Strain Name:
C57BL/6J-MtgxR7080Btlr/Mmmh
Stock Number:
045174-MU
Citation ID:
RRID:MMRRC_045174-MU
Other Names:
R7080 (G1)
Major Collection:

Strain Information

Atox1
Name: antioxidant 1 copper chaperone
Synonyms: ATX1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11927
HGNC: HGNC:798
Homologene: 2984
Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: SOW3, Dominant white spotting, c-KIT, Steel Factor Receptor, CD117, belly-spot, Tr-kit, Gsfsow3, Gsfsco5, SCO1, SCO5, Gsfsco1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Ranbp1
Name: RAN binding protein 1
Synonyms: Htf9a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19385
HGNC: HGNC:9847
Homologene: 21600
Gpr19
Name: G protein-coupled receptor 19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14760
HGNC: HGNC:4473
Homologene: 4476
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: S6K1, p70S6K1, p70/85s6k, 2610318I15Rik, p70s6k
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Atp6v1e1
Name: ATPase, H+ transporting, lysosomal V1 subunit E1
Synonyms: lysosomal 31kDa, 2410029D23Rik, Atp6e2, H+ ATPase subunit E, D6Ertd385e, H(+)-ATPase E-like protein, Atp6v1e, E2, Atp6e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11973
HGNC: HGNC:857
Homologene: 1282
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 1190009E20Rik, 2410018I08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69727
Homologene: 56957
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, D530019K20Rik, G1-403-16, 5330419I02Rik, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Hnrnpd
Name: heterogeneous nuclear ribonucleoprotein D
Synonyms: Auf1, Hnrpd
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11991
HGNC: HGNC:5036
Homologene: 22410
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Bmpr2
Name: bone morphogenetic protein receptor type 2
Synonyms: BMPR-II, BMPRII, BMP-2, 2610024H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12168
HGNC: HGNC:1078
Homologene: 929
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68979
Homologene: 32264
Mon1a
Name: MON1 homolog A, secretory traffciking associated
Synonyms: 2810468K17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72825
Homologene: 7191
Tyw3
Name: tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
Synonyms: 5230400J09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 209584
Homologene: 44531
Spryd3
Name: SPRY domain containing 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223918
Homologene: 13138
Thoc6
Name: THO complex 6
Synonyms: Wdr58, F830014G06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 386612
Homologene: 11533
Pcdhb16
Name: protocadherin beta 16
Synonyms: Pcdhb8, PcdhbP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93887
Homologene: 99843
Ackr4
Name: atypical chemokine receptor 4
Synonyms: VSHK1, A630091E18Rik, CCR11, Ccrl1, CCBP2, CCX-CKR, PPR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Urod
Name: uroporphyrinogen decarboxylase
Synonyms: Uro-d
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22275
Homologene: 320
Zim1
Name: zinc finger, imprinted 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22776
Homologene: 129793
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Fshr
Name: follicle stimulating hormone receptor
Synonyms: FSH-R, Follitropin receptor, follicle-stimulating hormone receptor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Or6d15
Name: olfactory receptor family 6 subfamily D member 15
Synonyms: GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258438
Homologene: 133693
Phf19
Name: PHD finger protein 19
Synonyms: 3321402G02Rik, 3110009G19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74016
Homologene: 12524
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: Olfr975, GA_x6K02T2PVTD-33651220-33650288, MOR224-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Mapk12
Name: mitogen-activated protein kinase 12
Synonyms: P38gamma, Prkm12, Erk6, Sapk3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29857
VEGA: 15
HGNC: HGNC:6874
Homologene: 55705
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Dnaaf1
Name: dynein, axonemal assembly factor 1
Synonyms: m4Bei, Lrrc50, 4930457P18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68270
Homologene: 12256
Lrrc34
Name: leucine rich repeat containing 34
Synonyms: Spata34, 1700007J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71827
Homologene: 27419
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: AQ27, Gpr103
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229214
Homologene: 18865
Or8k28
Name: olfactory receptor family 8 subfamily K member 28
Synonyms: GA_x6K02T2Q125-47925557-47924616, MOR188-8, MOR256-52P, Olfr1066
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257880
Homologene: 79468
Fam170a
Name: family with sequence similarity 170, member A
Synonyms: Znfd, LOC225497
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225497
VEGA: 18
Homologene: 86702
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: GLUT-12, Glut12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Or5aq1b
Name: olfactory receptor family 5 subfamily AQ member 1B
Synonyms: GA_x6K02T2Q125-48565383-48564445, Olfr1107, MOR172-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258841
Homologene: 131138
Or52b4
Name: olfactory receptor family 52 subfamily B member 4
Synonyms: MOR31-4, Olfr547, GA_x6K02T2PBJ9-5256044-5256988
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259083
Homologene: 17493
Rinl
Name: Ras and Rab interactor-like
Synonyms: 9930116N10Rik, 5830482F20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320435
Homologene: 18556
Homez
Name: homeodomain leucine zipper-encoding gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239099
Homologene: 10828
Reep1
Name: receptor accessory protein 1
Synonyms: D6Ertd253e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52250
Homologene: 41504
Copz2
Name: coatomer protein complex, subunit zeta 2
Synonyms: zeta2-COP, nonclathrin coat protein zeta2-COP, 1110012D12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56358
Homologene: 69215
Gbx1
Name: gastrulation brain homeobox 1
Synonyms: Gbx-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231044
HGNC: HGNC:4185
Homologene: 41063
Tcstv5a
Name: Tcstv family member 5A
Synonyms: B020031M17Rik, Tcstv5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 333467
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,867,683 bp
  • A to T, chromosome 1 at 66,646,521 bp
  • A to G, chromosome 2 at 25,446,104 bp
  • G to A, chromosome 2 at 34,898,712 bp
  • A to T, chromosome 2 at 86,455,491 bp
  • A to G, chromosome 2 at 87,071,739 bp
  • A to C, chromosome 3 at 30,634,556 bp
  • C to T, chromosome 3 at 36,180,049 bp
  • G to C, chromosome 3 at 154,593,789 bp
  • C to T, chromosome 4 at 43,171,926 bp
  • C to T, chromosome 4 at 116,992,641 bp
  • C to T, chromosome 5 at 24,526,300 bp
  • G to T, chromosome 5 at 74,016,683 bp
  • T to C, chromosome 5 at 75,607,281 bp
  • C to T, chromosome 5 at 99,976,533 bp
  • A to G, chromosome 6 at 71,780,765 bp
  • A to T, chromosome 6 at 116,582,353 bp
  • G to A, chromosome 6 at 120,822,389 bp
  • A to T, chromosome 6 at 134,870,456 bp
  • T to C, chromosome 7 at 6,677,306 bp
  • T to C, chromosome 7 at 28,796,676 bp
  • A to T, chromosome 7 at 102,534,965 bp
  • T to C, chromosome 8 at 119,582,596 bp
  • A to G, chromosome 9 at 39,950,148 bp
  • A to G, chromosome 9 at 104,099,562 bp
  • A to G, chromosome 9 at 107,901,786 bp
  • T to C, chromosome 10 at 22,665,317 bp
  • T to A, chromosome 11 at 55,450,539 bp
  • C to T, chromosome 11 at 80,674,634 bp
  • T to C, chromosome 11 at 86,506,840 bp
  • G to T, chromosome 11 at 96,856,712 bp
  • G to A, chromosome 11 at 107,180,052 bp
  • A to G, chromosome 12 at 11,456,365 bp
  • G to A, chromosome 12 at 76,052,727 bp
  • G to A, chromosome 13 at 62,370,295 bp
  • T to C, chromosome 13 at 119,949,734 bp
  • T to C, chromosome 14 at 34,692,356 bp
  • T to C, chromosome 14 at 54,857,655 bp
  • T to C, chromosome 14 at 67,698,102 bp
  • G to A, chromosome 15 at 85,932,451 bp
  • T to C, chromosome 15 at 89,133,147 bp
  • T to C, chromosome 15 at 102,118,192 bp
  • T to C, chromosome 16 at 18,245,233 bp
  • T to C, chromosome 16 at 96,009,530 bp
  • C to T, chromosome 17 at 23,673,529 bp
  • A to T, chromosome 17 at 89,097,111 bp
  • C to T, chromosome 18 at 37,478,463 bp
  • T to A, chromosome 18 at 50,280,673 bp
  • T to C, chromosome 19 at 6,315,189 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045174-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.