Strain Name:
C57BL/6J-MtgxR7076Btlr/Mmmh
Stock Number:
045171-MU
Citation ID:
RRID:MMRRC_045171-MU
Other Names:
R7076 (G1)
Major Collection:

Strain Information

Ppp2r2d
Name: protein phosphatase 2, regulatory subunit B, delta
Synonyms: 1300017E19Rik, MDS026, D7Ertd753e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52432
Homologene: 81915
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Neurog3
Name: neurogenin 3
Synonyms: ngn3, Atoh5, bHLHa7, Math4B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11925
VEGA: 10
Homologene: 40692
Gpm6a
Name: glycoprotein m6a
Synonyms: M6A, Gpm6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50765
Homologene: 2428
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, LOC381139, 6430585N13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Pcp-1, Ip3r, Itpr-1, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Arrdc3
Name: arrestin domain containing 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105171
Homologene: 69318
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Tulip1, Garnl1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: CP110, 6330503K22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101565
Homologene: 8810
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: mGluR7, Gpr1g, E130018M02Rik, 6330570A01Rik, mGlu7a receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Zfp68
Name: zinc finger protein 68
Synonyms: KRAZ2, Zfp68, KRAB3, Zfp70
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24135
Homologene: 56605
Znrf2
Name: zinc and ring finger 2
Synonyms: 1190002C14Rik, D6Ertd365e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387524
Homologene: 15668
Zfp524
Name: zinc finger protein 524
Synonyms: 0610012F07Rik, 2300009P13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66056
Homologene: 11912
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: TEC, NOR-1, Nor1, MINOR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
Synonyms: D530030H10Rik, 2310051N18Rik, 2410044A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71941
Homologene: 11575
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Prss32
Name: serine protease 32
Synonyms: 2010001P08Rik, mT5, tryptase-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69814
Homologene: 84859
Nipsnap3b
Name: nipsnap homolog 3B
Synonyms: 2700063N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66536
Homologene: 75044
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, MOR106-14, Olfr265, Olfr743-ps1, Olfr264, Olfr743
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Usp12
Name: ubiquitin specific peptidase 12
Synonyms: Ubh1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22217
Homologene: 56137
Or2d36
Name: olfactory receptor family 2 subfamily D member 36
Synonyms: GA_x6K02T2PBJ9-9497411-9498355, MOR260-2, Olfr716
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258597
Homologene: 121514
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Or5p63
Name: olfactory receptor family 5 subfamily P member 63
Synonyms: GA_x6K02T2PBJ9-10541702-10540758, MOR204-31P, MOR204-29P, MOR204-31P, Olfr1538-ps1, Olfr487
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258042
Homologene: 110483
Has1
Name: hyaluronan synthase 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15116
VEGA: 17
HGNC: HGNC:4818
Homologene: 1165
F830016B08Rik
Name: RIKEN cDNA F830016B08 gene
Synonyms: Ifgga4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240328
VEGA: 18
Homologene: 129714
Or5b124
Name: olfactory receptor family 5 subfamily B member 124
Synonyms: GA_x6K02T2RE5P-3965668-3966609, MOR202-19, Olfr1489
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258628
Homologene: 45021
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: Obph1, ORP5, 1110006M06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79196
Homologene: 98024
Or5af2
Name: olfactory receptor family 5 subfamily AC member 20
Synonyms: GA_x6K02T2NKPP-590035-589109, MOR222-2, Olfr313
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258529
Homologene: 77375
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Sdr16c5
Name: short chain dehydrogenase/reductase family 16C, member 5
Synonyms: Scdr9, Rdhe2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242285
Homologene: 15039
Or52u1
Name: olfactory receptor family 52 subfamily U member 1
Synonyms: GA_x6K02T2PBJ9-7215221-7216195, MOR38-2, Olfr654
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258377
Homologene: 90859
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Ghdc
Name: GH3 domain containing
Synonyms: D11Lgp1e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80860
Homologene: 32760
Gpr171
Name: G protein-coupled receptor 171
Synonyms: F730001G15Rik, H963
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229323
Homologene: 36330
Tmco5b
Name: transmembrane and coiled-coil domains 5B
Synonyms: 4930563P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75275
Homologene: 52839
Tvp23a
Name: trans-golgi network vesicle protein 23A
Synonyms: Fam18a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 383103
Homologene: 19919
Slc23a4
Name: solute carrier family 23 member 4
Synonyms: LOC243753, 2010107G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243753
Homologene: 134124
Cd164
Name: CD164 antigen
Synonyms: MGC-24, A24, A115
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53599
HGNC: HGNC:1632
Homologene: 38129
Srp14
Name: signal recognition particle 14
Synonyms: 14kDa, (homologous Alu RNA binding protein)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20813
Homologene: 37738
Gm19965
Name: predicted gene, 19965
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 116,821,275 bp
  • C to A, chromosome 2 at 13,306,280 bp
  • T to A, chromosome 2 at 13,306,281 bp
  • A to G, chromosome 2 at 113,287,421 bp
  • T to C, chromosome 2 at 118,479,390 bp
  • T to C, chromosome 2 at 166,633,382 bp
  • G to T, chromosome 3 at 59,098,156 bp
  • T to A, chromosome 3 at 133,467,023 bp
  • A to G, chromosome 4 at 4,006,591 bp
  • G to A, chromosome 4 at 48,055,957 bp
  • T to A, chromosome 4 at 53,021,095 bp
  • T to C, chromosome 5 at 6,769,751 bp
  • A to T, chromosome 5 at 137,583,574 bp
  • A to G, chromosome 5 at 138,606,939 bp
  • A to G, chromosome 5 at 146,737,752 bp
  • A to G, chromosome 6 at 34,956,884 bp
  • T to A, chromosome 6 at 54,842,695 bp
  • A to G, chromosome 6 at 108,388,296 bp
  • A to G, chromosome 6 at 111,358,152 bp
  • A to G, chromosome 7 at 5,017,896 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • A to T, chromosome 7 at 104,588,223 bp
  • A to G, chromosome 7 at 105,761,871 bp
  • T to C, chromosome 7 at 107,148,029 bp
  • A to T, chromosome 7 at 108,211,998 bp
  • C to A, chromosome 7 at 118,732,405 bp
  • A to G, chromosome 7 at 135,705,629 bp
  • T to C, chromosome 7 at 138,876,597 bp
  • A to G, chromosome 7 at 143,709,840 bp
  • C to T, chromosome 8 at 11,529,649 bp
  • C to T, chromosome 8 at 55,037,451 bp
  • A to G, chromosome 8 at 55,871,659 bp
  • A to T, chromosome 8 at 68,796,751 bp
  • C to T, chromosome 9 at 35,504,150 bp
  • A to G, chromosome 10 at 41,523,197 bp
  • A to G, chromosome 10 at 62,133,580 bp
  • A to G, chromosome 10 at 127,550,183 bp
  • A to T, chromosome 10 at 128,733,583 bp
  • G to A, chromosome 11 at 58,817,164 bp
  • A to G, chromosome 11 at 67,253,173 bp
  • T to C, chromosome 11 at 72,899,559 bp
  • C to A, chromosome 11 at 100,769,714 bp
  • A to T, chromosome 11 at 101,295,324 bp
  • T to C, chromosome 12 at 55,721,576 bp
  • A to T, chromosome 12 at 114,322,782 bp
  • A to T, chromosome 13 at 80,890,696 bp
  • A to G, chromosome 14 at 36,939,829 bp
  • T to A, chromosome 14 at 50,533,821 bp
  • T to C, chromosome 15 at 10,449,631 bp
  • A to G, chromosome 15 at 100,157,972 bp
  • C to T, chromosome 16 at 5,100,119 bp
  • T to C, chromosome 16 at 10,428,735 bp
  • T to C, chromosome 16 at 56,742,406 bp
  • G to A, chromosome 17 at 17,843,806 bp
  • C to T, chromosome 17 at 22,375,156 bp
  • A to G, chromosome 17 at 23,853,921 bp
  • A to T, chromosome 18 at 60,300,471 bp
  • A to T, chromosome 18 at 84,558,476 bp
  • G to T, chromosome 19 at 13,633,880 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7076 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045171-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.