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Strain Detail Sheet

Published:
Revised: 03/02/2024

Strain Name:
C57BL/6J-MtgxR7172Btlr/Mmmh
Stock Number:
045264-MU
Citation ID:
RRID:MMRRC_045264-MU
Other Names:
R7172 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: A230053P19Rik, D130071N24Rik, Hip14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320150
VEGA: 10
Homologene: 56324

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Arg, Abll
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Patz1
Name: POZ (BTB) and AT hook containing zinc finger 1
Synonyms: MAZR, 8430401L15Rik, POZ-AT hook-zinc finger protein, Zfp278
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56218
Homologene: 8636

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,799,134 bp
  • A to T, chromosome 1 at 97,834,478 bp
  • A to G, chromosome 1 at 150,753,699 bp
  • A to C, chromosome 1 at 153,826,220 bp
  • A to G, chromosome 1 at 156,622,587 bp
  • A to T, chromosome 1 at 160,733,586 bp
  • A to T, chromosome 1 at 171,360,660 bp
  • G to T, chromosome 2 at 103,732,969 bp
  • T to A, chromosome 2 at 112,661,657 bp
  • A to T, chromosome 2 at 122,638,318 bp
  • T to C, chromosome 3 at 62,501,015 bp
  • G to A, chromosome 3 at 89,432,636 bp
  • C to T, chromosome 3 at 96,880,069 bp
  • C to T, chromosome 3 at 122,103,540 bp
  • A to T, chromosome 3 at 130,570,332 bp
  • A to G, chromosome 4 at 56,903,946 bp
  • A to T, chromosome 4 at 59,315,420 bp
  • A to T, chromosome 4 at 60,222,425 bp
  • A to G, chromosome 4 at 101,836,996 bp
  • G to T, chromosome 4 at 128,585,676 bp
  • T to G, chromosome 4 at 146,122,002 bp
  • A to G, chromosome 5 at 5,682,896 bp
  • A to T, chromosome 5 at 8,702,399 bp
  • G to T, chromosome 5 at 34,234,409 bp
  • G to A, chromosome 5 at 89,883,001 bp
  • A to G, chromosome 5 at 90,904,020 bp
  • G to A, chromosome 5 at 124,062,806 bp
  • A to G, chromosome 6 at 52,204,296 bp
  • A to C, chromosome 6 at 90,107,404 bp
  • T to C, chromosome 7 at 25,343,667 bp
  • G to T, chromosome 7 at 25,786,974 bp
  • A to T, chromosome 7 at 43,999,247 bp
  • A to G, chromosome 7 at 141,213,641 bp
  • A to G, chromosome 7 at 141,271,928 bp
  • G to T, chromosome 7 at 144,582,171 bp
  • G to A, chromosome 8 at 13,974,579 bp
  • G to T, chromosome 8 at 71,388,766 bp
  • A to G, chromosome 8 at 83,254,761 bp
  • A to G, chromosome 8 at 85,079,824 bp
  • A to G, chromosome 8 at 86,860,424 bp
  • G to T, chromosome 8 at 116,956,542 bp
  • C to A, chromosome 9 at 22,105,494 bp
  • T to A, chromosome 9 at 57,248,335 bp
  • G to T, chromosome 9 at 108,560,610 bp
  • G to A, chromosome 10 at 74,502,765 bp
  • A to G, chromosome 10 at 111,009,948 bp
  • T to G, chromosome 10 at 127,888,349 bp
  • T to G, chromosome 11 at 3,308,032 bp
  • T to A, chromosome 11 at 58,489,745 bp
  • A to T, chromosome 11 at 67,188,701 bp
  • A to T, chromosome 11 at 68,385,667 bp
  • C to T, chromosome 11 at 69,916,436 bp
  • T to C, chromosome 11 at 77,515,296 bp
  • C to T, chromosome 11 at 80,592,795 bp
  • T to C, chromosome 11 at 106,020,274 bp
  • T to A, chromosome 11 at 118,041,131 bp
  • G to A, chromosome 12 at 57,325,535 bp
  • A to G, chromosome 12 at 65,106,054 bp
  • C to G, chromosome 13 at 41,316,804 bp
  • C to T, chromosome 13 at 67,670,408 bp
  • T to A, chromosome 14 at 4,777,282 bp
  • A to T, chromosome 14 at 23,526,623 bp
  • G to A, chromosome 14 at 34,237,568 bp
  • A to G, chromosome 14 at 54,514,886 bp
  • G to T, chromosome 16 at 3,963,753 bp
  • G to A, chromosome 16 at 4,613,475 bp
  • A to C, chromosome 17 at 9,422,388 bp
  • A to T, chromosome 17 at 23,644,788 bp
  • A to G, chromosome 17 at 34,696,020 bp
  • A to G, chromosome 17 at 36,870,063 bp
  • A to G, chromosome 17 at 67,804,545 bp
  • T to C, chromosome 18 at 25,085,546 bp
  • T to C, chromosome 18 at 71,378,684 bp
  • A to G, chromosome 19 at 6,939,681 bp
  • G to T, chromosome 19 at 34,573,494 bp
  • A to G, chromosome 19 at 41,634,666 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7172 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045264-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.