Strain Name:
C57BL/6J-MtgxR7100Btlr/Mmmh
Stock Number:
045192-MU
Citation ID:
RRID:MMRRC_045192-MU
Other Names:
R7100 (G1)
Major Collection:

Strain Information

Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: Cdc2l1, CDK11-p58, CDK11-p46, PITSLRE proteins, CDK11-p110, Cdc2l2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Maco1
Name: macoilin 1
Synonyms: 1110007C24Rik, 9230118A01Rik, C61, Tmem57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66146
Homologene: 14449
Lmna
Name: lamin A
Synonyms: Dhe, lamin A/C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16905
HGNC: HGNC:6636
Homologene: 41321
Mid1
Name: midline 1
Synonyms: 61B3-R, Fxy, DXHXS1141, Trim18
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 17318
HGNC: HGNC:7095
Homologene: 7837
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: E130113K22Rik, CGI-72
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4932439K10Rik, Specc1l, 4930470P14Rik, 9530057A13Rik, Cytsa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67553
Homologene: 11693
Ppp2r5d
Name: protein phosphatase 2, regulatory subunit B', delta
Synonyms: Tex271, TEG-271, B'delta
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21770
VEGA: 17
HGNC: HGNC:9312
Homologene: 37661
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84585
Homologene: 11112
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, hlb381, Ras GTPase-activating protein III, GAPIII, GAPIII activator 3, scat
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19414
Homologene: 7217
Cpxm2
Name: carboxypeptidase X, M14 family member 2
Synonyms: 4632435C11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55987
Homologene: 69259
Amph
Name: amphiphysin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, Inoc1, 4632409L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, C230081A13Rik, NKF3 kinase family member
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
Synonyms: REV-ERBalpha, A530070C09Rik, rev-erbA(alpha)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217166
HGNC: HGNC:7962
Homologene: 23324
Amdhd1
Name: amidohydrolase domain containing 1
Synonyms: 1300019J08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71761
Homologene: 14730
Fut4
Name: fucosyltransferase 4
Synonyms: 3-fucosyl-N-acetyl-lactosamine epitope, FucT-IV, FAL, SSEA-1, LeX, Ssea1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14345
VEGA: 9
HGNC: HGNC:4015
Homologene: 1538
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Klk1
Name: kallikrein 1
Synonyms: Klk6, mGk-6, 0610007D04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16612
Homologene: 68141
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: C030033M19Rik, RIM1alpha, RIM1, RIM1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Trpc3
Name: transient receptor potential cation channel, subfamily C, member 3
Synonyms: Trrp3, Trp3, Trcp3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22065
Homologene: 20708
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17076
Homologene: 31085
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: alpha-1 antiproteinase, Spi2A, alpha-1 antiproteinase,, Spi2-1, 2A2, Spi2/eb.1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Mus81
Name: MUS81 structure-specific endonuclease subunit
Synonyms: 1200008A18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71711
Homologene: 5725
Pcgf6
Name: polycomb group ring finger 6
Synonyms: Rnf134, 4933407A11Rik, MBLR, Mel18 and Bmi1-like RING finger protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71041
VEGA: 19
Homologene: 12378
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl-II, CD110, c-mpl-I, hlb219, TPO-R, thrombopoietin receptor, c-mpl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Nmt2
Name: N-myristoyltransferase 2
Synonyms: A930001K02Rik, hNMT-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18108
HGNC: HGNC:7858
Homologene: 101539
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Plaat5
Name: phospholipase A and acyltransferase 5
Synonyms: iNAT, 1700086E08Rik, 1700055A14Rik, 4921526K24Rik, Hrasls5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66727
Homologene: 12019
Slc24a5
Name: solute carrier family 24, member 5
Synonyms: Oca6, F630045L20Rik, NCKX5, NCX5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 317750
Homologene: 18400
Vnn3
Name: vanin 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26464
Homologene: 48295
Actl10
Name: actin-like 10
Synonyms: 1700007I08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70362
Homologene: 128516
Vmn1r177
Name: vomeronasal 1 receptor 177
Synonyms: V1rd12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384572
Homologene: 122945
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: Lr8b, 4932703M08Rik, apoER2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Hycc2
Name: hyccin PI4KA lipid kinase complex subunit 2
Synonyms: Fam126b, D1Ertd53e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213056
Homologene: 18184
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215008
Homologene: 9739
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Upp2
Name: uridine phosphorylase 2
Synonyms: 1700124F02Rik, UPASE2, UDRPASE2, UP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76654
Homologene: 12654
Arl2
Name: ADP-ribosylation factor-like 2
Synonyms: arf-like protein 2, 2610009M23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56327
HGNC: HGNC:693
Homologene: 1260
Tagap1
Name: T cell activation GTPase activating protein 1
Synonyms: 2610315E15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 380608
VEGA: 17
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Mifl, Herp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64209
Homologene: 40973
Irf2bp2
Name: interferon regulatory factor 2 binding protein 2
Synonyms: E130305N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270110
Homologene: 34290
Fam181a
Name: family with sequence similarity 181, member A
Synonyms: EG544888
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100504156
Homologene: 34701
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 22,346,473 bp
  • T to A, chromosome 1 at 58,534,494 bp
  • T to A, chromosome 2 at 3,312,913 bp
  • G to T, chromosome 2 at 58,791,805 bp
  • A to G, chromosome 2 at 60,306,434 bp
  • A to T, chromosome 2 at 76,710,822 bp
  • A to G, chromosome 2 at 119,374,513 bp
  • A to C, chromosome 2 at 125,080,671 bp
  • A to G, chromosome 2 at 154,552,395 bp
  • C to A, chromosome 3 at 36,650,067 bp
  • A to G, chromosome 3 at 76,536,293 bp
  • A to G, chromosome 3 at 88,484,990 bp
  • A to T, chromosome 3 at 93,203,711 bp
  • G to T, chromosome 3 at 133,084,943 bp
  • C to A, chromosome 4 at 107,802,450 bp
  • G to T, chromosome 4 at 118,457,410 bp
  • T to C, chromosome 4 at 134,806,660 bp
  • C to T, chromosome 4 at 140,516,815 bp
  • T to A, chromosome 4 at 155,625,593 bp
  • C to A, chromosome 7 at 12,581,586 bp
  • A to G, chromosome 7 at 23,866,110 bp
  • T to C, chromosome 7 at 39,408,284 bp
  • G to A, chromosome 7 at 44,229,424 bp
  • G to T, chromosome 7 at 118,184,520 bp
  • C to T, chromosome 7 at 132,054,815 bp
  • T to A, chromosome 7 at 144,411,164 bp
  • T to C, chromosome 8 at 13,586,897 bp
  • A to G, chromosome 8 at 94,390,847 bp
  • G to A, chromosome 8 at 125,759,114 bp
  • T to C, chromosome 8 at 126,591,733 bp
  • A to G, chromosome 9 at 14,751,393 bp
  • A to G, chromosome 9 at 56,259,393 bp
  • C to T, chromosome 9 at 108,056,639 bp
  • C to T, chromosome 10 at 17,915,373 bp
  • T to C, chromosome 10 at 23,865,942 bp
  • T to G, chromosome 10 at 75,245,495 bp
  • T to C, chromosome 10 at 93,537,074 bp
  • T to A, chromosome 10 at 93,996,933 bp
  • C to A, chromosome 11 at 98,771,334 bp
  • T to C, chromosome 12 at 101,446,038 bp
  • T to A, chromosome 12 at 103,315,873 bp
  • T to C, chromosome 12 at 104,238,311 bp
  • T to C, chromosome 13 at 19,149,841 bp
  • A to T, chromosome 13 at 81,270,897 bp
  • A to G, chromosome 13 at 112,356,110 bp
  • T to A, chromosome 13 at 113,318,967 bp
  • A to G, chromosome 15 at 66,604,840 bp
  • A to T, chromosome 15 at 76,596,114 bp
  • A to T, chromosome 17 at 6,956,712 bp
  • T to C, chromosome 17 at 33,911,442 bp
  • A to G, chromosome 17 at 46,685,682 bp
  • A to T, chromosome 18 at 12,582,644 bp
  • T to C, chromosome 19 at 4,918,041 bp
  • C to T, chromosome 19 at 5,484,211 bp
  • C to A, chromosome 19 at 6,134,744 bp
  • T to A, chromosome 19 at 7,639,558 bp
  • G to A, chromosome 19 at 47,050,714 bp
  • A to G, chromosome X at 169,985,077 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7100 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045192-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.