Strain Name:
C57BL/6J-MtgxR7148Btlr/Mmmh
Stock Number:
045225-MU
Citation ID:
RRID:MMRRC_045225-MU
Other Names:
R7148 (G1)
Major Collection:

Strain Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Fzd9
Name: frizzled class receptor 9
Synonyms: mfz9, frizzled 9, Fz9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14371
HGNC: HGNC:4047
Homologene: 2619
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Smc3
Name: structural maintenance of chromosomes 3
Synonyms: SmcD, Bamacan, Mmip1, Cspg6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13006
HGNC: HGNC:2468
Homologene: 3974
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Prpf4b
Name: pre-mRNA processing factor 4B
Synonyms: Prp4, Prpk, Prp4k
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19134
VEGA: 13
Homologene: 134085
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Lman2
Name: lectin, mannose-binding 2
Synonyms: VIP36, GP36B, 1300009F09Rik, 1110003H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66890
VEGA: 13
Homologene: 4962
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: Uchrp, 2610014N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22224
Homologene: 31294
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76138
VEGA: 10
Homologene: 44912
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Rxfp3
Name: relaxin family peptide receptor 3
Synonyms: Salpr, Rln3r1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239336
Homologene: 9568
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117146
Homologene: 13775
Pex5
Name: peroxisomal biogenesis factor 5
Synonyms: ESTM1, PTS1R, Pxr1, peroxisome biogenesis factor 5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19305
HGNC: HGNC:9719
Homologene: 270
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: 5830445G22Rik, 9430010A17Rik, Whsc1l, D030027O06Rik, C130020C13Rik, D930023B08Rik, Whsc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107823
Homologene: 26175
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep-3, Rep3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Zfp346
Name: zinc finger protein 346
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26919
Homologene: 8073
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: Snf2p, 4432404A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Zfp748
Name: zinc finger protein 748
Synonyms: 2610014M12Rik, mszf54, KRAB-O, Zfp208
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212276
Homologene: 134552
Tsc22d2
Name: TSC22 domain family, member 2
Synonyms: 1810043J12Rik, 5530402M19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72033
Homologene: 8860
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Ythdc2
Name: YTH domain containing 2
Synonyms: 3010002F02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240255
Homologene: 11265
Spring1
Name: SREBF pathway regulator in golgi 1
Synonyms: 2410131K14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76792
Homologene: 32599
Tomm20l
Name: translocase of outer mitochondrial membrane 20-like
Synonyms: 4930553D19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75266
VEGA: 12
Homologene: 52617
Samd4
Name: sterile alpha motif domain containing 4
Synonyms: 4933436G17Rik, 1700111L17Rik, 1700024G08Rik, Smaug, sunk
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74480
Homologene: 19167
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224613
VEGA: 17
Homologene: 72130
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71355
Homologene: 65061
Sell
Name: selectin, lymphocyte
Synonyms: L-selectin, CD62L, LECAM-1, Ly-m22, Ly-22, Lnhr, Lyam1, Lyam-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20343
Homologene: 539
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Zim1
Name: zinc finger, imprinted 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22776
Homologene: 129793
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2810455B10Rik, PAR3beta, PAR3L, PAR3B, 2010002N16Rik, Als2cr19, 1810008K04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72823
Homologene: 35389
Rhobtb3
Name: Rho-related BTB domain containing 3
Synonyms: 1700040C17Rik, 4930503C18Rik, 2610033K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73296
Homologene: 8932
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Ces2b
Name: carboxyesterase 2B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234669
HGNC: HGNC:1864
Homologene: 135851
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Emcn
Name: endomucin
Synonyms: 0610012K22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59308
Homologene: 9438
Ces5a
Name: carboxylesterase 5A
Synonyms: LOC244598, 1700081L16Rik, 1700122C07Rik, cauxin, Ces7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67935
Homologene: 74305
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Vmn2r62
Name: vomeronasal 2, receptor 62
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546964
Homologene: 104832
Rpl27
Name: ribosomal protein L27
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19942
Homologene: 105144
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232016
Homologene: 52344
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Osm
Name: oncostatin M
Synonyms: OncoM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18413
HGNC: HGNC:8506
Homologene: 10741
Uevld
Name: UEV and lactate/malate dehyrogenase domains
Synonyms: 8430408E05Rik, Attp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54122
Homologene: 69251
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74468
Homologene: 50610
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Fam243
Name: family with sequence similarity 243
Synonyms: 4930563D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75328
VEGA: 16
Homologene: 57100
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 435916
Homologene: 135826
Kmo
Name: kynurenine 3-monooxygenase
Synonyms: kynurenine 3-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98256
HGNC: HGNC:6381
Homologene: 2729
Semp2l2a
Name: SUMO/sentrin specific peptidase 2-like 2A
Synonyms: AF366264
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 231201
Homologene: 130042
Trabd2b
Name: TraB domain containing 2B
Synonyms: Gm12824, Hkat
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666048
Homologene: 85034
Spata4
Name: spermatogenesis associated 4
Synonyms: SRG2, TSARG2, 1700001N01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69281
Homologene: 15868
Tekt2
Name: tektin 2
Synonyms: tektin-t
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24084
Homologene: 8043
Eva1a
Name: eva-1 homolog A, regulator of programmed cell death
Synonyms: Tmem166, Fam176a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232146
Homologene: 12969
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
1700024G13Rik
Name: RIKEN cDNA 1700024G13 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67085
VEGA: 14
Homologene: 28053
Or1ab2
Name: olfactory receptor family 1 subfamily AB member 2
Synonyms: GA_x6K02T2NUPS-241490-242431, MOR130-1, Olfr374
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258335
Homologene: 131127
Pjvk
Name: pejvakin
Synonyms: LOC381375, pejvakin, Dfnb59
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381375
Homologene: 19773
Sowaha
Name: sosondowah ankyrin repeat domain family member A
Synonyms: A830006N08Rik, Ankrd43
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237761
Homologene: 18488
R3hcc1
Name: R3H domain and coiled-coil containing 1
Synonyms: 1700020M16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71843
Homologene: 136250
Mars2
Name: methionine-tRNA synthetase 2 (mitochondrial)
Synonyms: C730026E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212679
Homologene: 6009
Tle7
Name: TLE family member 7
Synonyms: Gm21964
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102638837
VEGA: 8
Homologene: 131708
Nicn1
Name: nicolin 1
Synonyms: 1500032A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66257
Homologene: 11936
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,237,514 bp
  • T to A, chromosome 1 at 62,440,032 bp
  • T to C, chromosome 1 at 150,686,854 bp
  • G to A, chromosome 1 at 153,185,984 bp
  • A to G, chromosome 1 at 164,065,607 bp
  • T to A, chromosome 1 at 175,651,602 bp
  • A to G, chromosome 2 at 76,658,487 bp
  • A to T, chromosome 3 at 15,833,059 bp
  • T to A, chromosome 3 at 58,417,008 bp
  • C to T, chromosome 3 at 97,591,316 bp
  • A to T, chromosome 3 at 137,417,094 bp
  • C to T, chromosome 3 at 145,315,299 bp
  • A to G, chromosome 4 at 114,409,350 bp
  • A to G, chromosome 4 at 126,322,381 bp
  • T to C, chromosome 5 at 33,885,511 bp
  • A to C, chromosome 5 at 114,406,252 bp
  • A to G, chromosome 5 at 118,255,694 bp
  • A to G, chromosome 5 at 135,249,690 bp
  • A to G, chromosome 5 at 144,821,803 bp
  • T to A, chromosome 6 at 24,876,902 bp
  • T to C, chromosome 6 at 55,897,686 bp
  • T to G, chromosome 6 at 82,071,144 bp
  • T to A, chromosome 6 at 123,713,022 bp
  • T to G, chromosome 6 at 124,405,272 bp
  • T to C, chromosome 7 at 6,678,221 bp
  • A to G, chromosome 7 at 42,765,216 bp
  • A to G, chromosome 7 at 46,950,976 bp
  • T to A, chromosome 7 at 131,066,734 bp
  • T to A, chromosome 8 at 13,837,996 bp
  • T to C, chromosome 8 at 15,084,577 bp
  • A to C, chromosome 8 at 54,602,550 bp
  • T to A, chromosome 8 at 72,110,157 bp
  • C to T, chromosome 8 at 93,502,322 bp
  • A to G, chromosome 8 at 104,838,296 bp
  • G to T, chromosome 8 at 110,109,416 bp
  • T to C, chromosome 8 at 117,080,786 bp
  • C to T, chromosome 8 at 119,936,550 bp
  • C to A, chromosome 9 at 106,719,119 bp
  • T to A, chromosome 9 at 108,295,107 bp
  • T to C, chromosome 9 at 109,027,608 bp
  • T to C, chromosome 10 at 58,538,280 bp
  • T to A, chromosome 11 at 4,239,936 bp
  • C to A, chromosome 11 at 53,479,355 bp
  • G to C, chromosome 11 at 75,446,002 bp
  • A to T, chromosome 11 at 94,465,930 bp
  • A to G, chromosome 11 at 100,483,782 bp
  • A to G, chromosome 11 at 101,442,406 bp
  • T to C, chromosome 12 at 71,117,539 bp
  • T to G, chromosome 13 at 34,894,472 bp
  • T to C, chromosome 13 at 55,105,450 bp
  • G to A, chromosome 13 at 55,352,949 bp
  • C to T, chromosome 13 at 67,542,239 bp
  • G to T, chromosome 13 at 75,910,887 bp
  • A to G, chromosome 13 at 92,354,822 bp
  • T to A, chromosome 14 at 32,388,312 bp
  • T to A, chromosome 14 at 47,016,683 bp
  • T to C, chromosome 14 at 69,705,552 bp
  • C to T, chromosome 15 at 11,036,777 bp
  • C to A, chromosome 15 at 76,005,167 bp
  • T to C, chromosome 16 at 92,320,987 bp
  • T to C, chromosome 17 at 23,755,675 bp
  • T to C, chromosome 17 at 78,831,434 bp
  • G to T, chromosome 18 at 44,833,122 bp
  • T to C, chromosome 18 at 62,951,845 bp
  • A to T, chromosome 19 at 53,641,895 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7148 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045225-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.