Strain Name:
C57BL/6J-MtgxR7166Btlr/Mmmh
Stock Number:
045227-MU
Citation ID:
RRID:MMRRC_045227-MU
Other Names:
R7166 (G1)
Major Collection:

Strain Information

Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: D16Jhu34, 410I21.SP6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Atxn2
Name: ataxin 2
Synonyms: ATX2, Sca2, 9630045M23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20239
Homologene: 2234
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Npnt
Name: nephronectin
Synonyms: 1110009H02Rik, POEM
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Ambn
Name: ameloblastin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11698
HGNC: HGNC:452
Homologene: 7625
Gm4924
Name: predicted gene 4924
Synonyms: mIF1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237412
Zfp960
Name: zinc finger protein 960
Synonyms: BC018101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 449000
Homologene: 133884
Jak3
Name: Janus kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16453
HGNC: HGNC:6193
Homologene: 181
Htt
Name: huntingtin
Synonyms: HD, IT15, C430023I11Rik, htt, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Zfp12
Name: zinc finger protein 12
Synonyms: Zfp-12, Krox-7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231866
Homologene: 65328
Zfp60
Name: zinc finger protein 60
Synonyms: 6330516O17Rik, Mfg-3, Mfg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: Farslb, Farsl, PheRS alpha, Frsb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23874
Homologene: 4160
Ercc8
Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
Synonyms: Csa, B130065P18Rik, 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, Ckn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71991
HGNC: HGNC:3439
Homologene: 62
Synj2bp
Name: synaptojanin 2 binding protein
Synonyms: D12Wsu118e, OMP25, ARIP2, activin receptor interacting protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24071
Homologene: 10161
Ropn1l
Name: ropporin 1-like
Synonyms: AKAP-associated sperm protein, ASP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 252967
VEGA: 15
Homologene: 12904
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: nha-oc, NHA2, C80638, NHE10, Nhedc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97086
Homologene: 45381
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Slc26a2
Name: solute carrier family 26 (sulfate transporter), member 2
Synonyms: Dtd, ST-OB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13521
Homologene: 73876
Or4c100
Name: olfactory receptor family 4 subfamily C member 100
Synonyms: GA_x6K02T2Q125-50012960-50013871, MOR230-5, Olfr1186
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258523
Homologene: 110555
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100559
Homologene: 137225
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Or8h8
Name: olfactory receptor family 8 subfamily H member 8
Synonyms: Olfr1098, MOR206-1, GA_x6K02T2Q125-48410458-48409511
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258842
Homologene: 37005
Or1r1
Name: olfactory receptor family 1 subfamily JRmember 1
Synonyms: MOR157-1, GA_x6K02T2P1NL-4141430-4140486, Olfr398
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258705
HGNC: HGNC:8226
Homologene: 17355
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: bv, nSR100, 1500001A10Rik, flopsy, B230202K19Rik, fp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Rnf207
Name: ring finger protein 207
Synonyms: D330010C22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433809
Homologene: 19234
Fam217a
Name: family with sequence similarity 217, member A
Synonyms: 1700026J04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71864
VEGA: 13
Homologene: 82344
Paxx
Name: non-homologous end joining factor
Synonyms: paralog of XRCC4 and XLF, D930050G13Rik, BC029214
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227622
Homologene: 17788
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230025
Homologene: 11000
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Gm101, Pcdp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226356
Homologene: 88578
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230612
Homologene: 17081
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230376
Homologene: 9760
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13631
Homologene: 7299
Cfhr2
Name: complement factor H-related 2
Synonyms: FHR-B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545366
Homologene: 134349
Efcab11
Name: EF-hand calcium binding domain 11
Synonyms: 2610021K21Rik, 2610110A13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78767
VEGA: 12
Homologene: 44924
Kng1
Name: kininogen 1
Synonyms: L-kininogen, H-kininigen
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74772
Homologene: 56940
Txndc16
Name: thioredoxin domain containing 16
Synonyms: 5730420B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70561
Homologene: 18197
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231600
Homologene: 10078
Spz1
Name: spermatogenic leucine zipper 1
Synonyms: 1700027M20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 79401
VEGA: 13
Homologene: 49934
Glra1
Name: glycine receptor, alpha 1 subunit
Synonyms: B230397M16Rik, oscillator, nmf11, ot
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14654
HGNC: HGNC:4326
Homologene: 20083
Tmem169
Name: transmembrane protein 169
Synonyms: A830020B06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271711
Homologene: 16305
Gm12258
Name: predicted gene 12258
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108167848
Rab2b
Name: RAB2B, member RAS oncogene family
Synonyms: D530043M21Rik, 4930528G15Rik, 1500012D09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76338
Homologene: 23789
H4c11
Name: H4 clustered histone 11
Synonyms: Hist1h4j
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319159
Homologene: 134474
Gm14305
Name: predicted gene 14305
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043387
Homologene: 134324
Eif4a3l2
Name: eukaryotic translation initiation factor 4A3 like 2
Synonyms: Gm5580
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434080
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 72,301,070 bp
  • T to C, chromosome 1 at 78,471,184 bp
  • A to G, chromosome 1 at 119,948,113 bp
  • A to T, chromosome 1 at 139,831,101 bp
  • A to T, chromosome 2 at 25,460,226 bp
  • T to A, chromosome 2 at 76,888,028 bp
  • T to A, chromosome 2 at 86,922,748 bp
  • A to T, chromosome 2 at 88,525,646 bp
  • T to G, chromosome 2 at 112,875,028 bp
  • T to A, chromosome 2 at 176,720,943 bp
  • A to G, chromosome 3 at 132,948,128 bp
  • T to C, chromosome 3 at 135,326,178 bp
  • C to T, chromosome 4 at 21,683,528 bp
  • T to A, chromosome 4 at 32,746,446 bp
  • T to C, chromosome 4 at 86,583,687 bp
  • T to C, chromosome 4 at 111,883,839 bp
  • G to A, chromosome 4 at 134,060,882 bp
  • G to A, chromosome 4 at 141,006,984 bp
  • A to G, chromosome 4 at 152,311,780 bp
  • C to A, chromosome 5 at 34,852,894 bp
  • T to C, chromosome 5 at 87,410,446 bp
  • T to C, chromosome 5 at 88,467,528 bp
  • C to A, chromosome 5 at 110,158,805 bp
  • T to A, chromosome 5 at 116,471,242 bp
  • T to A, chromosome 5 at 121,796,397 bp
  • T to A, chromosome 5 at 143,245,502 bp
  • G to A, chromosome 6 at 108,378,190 bp
  • A to G, chromosome 6 at 116,551,368 bp
  • A to G, chromosome 7 at 27,749,512 bp
  • T to C, chromosome 7 at 120,884,772 bp
  • C to A, chromosome 8 at 25,827,320 bp
  • T to A, chromosome 8 at 69,799,316 bp
  • T to C, chromosome 8 at 71,682,316 bp
  • T to C, chromosome 9 at 70,584,850 bp
  • G to T, chromosome 9 at 108,842,951 bp
  • A to T, chromosome 10 at 78,812,812 bp
  • A to T, chromosome 10 at 82,378,201 bp
  • A to G, chromosome 11 at 55,515,078 bp
  • T to A, chromosome 11 at 58,858,473 bp
  • A to T, chromosome 11 at 73,984,295 bp
  • T to C, chromosome 12 at 81,504,515 bp
  • A to T, chromosome 12 at 99,883,355 bp
  • A to G, chromosome 13 at 21,735,151 bp
  • T to C, chromosome 13 at 34,910,315 bp
  • A to G, chromosome 13 at 92,575,927 bp
  • T to A, chromosome 13 at 108,169,433 bp
  • T to G, chromosome 14 at 45,183,154 bp
  • C to A, chromosome 14 at 52,279,345 bp
  • T to C, chromosome 15 at 31,453,509 bp
  • A to G, chromosome 15 at 37,976,145 bp
  • T to A, chromosome 16 at 23,079,678 bp
  • C to T, chromosome 16 at 94,262,726 bp
  • T to A, chromosome 17 at 17,088,499 bp
  • A to T, chromosome 18 at 61,198,829 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7166 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045227-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.