6 subfamily C member 38
Synonyms: MOR114-4, GA_x6K02T2PULF-10779441-10778503, Olfr768
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258863
Homologene: 17159
Bves
Name: blood vessel epicardial substance
Synonyms: Popdc1, popeye 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23828
VEGA: 10
HGNC: HGNC:1152
Homologene: 48497
Fam89b
Name: family with sequence similarity 89, member B
Synonyms: Mtvr2, Fam89b, 1110021A21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17826
Homologene: 18749
H2-Aa
Name: histocompatibility 2, class II antigen A, alpha
Synonyms: I-Aalpha, Ia-1, Aalpha, H-2Aa, A alpha, Ia1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14960
Homologene: 123820
Spi1
Name: Spi-1 proto-oncogene
Synonyms: PU.1, Dis-1, Spi-1, Tcfpu1, Sfpi-1, spleen focus forming virus (SFFV) proviral integration oncogene, Tfpu.1, Sfpi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20375
Homologene: 2346
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: Armc11, 4921528O07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78258
Homologene: 123521
Trav6d-4
Name: T cell receptor alpha variable 6D-4
Synonyms: LOC193570, LOC277146
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277146
Gm47985
Name: predicted gene, 47985
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 44,057,306 bp
  • T to A, chromosome 1 at 67,198,410 bp
  • A to G, chromosome 1 at 140,383,047 bp
  • T to A, chromosome 1 at 151,183,139 bp
  • T to A, chromosome 1 at 163,038,956 bp
  • C to T, chromosome 1 at 165,915,115 bp
  • T to A, chromosome 2 at 91,113,340 bp
  • A to G, chromosome 2 at 119,426,587 bp
  • G to A, chromosome 2 at 147,365,904 bp
  • G to C, chromosome 2 at 155,614,133 bp
  • A to G, chromosome 2 at 164,238,206 bp
  • G to A, chromosome 2 at 172,472,831 bp
  • T to A, chromosome 3 at 107,931,317 bp
  • T to C, chromosome 3 at 116,923,363 bp
  • A to G, chromosome 4 at 98,677,260 bp
  • T to C, chromosome 4 at 143,396,504 bp
  • A to T, chromosome 4 at 144,160,457 bp
  • C to A, chromosome 4 at 145,163,344 bp
  • A to T, chromosome 4 at 154,064,683 bp
  • T to C, chromosome 5 at 108,161,688 bp
  • A to G, chromosome 6 at 35,215,142 bp
  • T to C, chromosome 6 at 57,071,411 bp
  • T to A, chromosome 6 at 83,195,280 bp
  • C to T, chromosome 6 at 142,658,535 bp
  • A to G, chromosome 7 at 5,411,135 bp
  • AATCCGCTTGTGCA to AA, chromosome 7 at 29,895,021 bp
  • A to G, chromosome 7 at 45,619,757 bp
  • T to C, chromosome 8 at 40,555,833 bp
  • T to C, chromosome 8 at 88,629,978 bp
  • G to A, chromosome 8 at 111,319,442 bp
  • C to T, chromosome 8 at 120,739,842 bp
  • A to G, chromosome 9 at 50,621,777 bp
  • C to A, chromosome 9 at 75,661,382 bp
  • C to T, chromosome 9 at 110,898,083 bp
  • G to A, chromosome 10 at 45,346,290 bp
  • C to T, chromosome 10 at 80,520,024 bp
  • T to C, chromosome 10 at 129,093,875 bp
  • C to A, chromosome 11 at 77,466,230 bp
  • C to T, chromosome 11 at 78,341,385 bp
  • T to C, chromosome 11 at 82,437,363 bp
  • T to C, chromosome 11 at 100,879,285 bp
  • C to T, chromosome 12 at 78,719,402 bp
  • T to C, chromosome 12 at 113,288,723 bp
  • C to T, chromosome 13 at 38,037,015 bp
  • A to T, chromosome 13 at 46,687,473 bp
  • A to G, chromosome 13 at 100,222,347 bp
  • T to A, chromosome 14 at 45,306,583 bp
  • G to A, chromosome 14 at 52,753,596 bp
  • A to T, chromosome 15 at 4,733,695 bp
  • T to C, chromosome 15 at 75,668,711 bp
  • T to C, chromosome 15 at 98,136,401 bp
  • C to T, chromosome 17 at 19,531,294 bp
  • T to A, chromosome 17 at 22,602,526 bp
  • A to T, chromosome 17 at 25,961,750 bp
  • T to A, chromosome 17 at 34,284,510 bp
  • A to T, chromosome 17 at 56,626,549 bp
  • T to A, chromosome 18 at 34,425,159 bp
  • A to G, chromosome 18 at 37,266,529 bp
  • T to C, chromosome 18 at 78,048,731 bp
  • G to A, chromosome 19 at 5,729,248 bp
  • T to A, chromosome 19 at 13,619,626 bp
  • T to A, chromosome 19 at 37,384,592 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7052 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045149-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.