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Strain Name:
C57BL/6J-MtgxR7136Btlr/Mmmh
Stock Number:
045220-MU
Citation ID:
RRID:MMRRC_045220-MU
Other Names:
R7136 (G1)
Major Collection:

Strain Information

Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, bNOS, Nos-1, NO, 2310005C01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Wdr82
Name: WD repeat domain containing 82
Synonyms: 9430077D24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77305
Homologene: 42951
Kdm3a
Name: lysine (K)-specific demethylase 3A
Synonyms: 1700105C21Rik, Tsga, C230043E16Rik, Jmjd1, Jmjd1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 104263
Homologene: 10196
Wasf1
Name: WASP family, member 1
Synonyms: WAVE-1, Scar, WAVE
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83767
Homologene: 2920
Med13l
Name: mediator complex subunit 13-like
Synonyms: 2210413I17Rik, 6330591G05Rik, Trap240L, 9030618F05Rik, Thrap2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC155, RPC1, 9330175N20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: Bcrp, 4930430M16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74213
Homologene: 41468
Zdhhc13
Name: zinc finger, DHHC domain containing 13
Synonyms: kojak, 2410004E01Rik, Hip14l, skc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243983
Homologene: 75106
Stmn1
Name: stathmin 1
Synonyms: leukemia associated phosphoprotein p18, prosolin, Lap18, op18, p18, p19, 19K, SMN, PR22, PP18, PP17, Lag, pig, metablastin, oncoprotein18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16765
HGNC: HGNC:6510
Homologene: 4063
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74775
Homologene: 10011
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Cbln2
Name: cerebellin 2 precursor protein
Synonyms: 6330593N19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12405
HGNC: HGNC:1544
Homologene: 18203
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Fuca2
Name: fucosidase, alpha-L- 2, plasma
Synonyms: 5530401P20Rik, 0610025O11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66848
HGNC: HGNC:4008
Homologene: 119
Ube2e3
Name: ubiquitin-conjugating enzyme E2E 3
Synonyms: ubcM2, Ubce4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22193
Homologene: 4636
Tbl2
Name: transducin (beta)-like 2
Synonyms: WS-bTRP, C76179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27368
Homologene: 8260
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 5730465C04Rik, 1700087N07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Fbxl19
Name: F-box and leucine-rich repeat protein 19
Synonyms: Fbl19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233902
Homologene: 129692
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberin, Nafld, tuberous sclerosis 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Pink1
Name: PTEN induced putative kinase 1
Synonyms: 1190006F07Rik, brpk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68943
Homologene: 32672
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
1700123K08Rik
Name: RIKEN cDNA 1700123K08 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76658
Homologene: 86127
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Eps8l1
Name: EPS8-like 1
Synonyms: 4632407K17Rik, EPS8R1, DRC3, 2310051G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67425
Homologene: 15767
Kcnk7
Name: potassium channel, subfamily K, member 7
Synonyms: Mlk3, Knot, Kcnk8, 2310014G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16530
HGNC: HGNC:6282
Homologene: 43131
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75823
Homologene: 27384
Or5k3
Name: olfactory receptor family 5 subfamily K member 3
Synonyms: GA_x54KRFPKG5P-55369823-55370749, MOR184-5, Olfr195
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259000
Homologene: 128109
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, 4732458A06Rik, D130016K21Rik, 9430063L05Rik, Usmg4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Qprt
Name: quinolinate phosphoribosyltransferase
Synonyms: QPRTase, nicotinate-nucleotide pyrophosphorylase, 2410027J01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67375
HGNC: HGNC:9755
Homologene: 8623
Il12b
Name: interleukin 12b
Synonyms: Il-12p40, IL-12 p40, Il-12b, IL-23 subunit p40
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16160
HGNC: HGNC:5970
Homologene: 1648
Osgin1
Name: oxidative stress induced growth inhibitor 1
Synonyms: 1700012B18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71839
Homologene: 16325
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: CDC25Mm, Grfbeta, CDC25, Grf1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Ccdc157
Name: coiled-coil domain containing 157
Synonyms: 4930562D19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216516
Homologene: 72271
Vmn1r13
Name: vomeronasal 1 receptor 13
Synonyms: V1rc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113862
Homologene: 74368
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Synonyms: 25-hydroxyvitamin D-24-hydroxylase, 24-OHase, CP24, Cyp24
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13081
HGNC: HGNC:2602
Homologene: 68094
Vps52
Name: VPS52 GARP complex subunit
Synonyms: ARE1, tcl-w5, D430041K17Rik, Sacm2l, tclw5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224705
Homologene: 5756
H2-Q1
Name: histocompatibility 2, Q region locus 1
Synonyms: H-2Q1, Q1k, Q1d, Q1b, Q1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15006
Homologene: 128352
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 2810483I07Rik, UBP-M, 1200004E02Rik, 6330514E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Slc7a15
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
Synonyms: 2010001P20Rik, Arpat, 9030221C07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328059
Homologene: 77627
Prkar1b
Name: protein kinase, cAMP dependent regulatory, type I beta
Synonyms: RIbeta
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19085
HGNC: HGNC:9390
Homologene: 37665
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 675969
Homologene: 104330
Qars1
Name: glutaminyl-tRNA synthetase 1
Synonyms: 1110018N24Rik, 1200016L19Rik, Qars
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Mesp1
Name: mesoderm posterior 1
Synonyms: bHLHc5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17292
Homologene: 32039
Hgh1
Name: HGH1 homolog
Synonyms: D15Ertd741e, Brp16, Fam203a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 59053
VEGA: 15
Homologene: 48742
Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms: Gwt1, 2610044A17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70325
Homologene: 6243
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328381
Homologene: 19164
Pttg1ip2
Name: PTTG1IP family member 2
Synonyms: LOC381716, 1700015F17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381716
Homologene: 136447
Or7c70
Name: olfactory receptor family 7 subfamily C member 70
Synonyms: GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p, MOR142-1, Olfr1356
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258305
Homologene: 71958
Krbox5
Name: KRAB box domain containing 5
Synonyms: EG328280, Gm10037
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102637366
VEGA: 13
Mrgpra2a
Name: MAS-related GPR, member A2A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668727
Homologene: 79615
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 76,836,560 bp
  • T to C, chromosome 2 at 78,913,741 bp
  • T to G, chromosome 2 at 126,124,028 bp
  • A to T, chromosome 2 at 143,949,680 bp
  • A to T, chromosome 2 at 170,494,143 bp
  • T to C, chromosome 3 at 19,231,094 bp
  • C to T, chromosome 3 at 19,985,658 bp
  • C to T, chromosome 3 at 97,694,063 bp
  • T to C, chromosome 3 at 113,563,599 bp
  • T to C, chromosome 4 at 43,669,845 bp
  • A to G, chromosome 4 at 134,470,777 bp
  • T to C, chromosome 4 at 138,317,458 bp
  • A to T, chromosome 5 at 5,466,631 bp
  • A to T, chromosome 5 at 24,332,991 bp
  • G to T, chromosome 5 at 117,895,860 bp
  • A to G, chromosome 5 at 118,721,522 bp
  • T to G, chromosome 5 at 135,149,828 bp
  • A to G, chromosome 5 at 138,562,348 bp
  • C to A, chromosome 5 at 139,108,608 bp
  • C to T, chromosome 6 at 40,900,053 bp
  • T to C, chromosome 6 at 57,210,254 bp
  • T to G, chromosome 6 at 58,684,340 bp
  • G to A, chromosome 6 at 71,611,780 bp
  • A to G, chromosome 7 at 4,477,404 bp
  • T to A, chromosome 7 at 28,883,107 bp
  • A to T, chromosome 7 at 47,427,186 bp
  • A to G, chromosome 7 at 48,801,332 bp
  • T to C, chromosome 7 at 79,793,158 bp
  • T to A, chromosome 7 at 86,228,767 bp
  • T to C, chromosome 7 at 127,108,812 bp
  • C to A, chromosome 7 at 127,750,045 bp
  • T to C, chromosome 8 at 95,103,449 bp
  • T to A, chromosome 8 at 119,441,437 bp
  • A to G, chromosome 9 at 16,378,185 bp
  • C to T, chromosome 9 at 52,086,445 bp
  • T to A, chromosome 9 at 89,991,598 bp
  • A to G, chromosome 9 at 106,171,333 bp
  • T to C, chromosome 9 at 108,512,772 bp
  • T to C, chromosome 10 at 13,505,921 bp
  • A to T, chromosome 10 at 40,926,591 bp
  • T to C, chromosome 10 at 78,847,781 bp
  • C to T, chromosome 10 at 127,558,622 bp
  • C to T, chromosome 11 at 4,148,592 bp
  • T to C, chromosome 11 at 44,408,030 bp
  • C to T, chromosome 11 at 69,348,438 bp
  • G to A, chromosome 11 at 84,877,759 bp
  • A to G, chromosome 11 at 106,205,004 bp
  • A to G, chromosome 11 at 107,099,715 bp
  • G to T, chromosome 12 at 8,538,895 bp
  • A to G, chromosome 13 at 55,379,695 bp
  • A to G, chromosome 13 at 67,842,992 bp
  • C to T, chromosome 14 at 24,461,815 bp
  • T to C, chromosome 14 at 31,298,656 bp
  • T to A, chromosome 14 at 40,840,252 bp
  • T to A, chromosome 14 at 101,920,539 bp
  • T to C, chromosome 14 at 105,144,267 bp
  • G to A, chromosome 15 at 73,221,809 bp
  • A to G, chromosome 15 at 76,370,431 bp
  • C to A, chromosome 15 at 98,911,491 bp
  • G to T, chromosome 16 at 20,734,522 bp
  • C to T, chromosome 16 at 59,148,964 bp
  • T to C, chromosome 16 at 73,956,550 bp
  • G to T, chromosome 16 at 87,483,171 bp
  • T to C, chromosome 17 at 24,613,280 bp
  • T to C, chromosome 17 at 33,965,288 bp
  • T to C, chromosome 17 at 35,320,627 bp
  • T to A, chromosome 18 at 86,716,672 bp
  • A to G, chromosome 19 at 5,706,076 bp
  • A to G, chromosome 19 at 43,837,460 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7136 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045220-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.