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Strain Name:
C57BL/6J-MtgxR7080Btlr/Mmmh
Stock Number:
045174-MU
Citation ID:
RRID:MMRRC_045174-MU
Other Names:
R7080 (G1)
Major Collection:

Strain Information

Atox1
Name: antioxidant 1 copper chaperone
Synonyms: ATX1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11927
HGNC: HGNC:798
Homologene: 2984
Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Steel Factor Receptor, c-KIT, Dominant white spotting, belly-spot, Tr-kit, SOW3, SCO5, SCO1, Gsfsow3, Gsfsco5, Gsfsco1, CD117
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Ranbp1
Name: RAN binding protein 1
Synonyms: Htf9a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19385
HGNC: HGNC:9847
Homologene: 21600
Gpr19
Name: G protein-coupled receptor 19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14760
HGNC: HGNC:4473
Homologene: 4476
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Atp6v1e1
Name: ATPase, H+ transporting, lysosomal V1 subunit E1
Synonyms: H(+)-ATPase E-like protein, H+ ATPase subunit E, Atp6e2, Atp6e, E2, 2410029D23Rik, Atp6v1e, lysosomal 31kDa, D6Ertd385e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11973
HGNC: HGNC:857
Homologene: 1282
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 2410018I08Rik, 1190009E20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69727
Homologene: 56957
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,867,683 bp
  • A to T, chromosome 1 at 66,646,521 bp
  • A to G, chromosome 2 at 25,446,104 bp
  • G to A, chromosome 2 at 34,898,712 bp
  • A to T, chromosome 2 at 86,455,491 bp
  • A to G, chromosome 2 at 87,071,739 bp
  • A to C, chromosome 3 at 30,634,556 bp
  • C to T, chromosome 3 at 36,180,049 bp
  • G to C, chromosome 3 at 154,593,789 bp
  • C to T, chromosome 4 at 43,171,926 bp
  • C to T, chromosome 4 at 116,992,641 bp
  • C to T, chromosome 5 at 24,526,300 bp
  • G to T, chromosome 5 at 74,016,683 bp
  • T to C, chromosome 5 at 75,607,281 bp
  • C to T, chromosome 5 at 99,976,533 bp
  • A to G, chromosome 6 at 71,780,765 bp
  • A to T, chromosome 6 at 116,582,353 bp
  • G to A, chromosome 6 at 120,822,389 bp
  • A to T, chromosome 6 at 134,870,456 bp
  • T to C, chromosome 7 at 6,677,306 bp
  • T to C, chromosome 7 at 28,796,676 bp
  • A to T, chromosome 7 at 102,534,965 bp
  • T to C, chromosome 8 at 119,582,596 bp
  • A to G, chromosome 9 at 39,950,148 bp
  • A to G, chromosome 9 at 104,099,562 bp
  • A to G, chromosome 9 at 107,901,786 bp
  • T to C, chromosome 10 at 22,665,317 bp
  • T to A, chromosome 11 at 55,450,539 bp
  • C to T, chromosome 11 at 80,674,634 bp
  • T to C, chromosome 11 at 86,506,840 bp
  • G to T, chromosome 11 at 96,856,712 bp
  • G to A, chromosome 11 at 107,180,052 bp
  • A to G, chromosome 12 at 11,456,365 bp
  • G to A, chromosome 12 at 76,052,727 bp
  • G to A, chromosome 13 at 62,370,295 bp
  • T to C, chromosome 13 at 119,949,734 bp
  • T to C, chromosome 14 at 34,692,356 bp
  • T to C, chromosome 14 at 54,857,655 bp
  • T to C, chromosome 14 at 67,698,102 bp
  • G to A, chromosome 15 at 85,932,451 bp
  • T to C, chromosome 15 at 89,133,147 bp
  • T to C, chromosome 15 at 102,118,192 bp
  • T to C, chromosome 16 at 18,245,233 bp
  • T to C, chromosome 16 at 96,009,530 bp
  • C to T, chromosome 17 at 23,673,529 bp
  • A to T, chromosome 17 at 89,097,111 bp
  • C to T, chromosome 18 at 37,478,463 bp
  • T to A, chromosome 18 at 50,280,673 bp
  • T to C, chromosome 19 at 6,315,189 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045174-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.