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Strain Name:
C57BL/6J-MtgxR7098Btlr/Mmmh
Stock Number:
045190-MU
Citation ID:
RRID:MMRRC_045190-MU
Other Names:
R7098 (G1)
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Neurod1
Name: neurogenic differentiation 1
Synonyms: BETA2, Neurod, bHLHa3, Nd1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18012
HGNC: HGNC:7762
Homologene: 1871
P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms: P2X7 receptor, P2X7R, P2X(7)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18439
HGNC: HGNC:8537
Homologene: 1925
Abce1
Name: ATP-binding cassette, sub-family E member 1
Synonyms: RNS4l (Eye), Oabp, Rnaseli
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Dhx9
Name: DExH-box helicase 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 6,827,842 bp
  • A to G, chromosome 1 at 24,526,474 bp
  • A to T, chromosome 1 at 45,380,067 bp
  • C to T, chromosome 1 at 97,898,347 bp
  • T to C, chromosome 1 at 138,099,685 bp
  • T to C, chromosome 1 at 153,465,022 bp
  • C to T, chromosome 1 at 186,630,637 bp
  • T to C, chromosome 2 at 4,572,433 bp
  • T to A, chromosome 2 at 10,579,189 bp
  • T to A, chromosome 2 at 25,338,184 bp
  • C to T, chromosome 2 at 28,675,732 bp
  • T to C, chromosome 2 at 79,454,685 bp
  • C to T, chromosome 2 at 127,854,915 bp
  • A to T, chromosome 2 at 153,906,890 bp
  • T to A, chromosome 3 at 84,175,002 bp
  • T to G, chromosome 3 at 99,216,641 bp
  • C to T, chromosome 3 at 116,641,712 bp
  • T to A, chromosome 3 at 158,041,639 bp
  • T to C, chromosome 4 at 34,746,628 bp
  • T to C, chromosome 4 at 59,753,004 bp
  • C to T, chromosome 4 at 62,499,915 bp
  • A to T, chromosome 4 at 119,282,853 bp
  • C to T, chromosome 4 at 131,922,393 bp
  • C to A, chromosome 4 at 137,716,082 bp
  • T to A, chromosome 4 at 140,580,911 bp
  • A to T, chromosome 5 at 35,702,014 bp
  • A to T, chromosome 5 at 43,683,139 bp
  • A to G, chromosome 5 at 62,675,950 bp
  • A to T, chromosome 5 at 66,260,983 bp
  • G to T, chromosome 5 at 89,861,495 bp
  • A to G, chromosome 5 at 122,673,793 bp
  • T to A, chromosome 5 at 138,646,522 bp
  • T to C, chromosome 5 at 142,096,870 bp
  • T to C, chromosome 5 at 143,357,591 bp
  • T to C, chromosome 6 at 5,398,499 bp
  • A to T, chromosome 7 at 13,816,053 bp
  • A to T, chromosome 7 at 18,652,545 bp
  • C to A, chromosome 7 at 45,874,056 bp
  • T to A, chromosome 7 at 64,736,948 bp
  • C to T, chromosome 7 at 90,450,854 bp
  • T to C, chromosome 7 at 139,979,499 bp
  • T to A, chromosome 8 at 70,888,538 bp
  • T to C, chromosome 8 at 75,120,901 bp
  • T to C, chromosome 8 at 79,686,049 bp
  • C to A, chromosome 9 at 7,475,937 bp
  • T to G, chromosome 9 at 21,634,820 bp
  • T to A, chromosome 9 at 37,343,960 bp
  • T to A, chromosome 9 at 108,999,154 bp
  • T to C, chromosome 9 at 110,372,242 bp
  • A to G, chromosome 10 at 76,384,839 bp
  • C to A, chromosome 11 at 30,850,661 bp
  • C to A, chromosome 11 at 67,279,053 bp
  • T to A, chromosome 11 at 71,218,274 bp
  • T to C, chromosome 11 at 88,929,185 bp
  • T to A, chromosome 11 at 101,737,768 bp
  • T to A, chromosome 11 at 103,077,863 bp
  • G to T, chromosome 11 at 116,063,726 bp
  • T to C, chromosome 11 at 117,714,126 bp
  • A to T, chromosome 12 at 55,790,310 bp
  • A to T, chromosome 12 at 69,312,467 bp
  • G to A, chromosome 12 at 78,719,634 bp
  • A to G, chromosome 12 at 85,917,673 bp
  • A to G, chromosome 12 at 86,470,415 bp
  • A to G, chromosome 13 at 40,003,966 bp
  • A to G, chromosome 13 at 54,466,306 bp
  • A to T, chromosome 13 at 92,274,111 bp
  • C to T, chromosome 15 at 39,793,331 bp
  • C to T, chromosome 15 at 76,408,457 bp
  • C to A, chromosome 15 at 82,035,754 bp
  • C to T, chromosome 15 at 89,188,687 bp
  • A to T, chromosome 16 at 32,757,091 bp
  • C to T, chromosome 16 at 49,177,057 bp
  • T to A, chromosome 16 at 88,962,672 bp
  • A to T, chromosome 17 at 19,694,408 bp
  • T to C, chromosome 17 at 28,298,813 bp
  • C to T, chromosome 17 at 35,064,344 bp
  • A to G, chromosome 19 at 17,120,602 bp
  • T to C, chromosome 19 at 40,180,487 bp
  • G to A, chromosome X at 74,306,855 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7098 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045190-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.