Strain Name:
C57BL/6J-MtgxR7089Btlr/Mmmh
Stock Number:
045183-MU
Citation ID:
RRID:MMRRC_045183-MU
Other Names:
R7089 (G1)
Major Collection:

Strain Information

Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Kcmf1
Name: potassium channel modulatory factor 1
Synonyms: clone DEBT-91, 1700094M07Rik, Pmcf
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74287
Homologene: 99845
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Dnmt1
Name: DNA methyltransferase 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224807
Homologene: 101682
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Clcn7
Name: chloride channel, voltage-sensitive 7
Synonyms: ClC-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26373
HGNC: HGNC:2025
Homologene: 56546
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, Afadin, S-afadin, I-afadin, 5033403D15Rik, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, Prp8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192159
Homologene: 4706
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Ints13
Name: integrator complex subunit 13
Synonyms: 4933424B01Rik, Spata30, Asun
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71177
Homologene: 10043
Tbc1d14
Name: TBC1 domain family, member 14
Synonyms: 2810413P16Rik, D5Ertd110e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100855
Homologene: 10809
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, Unc5h2, D10Bwg0792e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217337
Homologene: 7056
Tpm3
Name: tropomyosin 3, gamma
Synonyms: hTMnm, hTM30nm, gamma-TM, skalphaTM.2, Tpm-5, Trop-5, Tpm5, Tm5NM
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59069
Homologene: 81889
Drd3
Name: dopamine receptor D3
Synonyms: D3R, D3 receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13490
VEGA: 16
HGNC: HGNC:3024
Homologene: 623
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: CD140b, Pdgfr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: 2700053F16Rik, Pdir
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72599
VEGA: 16
Homologene: 4957
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227449
Homologene: 9808
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142980
Homologene: 20696
Rerg
Name: RAS-like, estrogen-regulated, growth-inhibitor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232441
Homologene: 50026
Il15
Name: interleukin 15
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16168
HGNC: HGNC:5977
Homologene: 487
Adgrf4
Name: adhesion G protein-coupled receptor F4
Synonyms: 4632435A09Rik, Gpr115
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78249
Homologene: 51953
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Or5ak24
Name: olfactory receptor family 5 subfamily AK member 24
Synonyms: GA_x6K02T2Q125-46907515-46906571, MOR203-4, Olfr994
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258425
Homologene: 17245
Cdt1
Name: chromatin licensing and DNA replication factor 1
Synonyms: 2610318F11Rik, Ris2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67177
Homologene: 32650
1700010I14Rik
Name: RIKEN cDNA 1700010I14 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66931
Homologene: 49841
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: ovalbumin, SPI3B, Gm11396
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Or5p62
Name: olfactory receptor family 5 subfamily P member 62
Synonyms: GA_x6K02T2PBJ9-10501920-10500976, MOR204-19, Olfr486
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258489
Homologene: 110483
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140579
Homologene: 44338
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: Hh1, 9630005B12Rik, 5830411O09Rik, 8430421H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29809
Homologene: 8143
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: mENaC, ENaC alpha, Scnn1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20276
Homologene: 811
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI3Kgamma, p110gamma, PI3Kgamma, PI(3)Kgamma, 5830428L06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Trim28
Name: tripartite motif-containing 28
Synonyms: KRIP-1, KAP-1, Tif1b, MommeD9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21849
Homologene: 21175
Ccdc192
Name: coiled-coil domain containing 192
Synonyms: 1700011I03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75444
Homologene: 133296
Or13d1
Name: olfactory receptor family 13 subfamily D member 1
Synonyms: GA_x6K02T2N78B-7025964-7025020, MOR262-9, Olfr270
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258600
Homologene: 17313
Mpz
Name: myelin protein zero
Synonyms: P0, Mpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17528
HGNC: HGNC:7225
Homologene: 445
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67307
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Endou
Name: endonuclease, polyU-specific
Synonyms: Tcl-30, Pp11r
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19011
VEGA: 15
Homologene: 48394
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: 9930032O22Rik, Desc4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320454
Homologene: 82239
Lgi2
Name: leucine-rich repeat LGI family, member 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246316
Homologene: 10048
Rmnd1
Name: required for meiotic nuclear division 1 homolog
Synonyms: 0610042C05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66084
Homologene: 5675
Fez1
Name: fasciculation and elongation protein zeta 1
Synonyms: UNC-76, UNC76, zygin I
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Ammecr1l
Name: AMME chromosomal region gene 1-like
Synonyms: 5430429D03Rik, E230022H04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225339
VEGA: 18
Homologene: 69488
Arhgap45
Name: Rho GTPase activating protein 45
Synonyms: 6330406L22Rik, Hmha1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70719
Homologene: 69120
Vmn1r236
Name: vomeronasal 1 receptor 236
Synonyms: V1rf4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171235
Rhcg
Name: Rhesus blood group-associated C glycoprotein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56315
Homologene: 32310
Clpp
Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
Synonyms: D17Wsu160e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53895
VEGA: 17
HGNC: HGNC:2084
Homologene: 4385
Speer4f2
Name: spermatogenesis associated glutamate (E)-rich protein 4f2
Synonyms: Gm3535, Gm3495
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041749
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Ifnl3
Name: interferon lambda 3
Synonyms: INF-lambda, IFL-1, Il28, Il28b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338374
Homologene: 77540
Mafk
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
Synonyms: Nfe2u, p18 NF-E2, NF-E2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17135
HGNC: HGNC:6782
Homologene: 1770
Oxgr1
Name: oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms: LOC239283, P2Y15, Gpr80, Gpr99, Cysltr3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239283
VEGA: 14
HGNC: HGNC:4531
Homologene: 25878
Fbxl16
Name: F-box and leucine-rich repeat protein 16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214931
VEGA: 17
Homologene: 17732
Or5g26
Name: olfactory receptor family 5 subfamily G member 26
Synonyms: OR93, 912-93, Olfr4-3, GA_x6K02T2Q125-47143827-47142871, MOR175-1, Olfr154
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27216
Homologene: 104131
Gm14326
Name: predicted gene 14326
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665211
Homologene: 134324
Gm32742
Name: predicted gene, 32742
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635385
Homologene: 132734
Smim45
Name: small integral membrane protein 45
Synonyms: 1500009C09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76505
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,336,649 bp
  • C to A, chromosome 1 at 106,030,481 bp
  • A to T, chromosome 1 at 160,724,172 bp
  • T to C, chromosome 1 at 171,159,635 bp
  • T to A, chromosome 2 at 85,430,558 bp
  • C to T, chromosome 2 at 85,664,174 bp
  • A to T, chromosome 2 at 165,304,929 bp
  • A to T, chromosome 2 at 177,946,671 bp
  • C to T, chromosome 3 at 90,072,722 bp
  • A to G, chromosome 4 at 45,062,230 bp
  • C to T, chromosome 4 at 52,971,470 bp
  • T to C, chromosome 4 at 137,544,366 bp
  • A to C, chromosome 5 at 17,376,663 bp
  • A to C, chromosome 5 at 30,371,568 bp
  • A to T, chromosome 5 at 36,512,540 bp
  • A to G, chromosome 5 at 52,538,490 bp
  • T to C, chromosome 5 at 86,489,291 bp
  • A to G, chromosome 5 at 139,800,121 bp
  • G to A, chromosome 6 at 72,842,946 bp
  • G to T, chromosome 6 at 72,848,306 bp
  • A to G, chromosome 6 at 83,455,024 bp
  • C to A, chromosome 6 at 125,337,807 bp
  • T to C, chromosome 6 at 137,067,035 bp
  • T to C, chromosome 6 at 146,574,718 bp
  • T to A, chromosome 7 at 13,024,906 bp
  • A to G, chromosome 7 at 28,523,858 bp
  • A to G, chromosome 7 at 79,599,468 bp
  • A to T, chromosome 7 at 108,172,494 bp
  • A to T, chromosome 8 at 45,397,773 bp
  • A to T, chromosome 8 at 82,337,575 bp
  • G to A, chromosome 8 at 122,571,980 bp
  • A to G, chromosome 9 at 15,996,918 bp
  • G to T, chromosome 9 at 20,908,489 bp
  • A to T, chromosome 9 at 36,867,703 bp
  • T to A, chromosome 9 at 51,143,246 bp
  • A to T, chromosome 9 at 57,258,758 bp
  • G to T, chromosome 9 at 112,126,446 bp
  • C to T, chromosome 10 at 4,403,873 bp
  • G to A, chromosome 10 at 60,777,486 bp
  • A to G, chromosome 10 at 63,053,912 bp
  • G to A, chromosome 10 at 80,026,347 bp
  • T to G, chromosome 10 at 125,997,124 bp
  • A to G, chromosome 11 at 75,508,548 bp
  • A to G, chromosome 11 at 116,271,907 bp
  • A to G, chromosome 12 at 32,176,846 bp
  • A to C, chromosome 13 at 11,649,776 bp
  • G to A, chromosome 13 at 33,832,715 bp
  • A to G, chromosome 14 at 51,418,643 bp
  • A to G, chromosome 14 at 55,065,772 bp
  • A to G, chromosome 14 at 120,022,202 bp
  • A to C, chromosome 14 at 123,278,349 bp
  • G to A, chromosome 15 at 9,725,171 bp
  • A to T, chromosome 15 at 82,252,573 bp
  • G to A, chromosome 15 at 97,720,245 bp
  • A to T, chromosome 15 at 98,850,272 bp
  • T to A, chromosome 16 at 25,965,809 bp
  • T to C, chromosome 16 at 35,407,679 bp
  • G to T, chromosome 16 at 43,807,378 bp
  • T to C, chromosome 17 at 9,008,095 bp
  • T to G, chromosome 17 at 13,890,812 bp
  • T to A, chromosome 17 at 21,286,942 bp
  • C to T, chromosome 17 at 25,153,693 bp
  • A to G, chromosome 17 at 25,816,729 bp
  • T to G, chromosome 17 at 42,666,533 bp
  • T to C, chromosome 17 at 45,667,783 bp
  • T to G, chromosome 17 at 56,990,421 bp
  • T to C, chromosome 17 at 71,361,960 bp
  • A to T, chromosome 18 at 31,761,824 bp
  • C to T, chromosome 18 at 57,591,987 bp
  • C to T, chromosome 18 at 61,073,243 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7089 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045183-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.