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Strain Name:
C57BL/6J-MtgxR7102Btlr/Mmmh
Stock Number:
045194-MU
Citation ID:
RRID:MMRRC_045194-MU
Other Names:
R7102 (G1)
Major Collection:

Strain Information

Cdk6
Name: cyclin dependent kinase 6
Synonyms: Crk2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12571
HGNC: HGNC:1777
Homologene: 963
Pax6
Name: paired box 6
Synonyms: Pax-6, Dey, Dickie's small eye, 1500038E17Rik, AEY11, Gsfaey11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Elavl3
Name: ELAV like RNA binding protein 3
Synonyms: mHuC, Huc, 2600009P04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15571
VEGA: 9
HGNC: HGNC:3314
Homologene: 31035
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Ythdf1
Name: YTH N6-methyladenosine RNA binding protein 1
Synonyms: 2210410K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228994
Homologene: 9844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 40,580,639 bp
  • T to C, chromosome 1 at 40,623,399 bp
  • T to C, chromosome 1 at 74,622,223 bp
  • C to T, chromosome 1 at 150,452,254 bp
  • A to G, chromosome 1 at 186,100,327 bp
  • G to T, chromosome 2 at 10,105,763 bp
  • A to T, chromosome 2 at 16,142,303 bp
  • T to A, chromosome 2 at 52,304,055 bp
  • T to A, chromosome 2 at 66,549,015 bp
  • C to A, chromosome 2 at 69,897,822 bp
  • T to A, chromosome 2 at 88,487,148 bp
  • C to A, chromosome 2 at 92,413,093 bp
  • C to A, chromosome 2 at 105,692,259 bp
  • T to A, chromosome 2 at 121,046,498 bp
  • A to T, chromosome 2 at 130,309,731 bp
  • A to C, chromosome 2 at 131,178,879 bp
  • A to G, chromosome 2 at 155,622,199 bp
  • G to A, chromosome 2 at 180,911,522 bp
  • T to C, chromosome 3 at 27,470,234 bp
  • T to G, chromosome 3 at 36,940,798 bp
  • A to G, chromosome 3 at 75,112,094 bp
  • T to A, chromosome 3 at 93,293,028 bp
  • T to C, chromosome 3 at 117,323,183 bp
  • T to C, chromosome 3 at 144,961,909 bp
  • A to T, chromosome 3 at 146,055,704 bp
  • T to A, chromosome 4 at 48,407,674 bp
  • A to G, chromosome 4 at 88,603,151 bp
  • G to A, chromosome 4 at 112,118,101 bp
  • T to C, chromosome 5 at 3,520,709 bp
  • T to G, chromosome 5 at 8,694,072 bp
  • T to A, chromosome 5 at 26,057,384 bp
  • A to G, chromosome 5 at 96,571,041 bp
  • A to G, chromosome 5 at 137,454,200 bp
  • T to A, chromosome 6 at 50,320,135 bp
  • C to T, chromosome 6 at 113,194,145 bp
  • G to T, chromosome 6 at 113,686,849 bp
  • T to A, chromosome 6 at 116,413,468 bp
  • T to C, chromosome 6 at 119,948,307 bp
  • T to A, chromosome 7 at 6,065,709 bp
  • T to C, chromosome 7 at 12,890,472 bp
  • T to A, chromosome 7 at 24,180,658 bp
  • T to C, chromosome 7 at 29,348,587 bp
  • T to C, chromosome 7 at 33,280,286 bp
  • T to A, chromosome 7 at 46,819,126 bp
  • C to A, chromosome 7 at 79,836,313 bp
  • C to T, chromosome 7 at 86,616,267 bp
  • T to A, chromosome 7 at 140,504,316 bp
  • T to A, chromosome 7 at 142,202,255 bp
  • T to A, chromosome 8 at 70,301,076 bp
  • A to G, chromosome 8 at 72,695,329 bp
  • T to A, chromosome 8 at 125,730,055 bp
  • G to T, chromosome 9 at 22,018,729 bp
  • C to T, chromosome 9 at 22,579,553 bp
  • C to A, chromosome 9 at 59,976,304 bp
  • T to A, chromosome 9 at 62,421,385 bp
  • C to T, chromosome 9 at 119,432,553 bp
  • A to G, chromosome 9 at 122,929,804 bp
  • C to T, chromosome 10 at 4,353,226 bp
  • T to A, chromosome 10 at 58,463,950 bp
  • A to T, chromosome 10 at 112,092,425 bp
  • A to T, chromosome 10 at 128,516,236 bp
  • A to C, chromosome 10 at 129,388,167 bp
  • A to T, chromosome 11 at 9,335,215 bp
  • G to A, chromosome 11 at 50,862,977 bp
  • G to A, chromosome 11 at 55,283,434 bp
  • A to C, chromosome 11 at 101,088,976 bp
  • C to A, chromosome 11 at 113,842,690 bp
  • C to A, chromosome 11 at 120,921,731 bp
  • T to C, chromosome 12 at 25,057,663 bp
  • C to T, chromosome 12 at 32,974,255 bp
  • T to C, chromosome 12 at 70,953,031 bp
  • G to A, chromosome 12 at 84,417,771 bp
  • A to G, chromosome 13 at 9,604,536 bp
  • C to T, chromosome 13 at 58,588,214 bp
  • C to T, chromosome 14 at 12,603,738 bp
  • T to A, chromosome 14 at 14,828,517 bp
  • T to C, chromosome 14 at 45,205,382 bp
  • G to A, chromosome 14 at 103,543,832 bp
  • T to A, chromosome 14 at 108,912,629 bp
  • T to A, chromosome 15 at 4,948,003 bp
  • T to C, chromosome 15 at 36,122,313 bp
  • T to C, chromosome 15 at 78,297,072 bp
  • T to C, chromosome 15 at 97,245,860 bp
  • A to T, chromosome 16 at 7,369,834 bp
  • G to A, chromosome 16 at 20,604,234 bp
  • A to G, chromosome 16 at 35,299,625 bp
  • G to A, chromosome 17 at 8,256,187 bp
  • T to A, chromosome 17 at 23,954,634 bp
  • T to A, chromosome 17 at 25,474,744 bp
  • T to A, chromosome 17 at 48,366,672 bp
  • A to G, chromosome 17 at 78,624,997 bp
  • T to A, chromosome 18 at 12,552,813 bp
  • T to A, chromosome 19 at 5,503,595 bp
  • T to A, chromosome 19 at 5,570,187 bp
  • C to T, chromosome 19 at 7,358,442 bp
  • T to A, chromosome 19 at 17,121,213 bp
  • G to T, chromosome 19 at 36,919,206 bp
  • T to C, chromosome 19 at 37,174,719 bp
  • T to A, chromosome 19 at 60,832,596 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7102 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045194-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.