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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7099Btlr/Mmmh
Stock Number:
045191-MU
Citation ID:
RRID:MMRRC_045191-MU
Other Names:
R7099 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132

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Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872

Additional Resources
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Google
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Gene Ontology
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Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680

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Gene Ontology
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ClinGen
Lrrfip2
Name: leucine rich repeat (in FLII) interacting protein 2
Synonyms: 5133400F20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71268
HGNC: HGNC:6703
Homologene: 22476

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 72,643,293 bp
  • G to A, chromosome 1 at 157,488,584 bp
  • G to A, chromosome 1 at 167,830,546 bp
  • G to A, chromosome 1 at 169,506,072 bp
  • G to T, chromosome 2 at 38,694,136 bp
  • C to A, chromosome 2 at 82,987,624 bp
  • A to T, chromosome 2 at 111,755,076 bp
  • T to A, chromosome 2 at 121,300,517 bp
  • T to C, chromosome 2 at 127,539,778 bp
  • A to G, chromosome 4 at 90,224,880 bp
  • A to T, chromosome 4 at 109,242,229 bp
  • A to T, chromosome 4 at 150,629,573 bp
  • T to C, chromosome 4 at 150,866,768 bp
  • A to T, chromosome 5 at 6,772,161 bp
  • A to G, chromosome 5 at 75,944,333 bp
  • A to G, chromosome 5 at 87,240,989 bp
  • A to G, chromosome 5 at 92,293,973 bp
  • A to T, chromosome 5 at 125,304,350 bp
  • A to T, chromosome 5 at 143,726,645 bp
  • T to C, chromosome 6 at 40,661,716 bp
  • C to T, chromosome 6 at 42,630,341 bp
  • C to A, chromosome 6 at 59,210,181 bp
  • T to A, chromosome 6 at 116,516,760 bp
  • A to T, chromosome 7 at 7,672,541 bp
  • T to C, chromosome 7 at 11,756,393 bp
  • A to T, chromosome 7 at 25,346,520 bp
  • T to G, chromosome 7 at 31,053,033 bp
  • A to G, chromosome 7 at 63,757,455 bp
  • G to A, chromosome 7 at 99,813,820 bp
  • AGGCGCAGAAACCCTGGC to AGGC, chromosome 7 at 141,634,450 bp
  • A to C, chromosome 8 at 55,871,404 bp
  • A to G, chromosome 8 at 83,254,891 bp
  • G to A, chromosome 9 at 39,426,303 bp
  • A to G, chromosome 9 at 62,881,145 bp
  • G to A, chromosome 9 at 100,944,826 bp
  • G to T, chromosome 9 at 109,770,155 bp
  • A to T, chromosome 9 at 110,645,438 bp
  • A to G, chromosome 9 at 111,173,108 bp
  • T to C, chromosome 10 at 5,123,744 bp
  • T to C, chromosome 10 at 68,098,179 bp
  • T to C, chromosome 10 at 93,850,187 bp
  • T to C, chromosome 10 at 109,703,334 bp
  • T to A, chromosome 11 at 12,296,540 bp
  • A to G, chromosome 11 at 60,720,655 bp
  • T to C, chromosome 11 at 72,872,649 bp
  • T to C, chromosome 11 at 73,340,399 bp
  • T to C, chromosome 11 at 79,570,330 bp
  • T to C, chromosome 11 at 100,492,291 bp
  • T to C, chromosome 11 at 113,834,905 bp
  • T to A, chromosome 13 at 67,317,647 bp
  • T to A, chromosome 14 at 14,733,750 bp
  • T to C, chromosome 14 at 50,844,487 bp
  • A to G, chromosome 15 at 27,608,746 bp
  • A to G, chromosome 15 at 72,693,619 bp
  • A to G, chromosome 16 at 44,243,497 bp
  • C to T, chromosome 16 at 64,770,788 bp
  • T to C, chromosome 17 at 28,806,637 bp
  • A to T, chromosome 17 at 30,704,724 bp
  • T to C, chromosome 17 at 43,310,602 bp
  • T to G, chromosome 17 at 56,628,811 bp
  • A to G, chromosome 17 at 57,067,915 bp
  • T to C, chromosome 17 at 57,206,276 bp
  • A to G, chromosome 18 at 25,090,162 bp
  • C to T, chromosome 18 at 56,491,945 bp
  • A to G, chromosome 18 at 60,695,500 bp
  • A to G, chromosome 19 at 12,088,166 bp
  • G to A, chromosome X at 74,306,855 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7099 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045191-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.