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Strain Name:
C57BL/6J-MtgxR7124Btlr/Mmmh
Stock Number:
045212-MU
Citation ID:
RRID:MMRRC_045212-MU
Other Names:
R7124 (G1)
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik, D630049N15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Npy2r
Name: neuropeptide Y receptor Y2
Synonyms: NPY-Y2 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18167
HGNC: HGNC:7957
Homologene: 701
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: 9430023P16Rik, Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Sfpq
Name: splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
Synonyms: D4Ertd314e, 9030402K04Rik, 2810416M14Rik, 5730453G22Rik, 1110004P21Rik, REP1, PSF
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71514
Homologene: 3714
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 130,742,887 bp
  • T to C, chromosome 1 at 152,878,080 bp
  • C to A, chromosome 1 at 183,087,466 bp
  • C to T, chromosome 2 at 26,356,884 bp
  • T to C, chromosome 2 at 85,849,910 bp
  • T to A, chromosome 2 at 85,951,473 bp
  • T to C, chromosome 2 at 91,162,048 bp
  • T to C, chromosome 2 at 101,643,783 bp
  • C to T, chromosome 2 at 155,829,571 bp
  • A to G, chromosome 3 at 55,992,444 bp
  • G to A, chromosome 3 at 82,541,183 bp
  • T to A, chromosome 3 at 96,651,765 bp
  • C to A, chromosome 3 at 116,565,913 bp
  • A to C, chromosome 3 at 124,414,393 bp
  • T to C, chromosome 4 at 32,996,027 bp
  • A to T, chromosome 4 at 126,180,438 bp
  • A to T, chromosome 4 at 127,025,932 bp
  • T to A, chromosome 4 at 136,009,141 bp
  • G to T, chromosome 4 at 152,131,264 bp
  • A to G, chromosome 4 at 152,555,684 bp
  • A to T, chromosome 5 at 96,714,401 bp
  • T to A, chromosome 5 at 105,119,959 bp
  • A to G, chromosome 5 at 107,830,851 bp
  • G to T, chromosome 5 at 121,519,334 bp
  • T to C, chromosome 5 at 143,289,607 bp
  • A to G, chromosome 5 at 144,750,911 bp
  • T to A, chromosome 6 at 30,441,827 bp
  • A to T, chromosome 6 at 38,818,478 bp
  • T to C, chromosome 6 at 39,111,736 bp
  • A to T, chromosome 6 at 83,088,064 bp
  • A to G, chromosome 6 at 84,190,901 bp
  • C to T, chromosome 7 at 7,334,184 bp
  • T to A, chromosome 7 at 12,622,151 bp
  • C to T, chromosome 7 at 13,988,395 bp
  • C to A, chromosome 7 at 18,814,496 bp
  • C to G, chromosome 7 at 18,814,497 bp
  • G to T, chromosome 8 at 15,903,202 bp
  • T to C, chromosome 8 at 27,273,419 bp
  • A to G, chromosome 8 at 60,671,269 bp
  • A to T, chromosome 8 at 61,516,645 bp
  • T to A, chromosome 8 at 71,333,701 bp
  • T to C, chromosome 8 at 71,932,540 bp
  • G to A, chromosome 8 at 85,518,052 bp
  • T to C, chromosome 8 at 118,968,173 bp
  • G to A, chromosome 8 at 125,753,617 bp
  • T to C, chromosome 9 at 14,736,900 bp
  • T to C, chromosome 9 at 98,577,053 bp
  • A to T, chromosome 10 at 39,822,167 bp
  • C to A, chromosome 11 at 69,737,462 bp
  • A to G, chromosome 11 at 77,454,338 bp
  • T to C, chromosome 11 at 104,738,274 bp
  • C to T, chromosome 11 at 115,269,577 bp
  • G to T, chromosome 12 at 103,061,393 bp
  • T to C, chromosome 12 at 103,451,320 bp
  • G to T, chromosome 12 at 112,122,983 bp
  • G to T, chromosome 12 at 119,202,424 bp
  • A to C, chromosome 13 at 59,702,487 bp
  • G to A, chromosome 14 at 31,160,867 bp
  • C to T, chromosome 14 at 31,336,685 bp
  • A to G, chromosome 14 at 56,602,799 bp
  • A to G, chromosome 14 at 65,608,802 bp
  • G to A, chromosome 15 at 40,144,907 bp
  • T to C, chromosome 15 at 54,462,371 bp
  • T to A, chromosome 15 at 75,973,549 bp
  • A to T, chromosome 15 at 83,629,511 bp
  • G to T, chromosome 15 at 85,071,597 bp
  • T to C, chromosome 16 at 4,864,332 bp
  • T to G, chromosome 16 at 23,012,055 bp
  • T to C, chromosome 16 at 36,913,673 bp
  • T to C, chromosome 16 at 88,611,546 bp
  • T to A, chromosome 17 at 21,742,616 bp
  • A to G, chromosome 17 at 32,914,588 bp
  • T to C, chromosome 18 at 80,117,125 bp
  • T to C, chromosome 19 at 43,614,806 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7124 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045212-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.