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Strain Name:
C57BL/6J-MtgxR7069Btlr/Mmmh
Stock Number:
045165-MU
Citation ID:
RRID:MMRRC_045165-MU
Other Names:
R7069 (G1)
Major Collection:

Strain Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Col2a-1, Col2a, Col2, M100856, Rgsc856, Lpk, M100413, Rgsc413
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: InsP6, 1200016D08Rik, Ihpk1, InsP6k1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27399
Homologene: 56602
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16396
Homologene: 88442
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 37,631,901 bp
  • A to T, chromosome 1 at 93,940,619 bp
  • A to T, chromosome 1 at 181,828,789 bp
  • C to A, chromosome 1 at 194,793,904 bp
  • A to T, chromosome 2 at 65,764,606 bp
  • T to C, chromosome 2 at 74,669,024 bp
  • G to A, chromosome 2 at 84,715,011 bp
  • T to C, chromosome 2 at 89,656,566 bp
  • T to C, chromosome 2 at 109,295,002 bp
  • T to A, chromosome 2 at 154,859,744 bp
  • T to G, chromosome 2 at 155,209,994 bp
  • T to A, chromosome 2 at 180,974,120 bp
  • A to G, chromosome 3 at 26,927,334 bp
  • T to A, chromosome 3 at 89,954,571 bp
  • C to T, chromosome 3 at 94,372,907 bp
  • T to C, chromosome 3 at 126,946,298 bp
  • T to A, chromosome 3 at 138,451,051 bp
  • A to T, chromosome 3 at 159,934,329 bp
  • C to T, chromosome 4 at 133,251,712 bp
  • A to T, chromosome 5 at 25,949,844 bp
  • A to G, chromosome 5 at 57,719,784 bp
  • T to A, chromosome 5 at 76,876,356 bp
  • A to G, chromosome 5 at 110,668,124 bp
  • A to C, chromosome 5 at 146,583,539 bp
  • A to T, chromosome 6 at 41,675,960 bp
  • A to C, chromosome 6 at 49,378,498 bp
  • C to A, chromosome 6 at 83,520,763 bp
  • T to G, chromosome 7 at 3,611,239 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • T to C, chromosome 7 at 24,229,360 bp
  • G to A, chromosome 7 at 44,732,374 bp
  • A to G, chromosome 7 at 75,610,262 bp
  • C to A, chromosome 7 at 102,484,772 bp
  • A to T, chromosome 7 at 103,639,960 bp
  • T to C, chromosome 7 at 120,677,832 bp
  • G to A, chromosome 7 at 140,143,744 bp
  • G to A, chromosome 8 at 33,570,720 bp
  • A to C, chromosome 8 at 69,140,745 bp
  • A to C, chromosome 8 at 71,710,497 bp
  • T to A, chromosome 9 at 42,394,941 bp
  • T to C, chromosome 9 at 46,210,743 bp
  • T to C, chromosome 9 at 86,550,169 bp
  • T to C, chromosome 9 at 105,396,707 bp
  • T to A, chromosome 9 at 108,045,452 bp
  • T to C, chromosome 9 at 111,572,326 bp
  • T to C, chromosome 9 at 121,258,810 bp
  • T to C, chromosome 9 at 121,266,517 bp
  • G to T, chromosome 10 at 43,021,440 bp
  • A to G, chromosome 10 at 75,412,768 bp
  • G to A, chromosome 10 at 82,289,943 bp
  • C to A, chromosome 10 at 85,387,656 bp
  • A to T, chromosome 10 at 120,220,759 bp
  • T to C, chromosome 10 at 128,560,690 bp
  • T to A, chromosome 11 at 34,402,677 bp
  • A to C, chromosome 11 at 73,116,143 bp
  • T to C, chromosome 11 at 86,797,743 bp
  • C to A, chromosome 11 at 106,376,259 bp
  • T to C, chromosome 11 at 118,393,173 bp
  • C to A, chromosome 12 at 31,450,935 bp
  • T to A, chromosome 12 at 34,429,549 bp
  • C to T, chromosome 12 at 55,599,836 bp
  • T to C, chromosome 12 at 66,486,752 bp
  • A to G, chromosome 12 at 82,341,406 bp
  • A to G, chromosome 12 at 116,424,717 bp
  • G to A, chromosome 13 at 13,508,768 bp
  • G to A, chromosome 13 at 27,511,467 bp
  • A to T, chromosome 13 at 43,419,622 bp
  • T to C, chromosome 13 at 49,461,743 bp
  • G to A, chromosome 13 at 73,628,410 bp
  • A to T, chromosome 13 at 114,968,240 bp
  • T to A, chromosome 14 at 28,969,303 bp
  • T to C, chromosome 14 at 53,294,799 bp
  • T to C, chromosome 14 at 61,212,496 bp
  • A to T, chromosome 14 at 77,611,324 bp
  • T to A, chromosome 15 at 3,320,484 bp
  • C to T, chromosome 15 at 97,998,588 bp
  • T to A, chromosome 15 at 101,460,728 bp
  • T to A, chromosome 16 at 4,679,611 bp
  • C to A, chromosome 16 at 5,013,498 bp
  • T to A, chromosome 16 at 11,222,661 bp
  • T to A, chromosome 16 at 14,218,939 bp
  • C to G, chromosome 16 at 20,107,481 bp
  • T to A, chromosome 16 at 20,739,433 bp
  • T to C, chromosome 16 at 23,452,455 bp
  • A to T, chromosome 17 at 7,769,735 bp
  • A to T, chromosome 17 at 35,440,031 bp
  • A to T, chromosome 17 at 94,733,633 bp
  • A to G, chromosome 18 at 36,787,956 bp
  • A to T, chromosome 19 at 28,531,519 bp
  • G to A, chromosome 19 at 38,758,940 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7069 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045165-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.