Strain Name:
C57BL/6J-MtgxR7137Btlr/Mmmh
Stock Number:
045248-MU
Citation ID:
RRID:MMRRC_045248-MU
Other Names:
R7137 (G1)
Major Collection:

Strain Information

Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: FRNK, Fadk, FAK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Acvr1c
Name: activin A receptor, type IC
Synonyms: ALK7, Alk-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269275
Homologene: 26724
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, Prkwnk1, 6430573H23Rik, EG406236
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Plcg1
Name: phospholipase C, gamma 1
Synonyms: Plc-gamma1, Cded, Plc-1, Plcg-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18803
HGNC: HGNC:9065
Homologene: 1997
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Zbtb45
Name: zinc finger and BTB domain containing 45
Synonyms: LOC232879, Zfp499
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232879
Homologene: 13118
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: TEG-190, 9430095H01Rik, Tex190
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Tln1
Name: talin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21894
Homologene: 21267
Wrnip1
Name: Werner helicase interacting protein 1
Synonyms: 4833444L21Rik, WHIP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78903
Homologene: 10592
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: M100174, Nmdar, Rgsc174, NR1, NMDAR1, GluRzeta1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Nfkbid
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
Synonyms: IkappaBNS
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243910
Homologene: 13101
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Insc
Name: INSC spindle orientation adaptor protein
Synonyms: 3830422K02Rik, Inscuteable
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233752
Homologene: 78662
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Vmn1r76
Name: vomeronasal 1 receptor 76
Synonyms: V1rg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171239
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Psma1
Name: proteasome subunit alpha 1
Synonyms: HC2, C2, Pros-30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26440
HGNC: HGNC:9530
Homologene: 2080
Emcn
Name: endomucin
Synonyms: 0610012K22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59308
Homologene: 9438
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: MX, 4931438M07Rik, alpha mannosidase IIx, 1700052O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: NAALADASE2, GCPIII, D9Ertd285e, GCP3, NAADALASE2, Folh1b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72560
Homologene: 3294
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-1, Es-N, Es-4, Ee-1, Ces-N, Es1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Tor1aip2
Name: torsin A interacting protein 2
Synonyms: LULL1, 15kDa, 1110020D10Rik, Ifrg15
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240832
Homologene: 17028
Mcur1
Name: mitochondrial calcium uniporter regulator 1
Synonyms: Ccdc90a, 6230416A05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76137
VEGA: 13
Homologene: 134447
Fsd1
Name: fibronectin type 3 and SPRY domain-containing protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240121
VEGA: 17
Homologene: 11531
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Fibin
Name: fin bud initiation factor homolog (zebrafish)
Synonyms: 1110018M03Rik, Fibin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67606
Homologene: 12163
Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Synonyms: Orct2, Oct2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20518
VEGA: 17
Homologene: 68293
Zar1
Name: zygote arrest 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 317755
Homologene: 18370
Sult1c2
Name: sulfotransferase family, cytosolic, 1C, member 2
Synonyms: 1810008N17Rik, ST1C1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69083
Homologene: 38201
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104816
VEGA: 12
Homologene: 113390
Bcl2a1d
Name: B cell leukemia/lymphoma 2 related protein A1d
Synonyms: A1-d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12047
HGNC: HGNC:991
Homologene: 2988
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: LOC243374, IAN9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243374
Homologene: 69703
Syt12
Name: synaptotagmin XII
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171180
Homologene: 15895
Slc25a2
Name: solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
Synonyms: Ornt2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83885
Homologene: 129775
Gm20481
Name: predicted gene 20481
Type: Gene
Species: Mouse
Chromosome: 17
Eif1ad19
Name: eukaryotic translation initiation factor 1A domain containing 19
Synonyms: Gm21319
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100861908
Homologene: 103865
Pyy
Name: peptide YY
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217212
Homologene: 3066
Ighv8-13
Name: immunoglobulin heavy variable 8-13
Synonyms: Gm16810
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100775172
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 116,089,376 bp
  • T to A, chromosome 1 at 156,051,976 bp
  • T to G, chromosome 2 at 25,313,538 bp
  • A to G, chromosome 2 at 58,283,387 bp
  • T to A, chromosome 2 at 110,362,656 bp
  • T to C, chromosome 2 at 160,753,926 bp
  • A to C, chromosome 3 at 59,258,254 bp
  • T to G, chromosome 3 at 137,403,991 bp
  • C to T, chromosome 4 at 43,540,616 bp
  • T to A, chromosome 5 at 72,580,816 bp
  • A to G, chromosome 6 at 32,517,264 bp
  • C to A, chromosome 6 at 48,650,253 bp
  • A to G, chromosome 6 at 48,990,149 bp
  • C to A, chromosome 6 at 120,038,212 bp
  • T to C, chromosome 6 at 121,677,985 bp
  • A to T, chromosome 6 at 141,498,746 bp
  • A to G, chromosome 7 at 11,930,685 bp
  • T to C, chromosome 7 at 13,007,156 bp
  • A to G, chromosome 7 at 30,426,256 bp
  • A to G, chromosome 7 at 66,285,279 bp
  • C to A, chromosome 7 at 80,359,751 bp
  • C to A, chromosome 7 at 104,841,591 bp
  • A to G, chromosome 7 at 114,274,448 bp
  • G to A, chromosome 7 at 114,811,615 bp
  • T to C, chromosome 8 at 93,130,842 bp
  • A to T, chromosome 9 at 15,997,148 bp
  • T to C, chromosome 9 at 18,323,487 bp
  • T to G, chromosome 9 at 32,151,936 bp
  • T to C, chromosome 9 at 88,731,478 bp
  • T to C, chromosome 9 at 122,854,778 bp
  • C to T, chromosome 11 at 69,491,555 bp
  • T to G, chromosome 11 at 102,107,273 bp
  • A to T, chromosome 12 at 87,773,546 bp
  • T to C, chromosome 12 at 112,112,198 bp
  • T to C, chromosome 12 at 112,735,167 bp
  • A to G, chromosome 12 at 115,765,577 bp
  • A to G, chromosome 13 at 32,802,749 bp
  • C to A, chromosome 13 at 43,544,455 bp
  • A to G, chromosome 14 at 84,533,549 bp
  • A to T, chromosome 14 at 103,282,679 bp
  • G to A, chromosome 15 at 73,221,809 bp
  • C to T, chromosome 15 at 82,557,821 bp
  • A to G, chromosome 16 at 20,652,627 bp
  • A to G, chromosome 17 at 12,584,341 bp
  • A to G, chromosome 17 at 34,970,095 bp
  • A to G, chromosome 17 at 43,450,897 bp
  • A to C, chromosome 17 at 53,838,394 bp
  • G to A, chromosome 17 at 55,993,876 bp
  • C to A, chromosome 18 at 3,273,459 bp
  • T to C, chromosome 18 at 37,267,392 bp
  • T to C, chromosome 18 at 37,638,147 bp
  • C to T, chromosome 19 at 4,453,950 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7137 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045248-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.