Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7076Btlr/Mmmh
Stock Number:
045171-MU
Citation ID:
RRID:MMRRC_045171-MU
Other Names:
R7076 (G1)
Major Collection:

Strain Information

Ppp2r2d
Name: protein phosphatase 2, regulatory subunit B, delta
Synonyms: 1300017E19Rik, MDS026, D7Ertd753e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52432
Homologene: 81915
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Neurog3
Name: neurogenin 3
Synonyms: ngn3, Atoh5, bHLHa7, Math4B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11925
VEGA: 10
Homologene: 40692
Gpm6a
Name: glycoprotein m6a
Synonyms: M6A, Gpm6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 116,821,275 bp
  • C to A, chromosome 2 at 13,306,280 bp
  • T to A, chromosome 2 at 13,306,281 bp
  • A to G, chromosome 2 at 113,287,421 bp
  • T to C, chromosome 2 at 118,479,390 bp
  • T to C, chromosome 2 at 166,633,382 bp
  • G to T, chromosome 3 at 59,098,156 bp
  • T to A, chromosome 3 at 133,467,023 bp
  • A to G, chromosome 4 at 4,006,591 bp
  • G to A, chromosome 4 at 48,055,957 bp
  • T to A, chromosome 4 at 53,021,095 bp
  • T to C, chromosome 5 at 6,769,751 bp
  • A to T, chromosome 5 at 137,583,574 bp
  • A to G, chromosome 5 at 138,606,939 bp
  • A to G, chromosome 5 at 146,737,752 bp
  • A to G, chromosome 6 at 34,956,884 bp
  • T to A, chromosome 6 at 54,842,695 bp
  • A to G, chromosome 6 at 108,388,296 bp
  • A to G, chromosome 6 at 111,358,152 bp
  • A to G, chromosome 7 at 5,017,896 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • A to T, chromosome 7 at 104,588,223 bp
  • A to G, chromosome 7 at 105,761,871 bp
  • T to C, chromosome 7 at 107,148,029 bp
  • A to T, chromosome 7 at 108,211,998 bp
  • C to A, chromosome 7 at 118,732,405 bp
  • A to G, chromosome 7 at 135,705,629 bp
  • T to C, chromosome 7 at 138,876,597 bp
  • A to G, chromosome 7 at 143,709,840 bp
  • C to T, chromosome 8 at 11,529,649 bp
  • C to T, chromosome 8 at 55,037,451 bp
  • A to G, chromosome 8 at 55,871,659 bp
  • A to T, chromosome 8 at 68,796,751 bp
  • C to T, chromosome 9 at 35,504,150 bp
  • A to G, chromosome 10 at 41,523,197 bp
  • A to G, chromosome 10 at 62,133,580 bp
  • A to G, chromosome 10 at 127,550,183 bp
  • A to T, chromosome 10 at 128,733,583 bp
  • G to A, chromosome 11 at 58,817,164 bp
  • A to G, chromosome 11 at 67,253,173 bp
  • T to C, chromosome 11 at 72,899,559 bp
  • C to A, chromosome 11 at 100,769,714 bp
  • A to T, chromosome 11 at 101,295,324 bp
  • T to C, chromosome 12 at 55,721,576 bp
  • A to T, chromosome 12 at 114,322,782 bp
  • A to T, chromosome 13 at 80,890,696 bp
  • A to G, chromosome 14 at 36,939,829 bp
  • T to A, chromosome 14 at 50,533,821 bp
  • T to C, chromosome 15 at 10,449,631 bp
  • A to G, chromosome 15 at 100,157,972 bp
  • C to T, chromosome 16 at 5,100,119 bp
  • T to C, chromosome 16 at 10,428,735 bp
  • T to C, chromosome 16 at 56,742,406 bp
  • G to A, chromosome 17 at 17,843,806 bp
  • C to T, chromosome 17 at 22,375,156 bp
  • A to G, chromosome 17 at 23,853,921 bp
  • A to T, chromosome 18 at 60,300,471 bp
  • A to T, chromosome 18 at 84,558,476 bp
  • G to T, chromosome 19 at 13,633,880 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7076 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045171-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.