Strain Name:
C57BL/6J-MtgxR7104Btlr/Mmmh
Stock Number:
045196-MU
Citation ID:
RRID:MMRRC_045196-MU
Other Names:
R7104 (G1)
Major Collection:

Strain Information

Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: NO, 2310005C01Rik, nNOS, bNOS, Nos-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Ndrg1
Name: N-myc downstream regulated gene 1
Synonyms: Ndr1, CMT4D, Ndrl, CAP43, TDD5, DRG1, Tdd5, PROXY1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17988
HGNC: HGNC:7679
Homologene: 55953
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, 2810012K13Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: p66beta, C430014D17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: an, 2900018K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68014
Homologene: 32381
Pip4k2b
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Synonyms: PI5P4Kbeta, c11, Pip5k2b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108083
HGNC: HGNC:8998
Homologene: 2634
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: 1110014O20Rik, Stank, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: JPDI, 1200006L06Rik, D2Ertd706e, ERdj5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66861
Homologene: 10358
Atf7
Name: activating transcription factor 7
Synonyms: 1110012F10Rik, 9430065F09Rik, C130020M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223922
HGNC: HGNC:792
Homologene: 4994
Itgb3bp
Name: integrin beta 3 binding protein (beta3-endonexin)
Synonyms: 4930471O16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67733
HGNC: HGNC:6157
Homologene: 8617
Grk6
Name: G protein-coupled receptor kinase 6
Synonyms: Gprk6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26385
VEGA: 13
HGNC: HGNC:4545
Homologene: 37570
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: D9Ertd280e, Fam62c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272636
Homologene: 18626
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, Zfh-4, C130041O22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, 2410089E03Rik, b2b012Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Or8b12b
Name: olfactory receptor family 8 subfamily B member 12B
Synonyms: GA_x6K02T2PVTD-31458511-31459443, MOR161-4, Olfr875
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258744
Homologene: 121527
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: Ccdc135, SRG-L, LOC330830
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330830
Homologene: 12996
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Vmn2r85
Name: vomeronasal 2, receptor 85
Synonyms: EG623734
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 623734
Homologene: 129606
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Cytip
Name: cytohesin 1 interacting protein
Synonyms: A130053M09Rik, Cbp, Pscdbp, Cybr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227929
HGNC: HGNC:9506
Homologene: 3167
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Vwc2l
Name: von Willebrand factor C domain-containing protein 2-like
Synonyms: Brl, A830006F12Rik, brorin-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320460
Homologene: 27945
Or4a69
Name: olfactory receptor family 4 subfamily A member 69
Synonyms: Olfr1241, GA_x6K02T2Q125-50926215-50925271, MOR231-14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258447
Homologene: 74067
Prl8a8
Name: prolactin family 8, subfamily a, member 81
Synonyms: 1600032B14Rik, Prlpc3, PLP-Cgamma
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74188
Homologene: 137338
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: Kv11.3, erg3, 9330137I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170738
Homologene: 13249
Engase
Name: endo-beta-N-acetylglucosaminidase
Synonyms: D230014K01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217364
Homologene: 13666
Vmn2r37
Name: vomeronasal 2, receptor 37
Synonyms: V2r14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22305
Homologene: 113703
Tnfsf15
Name: tumor necrosis factor (ligand) superfamily, member 15
Synonyms: TL1A, VEGI, TL1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 326623
Homologene: 3755
Unc5c
Name: unc-5 netrin receptor C
Synonyms: B130051O18Rik, Unc5h3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: A430081C19Rik, Ccp2, Ccp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271813
Homologene: 11715
Krt2
Name: keratin 2
Synonyms: Krt2-17, Krt2e, Krt2-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp4c, Rnh2, Nalp-alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83564
Homologene: 75315
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: MOR172-1, GA_x6K02T2Q125-47777498-47778436, Olfr1052
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259012
Homologene: 79679
Or5an9
Name: olfactory receptor family 5 subfamily AN member 9
Synonyms: MOR214-5, Olfr1431, GA_x6K02T2RE5P-2573738-2574676
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258409
Homologene: 115495
Cdk14
Name: cyclin dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Sema6c
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms: Sema Y, Semay
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20360
Homologene: 7931
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385674
Homologene: 55755
Prl7c1
Name: prolactin family 7, subfamily c, member 1
Synonyms: PLP-O, Prlpo, 1600017N11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67505
Homologene: 137377
Rbfox1
Name: RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms: A2bp, FOX1, A2bp1, HRNBP1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268859
VEGA: 16
Homologene: 69339
Ttyh3
Name: tweety family member 3
Synonyms: 2900029G13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78339
Homologene: 18431
Or14a256
Name: olfactory receptor family 14 subfamily A member 256
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5, Olfr294
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257904
Septin12
Name: septin 12
Synonyms: 4933413B09Rik, Sept12, 1700028G04Rik, Septin12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71089
VEGA: 16
Homologene: 69435
Pttg1
Name: pituitary tumor-transforming gene 1
Synonyms: securin, PTTG
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30939
Homologene: 3110
Or5d39
Name: olfactory receptor family 5 subfamily D member 39
Synonyms: MOR174-16, Olfr1167, GA_x6K02T2Q125-49641892-49640942
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258291
Homologene: 138307
Rnase2a
Name: ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin)
Synonyms: Ear11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93726
VEGA: 14
Homologene: 121614
Prg3
Name: proteoglycan 3
Synonyms: major basic protein 2, MBP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53856
HGNC: HGNC:9363
Homologene: 4441
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 70,729,093 bp
  • A to G, chromosome 2 at 58,159,974 bp
  • G to T, chromosome 2 at 62,787,687 bp
  • T to A, chromosome 2 at 80,340,815 bp
  • T to C, chromosome 2 at 84,988,753 bp
  • T to A, chromosome 2 at 86,298,220 bp
  • T to C, chromosome 2 at 88,149,372 bp
  • A to G, chromosome 2 at 89,483,114 bp
  • A to G, chromosome 2 at 90,797,547 bp
  • A to T, chromosome 3 at 5,402,489 bp
  • A to T, chromosome 3 at 83,919,459 bp
  • T to A, chromosome 3 at 90,351,417 bp
  • A to G, chromosome 3 at 95,168,845 bp
  • T to C, chromosome 3 at 141,733,904 bp
  • T to C, chromosome 4 at 63,729,650 bp
  • G to T, chromosome 4 at 70,349,156 bp
  • T to G, chromosome 4 at 82,940,681 bp
  • A to G, chromosome 4 at 99,814,098 bp
  • A to G, chromosome 5 at 5,195,325 bp
  • T to A, chromosome 5 at 117,947,431 bp
  • T to C, chromosome 5 at 140,629,785 bp
  • A to T, chromosome 6 at 12,379,430 bp
  • A to G, chromosome 6 at 38,818,644 bp
  • C to T, chromosome 6 at 149,044,604 bp
  • T to A, chromosome 7 at 6,065,709 bp
  • A to T, chromosome 7 at 9,216,046 bp
  • T to C, chromosome 7 at 42,928,535 bp
  • T to C, chromosome 7 at 86,615,692 bp
  • T to C, chromosome 7 at 128,198,378 bp
  • A to G, chromosome 8 at 95,059,083 bp
  • A to T, chromosome 9 at 37,773,141 bp
  • A to G, chromosome 9 at 42,366,943 bp
  • A to G, chromosome 9 at 64,161,376 bp
  • T to A, chromosome 9 at 74,148,315 bp
  • C to A, chromosome 9 at 99,338,787 bp
  • A to T, chromosome 10 at 130,426,507 bp
  • G to C, chromosome 11 at 43,421,149 bp
  • T to C, chromosome 11 at 97,732,716 bp
  • G to A, chromosome 11 at 118,481,295 bp
  • C to T, chromosome 12 at 51,827,351 bp
  • A to T, chromosome 13 at 27,511,496 bp
  • A to T, chromosome 13 at 27,778,969 bp
  • A to T, chromosome 13 at 42,157,338 bp
  • A to T, chromosome 13 at 51,431,205 bp
  • A to T, chromosome 13 at 51,656,907 bp
  • T to C, chromosome 13 at 55,454,406 bp
  • T to G, chromosome 14 at 51,255,531 bp
  • A to G, chromosome 14 at 51,413,796 bp
  • T to C, chromosome 15 at 8,194,444 bp
  • A to G, chromosome 15 at 66,946,528 bp
  • T to C, chromosome 15 at 101,815,087 bp
  • A to G, chromosome 15 at 102,534,235 bp
  • C to T, chromosome 16 at 3,854,405 bp
  • A to G, chromosome 16 at 4,991,993 bp
  • C to A, chromosome 16 at 7,353,003 bp
  • C to A, chromosome 16 at 37,089,353 bp
  • T to C, chromosome 19 at 12,209,878 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7104 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045196-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.