Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7156Btlr/Mmmh
Stock Number:
045257-MU
Citation ID:
RRID:MMRRC_045257-MU
Other Names:
R7156 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Steel Factor Receptor, c-KIT, Dominant white spotting, belly-spot, Tr-kit, SOW3, SCO5, SCO1, Gsfsow3, Gsfsco5, Gsfsco1, CD117
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Matr3
Name: matrin 3
Synonyms: D030046F20Rik, 2810017I02Rik, 1110061A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Pax2
Name: paired box 2
Synonyms: Pax-2, Opdc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18504
HGNC: HGNC:8616
Homologene: 2968
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Snx17
Name: sorting nexin 17
Synonyms: 5830447M19Rik, D5Ertd260e, b2b1625.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 266781
Homologene: 8838
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 28,776,767 bp
  • G to A, chromosome 1 at 38,874,007 bp
  • G to A, chromosome 1 at 43,111,101 bp
  • G to A, chromosome 1 at 93,413,915 bp
  • A to C, chromosome 1 at 136,147,824 bp
  • G to A, chromosome 1 at 180,599,064 bp
  • T to A, chromosome 2 at 32,340,467 bp
  • C to A, chromosome 2 at 52,305,283 bp
  • T to A, chromosome 2 at 70,021,623 bp
  • A to G, chromosome 2 at 82,982,741 bp
  • T to A, chromosome 2 at 86,445,308 bp
  • C to T, chromosome 2 at 118,791,811 bp
  • T to A, chromosome 3 at 92,789,184 bp
  • T to A, chromosome 4 at 59,617,653 bp
  • T to C, chromosome 4 at 62,617,126 bp
  • A to G, chromosome 4 at 72,170,716 bp
  • T to G, chromosome 4 at 89,688,463 bp
  • A to G, chromosome 4 at 94,660,952 bp
  • G to T, chromosome 4 at 106,387,919 bp
  • A to T, chromosome 4 at 108,595,459 bp
  • A to G, chromosome 4 at 109,981,988 bp
  • T to A, chromosome 4 at 119,657,690 bp
  • T to A, chromosome 4 at 145,315,084 bp
  • C to T, chromosome 5 at 24,552,650 bp
  • T to A, chromosome 5 at 31,197,348 bp
  • C to T, chromosome 5 at 31,272,075 bp
  • G to A, chromosome 5 at 45,453,916 bp
  • G to T, chromosome 5 at 62,604,571 bp
  • A to T, chromosome 5 at 75,615,374 bp
  • A to G, chromosome 5 at 110,685,363 bp
  • T to C, chromosome 6 at 23,688,956 bp
  • T to C, chromosome 6 at 38,195,029 bp
  • T to C, chromosome 6 at 84,087,876 bp
  • C to A, chromosome 6 at 121,880,905 bp
  • C to T, chromosome 6 at 121,884,343 bp
  • C to T, chromosome 6 at 128,435,824 bp
  • T to C, chromosome 6 at 147,534,178 bp
  • A to G, chromosome 7 at 24,420,861 bp
  • G to T, chromosome 7 at 34,245,708 bp
  • T to C, chromosome 7 at 40,993,858 bp
  • T to C, chromosome 7 at 87,037,643 bp
  • T to A, chromosome 7 at 97,535,286 bp
  • G to A, chromosome 7 at 101,346,051 bp
  • C to T, chromosome 7 at 105,554,486 bp
  • C to T, chromosome 7 at 127,612,291 bp
  • C to T, chromosome 7 at 139,582,129 bp
  • C to T, chromosome 8 at 84,135,760 bp
  • T to A, chromosome 8 at 109,948,188 bp
  • T to A, chromosome 8 at 121,554,321 bp
  • T to C, chromosome 9 at 40,023,230 bp
  • T to A, chromosome 9 at 57,929,756 bp
  • T to A, chromosome 9 at 58,902,923 bp
  • T to C, chromosome 9 at 108,838,004 bp
  • T to C, chromosome 9 at 114,378,096 bp
  • T to C, chromosome 10 at 39,626,177 bp
  • T to A, chromosome 10 at 41,485,257 bp
  • T to G, chromosome 10 at 79,994,515 bp
  • A to G, chromosome 11 at 33,297,420 bp
  • A to G, chromosome 11 at 35,897,374 bp
  • A to G, chromosome 11 at 87,484,719 bp
  • A to C, chromosome 11 at 106,809,224 bp
  • A to G, chromosome 11 at 115,390,966 bp
  • T to G, chromosome 12 at 70,877,209 bp
  • T to A, chromosome 12 at 83,664,191 bp
  • A to G, chromosome 13 at 32,971,615 bp
  • G to A, chromosome 13 at 55,418,497 bp
  • A to T, chromosome 13 at 56,789,766 bp
  • A to T, chromosome 13 at 62,841,861 bp
  • G to A, chromosome 13 at 74,229,916 bp
  • A to T, chromosome 13 at 89,689,110 bp
  • C to T, chromosome 14 at 66,916,531 bp
  • T to C, chromosome 15 at 82,305,702 bp
  • G to A, chromosome 15 at 101,865,496 bp
  • G to A, chromosome 16 at 23,966,226 bp
  • T to A, chromosome 17 at 24,500,683 bp
  • T to A, chromosome 17 at 25,743,210 bp
  • G to T, chromosome 18 at 35,572,921 bp
  • A to G, chromosome 19 at 25,610,953 bp
  • A to T, chromosome 19 at 44,788,859 bp
  • G to A, chromosome 19 at 55,268,828 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7156 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045257-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.