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Strain Name:
C57BL/6J-MtgxR7074Btlr/Mmmh
Stock Number:
045242-MU
Citation ID:
RRID:MMRRC_045242-MU
Other Names:
R7074 (G1)
Major Collection:

Strain Information

Prkar2b
Name: protein kinase, cAMP dependent regulatory, type II beta
Synonyms: Pkarb2, RII(beta), PKARIIbeta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19088
HGNC: HGNC:9392
Homologene: 37666
Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Fubp3
Name: far upstream element (FUSE) binding protein 3
Synonyms: FBP3, A330051M14Rik, Marta2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320267
HGNC: HGNC:4005
Homologene: 45954
Smyd1
Name: SET and MYND domain containing 1
Synonyms: Bop, 4632404M21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12180
Homologene: 7645
Zc3h14
Name: zinc finger CCCH type containing 14
Synonyms: 1700016A15Rik, 1010001P15Rik, 2700069A02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75553
VEGA: 12
Homologene: 32605
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Apc1, 2610021O03Rik, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, Astrin, s17, S17, Mastrin, Deepest, D11Bhm180e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Cep72
Name: centrosomal protein 72
Synonyms: 2610029E11Rik, 4933440J22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74470
VEGA: 13
Homologene: 10027
Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Synonyms: 5-HT7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15566
HGNC: HGNC:5302
Homologene: 20244
Ell2
Name: elongation factor for RNA polymerase II 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 192657
VEGA: 13
Homologene: 8094
Ghr
Name: growth hormone receptor
Synonyms: GHBP, GHR/BP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109254
Homologene: 13107
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Faap24
Name: Fanconi anemia core complex associated protein 24
Synonyms: C230052I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101831
Homologene: 17535
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435815
Homologene: 82530
Gas2l2
Name: growth arrest-specific 2 like 2
Synonyms: OTTMUSG00000000934
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237891
Homologene: 16409
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, CTIP2, B630002E05Rik, Rit1, 9130430L19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 58208
Homologene: 10974
Psd2
Name: pleckstrin and Sec7 domain containing 2
Synonyms: 6330404E20Rik, EFA6C
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74002
Homologene: 12522
Lao1
Name: L-amino acid oxidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100470
Homologene: 44223
Or2b11
Name: olfactory receptor family 2 subfamily B member 11
Synonyms: GA_x6K02SYYHDF-1415-2371, MOR256-45P, Olfr222
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257962
Homologene: 71979
Or52b1
Name: olfactory receptor family 52 subfamily B member 1
Synonyms: GA_x6K02T2PBJ9-7959171-7958224, MOR31-2, Olfr690
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56860
Homologene: 10653
Hmgcl
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15356
HGNC: HGNC:5005
Homologene: 159
Dixdc1
Name: DIX domain containing 1
Synonyms: 4930563F16Rik, Ccd1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330938
Homologene: 82369
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
Grip2
Name: glutamate receptor interacting protein 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243547
Homologene: 16327
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228684
Homologene: 16802
Zmym5
Name: zinc finger, MYM-type 5
Synonyms: 9830124H08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219105
Homologene: 16997
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Taz83, tMDC, Cyrn1, ADAM3, Taz83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Or2l13b
Name: olfactory receptor family 2 subfamily L member 13B
Synonyms: GA_x54KRFPKG5P-15979009-15978071, MOR271-1, Olfr168
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258354
Homologene: 128057
Gnas
Name: GNAS complex locus
Synonyms: Gnas1, Gs-alpha, Gs alpha, G alpha s, Nesp55, P2, P3, P1, neuroendocrine-specific Golgi protein p55 isoform 1, XLalphas, Gsa, Nesp, Gnasxl, Nespl, Oedsml, Galphas, SCG6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Cope
Name: coatomer protein complex, subunit epsilon
Synonyms: Cope1, 1110005D17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 59042
HGNC: HGNC:2234
Homologene: 5254
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: mGK-27, Klk27, Klk21l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16619
Homologene: 68141
Lrwd1
Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: 1200011O22Rik, Orca
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71735
Homologene: 17678
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: acetyl-CoA synthetase 1, ACAS, AceCS1, Acas1, Acs1, Acas2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Gm4950
Name: predicted pseudogene 4950
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240289
VEGA: 18
Cplx1
Name: complexin 1
Synonyms: 921-S
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12889
HGNC: HGNC:2309
Homologene: 21324
Or14j6
Name: olfactory receptor family 14 subfamily J member 6
Synonyms: MOR218-7, GA_x6K02T2PSCP-2354126-2355093, Olfr127
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258374
Homologene: 134080
Ankrd33
Name: ankyrin repeat domain 33
Synonyms: A930021G21Rik, Panky
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 208258
VEGA: 15
Homologene: 16992
Gm826
Name: predicted gene 826
Synonyms: LOC329554, Gm46773
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329554
Trem3
Name: triggering receptor expressed on myeloid cells 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58218
VEGA: 17
Homologene: 87012
Vmn1r51
Name: vomeronasal 1 receptor 51
Synonyms: V1r1, VN12, V1ra1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22296
Homologene: 130651
Or1e1b-ps1
Name: olfactory receptor family 1 subfamily E member 1B, pseudogene 1
Synonyms: MTPCR35, MOR135-18, GA_x6K02T2P1NL-4111497-4112433, Olfr22-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 31,595,294 bp
  • G to A, chromosome 2 at 76,918,081 bp
  • G to T, chromosome 2 at 128,678,274 bp
  • C to T, chromosome 2 at 131,522,111 bp
  • T to A, chromosome 2 at 140,263,442 bp
  • T to C, chromosome 2 at 155,522,041 bp
  • C to T, chromosome 2 at 160,311,890 bp
  • G to A, chromosome 2 at 174,285,049 bp
  • C to A, chromosome 3 at 138,107,273 bp
  • T to C, chromosome 4 at 11,204,574 bp
  • A to T, chromosome 4 at 98,945,208 bp
  • A to C, chromosome 4 at 118,968,185 bp
  • A to G, chromosome 4 at 135,953,867 bp
  • A to T, chromosome 4 at 144,613,863 bp
  • C to T, chromosome 5 at 108,548,527 bp
  • T to A, chromosome 5 at 125,049,366 bp
  • C to T, chromosome 5 at 136,123,657 bp
  • A to G, chromosome 6 at 71,237,375 bp
  • A to T, chromosome 6 at 90,129,672 bp
  • A to T, chromosome 6 at 91,784,708 bp
  • A to T, chromosome 7 at 35,395,102 bp
  • G to A, chromosome 7 at 44,056,553 bp
  • A to G, chromosome 7 at 105,329,268 bp
  • A to T, chromosome 8 at 24,694,347 bp
  • A to G, chromosome 8 at 70,312,887 bp
  • G to A, chromosome 8 at 87,782,432 bp
  • T to C, chromosome 9 at 18,655,650 bp
  • T to A, chromosome 9 at 50,689,914 bp
  • T to C, chromosome 11 at 59,571,009 bp
  • A to T, chromosome 11 at 73,955,149 bp
  • T to A, chromosome 11 at 76,813,594 bp
  • T to A, chromosome 11 at 77,842,561 bp
  • T to C, chromosome 11 at 78,305,042 bp
  • T to A, chromosome 11 at 83,423,067 bp
  • T to C, chromosome 11 at 120,903,374 bp
  • A to G, chromosome 12 at 31,972,148 bp
  • A to G, chromosome 12 at 98,758,600 bp
  • A to G, chromosome 12 at 107,989,507 bp
  • A to T, chromosome 13 at 41,828,141 bp
  • A to G, chromosome 13 at 74,051,580 bp
  • C to A, chromosome 13 at 75,761,887 bp
  • A to T, chromosome 13 at 93,453,931 bp
  • T to C, chromosome 14 at 56,804,798 bp
  • A to T, chromosome 15 at 3,333,391 bp
  • A to G, chromosome 15 at 89,120,636 bp
  • A to G, chromosome 15 at 101,119,549 bp
  • T to A, chromosome 16 at 19,530,105 bp
  • T to A, chromosome 17 at 12,714,116 bp
  • T to A, chromosome 17 at 37,903,827 bp
  • C to T, chromosome 17 at 48,249,881 bp
  • T to A, chromosome 17 at 78,974,807 bp
  • A to G, chromosome 18 at 36,010,684 bp
  • G to A, chromosome 18 at 51,865,449 bp
  • T to A, chromosome 18 at 54,897,382 bp
  • A to G, chromosome 19 at 36,056,883 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7074 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045242-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.