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Strain Name:
C57BL/6J-MtgxR7199Btlr/Mmmh
Stock Number:
045277-MU
Citation ID:
RRID:MMRRC_045277-MU
Other Names:
R7199 (G1)
Major Collection:

Strain Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: RII(alpha), 1110061A24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: A930006P13Rik, Pcaf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,347,290 bp
  • G to T, chromosome 1 at 45,332,141 bp
  • T to A, chromosome 1 at 53,256,730 bp
  • G to T, chromosome 1 at 74,383,671 bp
  • A to T, chromosome 1 at 93,402,978 bp
  • G to A, chromosome 1 at 156,301,723 bp
  • A to T, chromosome 1 at 174,223,271 bp
  • T to A, chromosome 1 at 192,337,605 bp
  • T to A, chromosome 1 at 195,117,570 bp
  • T to C, chromosome 2 at 13,656,910 bp
  • A to T, chromosome 2 at 26,952,714 bp
  • A to T, chromosome 2 at 36,452,860 bp
  • G to A, chromosome 2 at 52,220,200 bp
  • C to A, chromosome 2 at 103,439,296 bp
  • T to C, chromosome 2 at 103,567,220 bp
  • T to C, chromosome 2 at 111,621,193 bp
  • A to T, chromosome 2 at 119,216,637 bp
  • A to G, chromosome 2 at 129,038,318 bp
  • T to C, chromosome 2 at 129,285,055 bp
  • C to A, chromosome 3 at 18,055,842 bp
  • A to C, chromosome 3 at 38,977,362 bp
  • T to C, chromosome 3 at 52,983,189 bp
  • T to C, chromosome 3 at 87,083,388 bp
  • T to A, chromosome 3 at 87,743,077 bp
  • G to A, chromosome 3 at 94,944,434 bp
  • T to C, chromosome 3 at 95,680,809 bp
  • A to G, chromosome 3 at 131,585,138 bp
  • T to A, chromosome 4 at 56,972,282 bp
  • A to T, chromosome 4 at 66,841,193 bp
  • A to G, chromosome 4 at 81,297,333 bp
  • T to C, chromosome 4 at 124,857,190 bp
  • C to T, chromosome 4 at 126,275,152 bp
  • G to A, chromosome 4 at 133,064,624 bp
  • A to T, chromosome 5 at 30,783,195 bp
  • T to C, chromosome 5 at 99,300,039 bp
  • A to T, chromosome 5 at 112,331,178 bp
  • A to G, chromosome 5 at 137,290,242 bp
  • G to A, chromosome 6 at 32,215,178 bp
  • T to A, chromosome 6 at 41,462,756 bp
  • T to C, chromosome 6 at 41,543,242 bp
  • T to G, chromosome 6 at 113,121,138 bp
  • T to C, chromosome 6 at 113,673,084 bp
  • A to T, chromosome 7 at 5,017,884 bp
  • G to A, chromosome 7 at 6,677,873 bp
  • A to T, chromosome 7 at 16,273,154 bp
  • T to C, chromosome 7 at 44,353,140 bp
  • T to C, chromosome 7 at 45,084,909 bp
  • G to A, chromosome 7 at 131,235,912 bp
  • T to C, chromosome 8 at 85,302,961 bp
  • T to C, chromosome 8 at 106,689,159 bp
  • A to G, chromosome 9 at 39,839,457 bp
  • T to A, chromosome 9 at 55,838,176 bp
  • C to A, chromosome 9 at 78,433,033 bp
  • T to C, chromosome 9 at 108,115,334 bp
  • C to A, chromosome 9 at 108,740,470 bp
  • T to A, chromosome 10 at 18,129,146 bp
  • T to C, chromosome 10 at 39,080,540 bp
  • T to G, chromosome 10 at 107,874,533 bp
  • T to A, chromosome 10 at 127,573,456 bp
  • A to T, chromosome 11 at 36,171,436 bp
  • T to A, chromosome 11 at 51,007,396 bp
  • T to A, chromosome 11 at 54,546,426 bp
  • G to A, chromosome 11 at 59,012,846 bp
  • T to C, chromosome 11 at 66,118,944 bp
  • C to A, chromosome 11 at 72,303,375 bp
  • T to A, chromosome 11 at 78,154,857 bp
  • G to C, chromosome 11 at 80,246,734 bp
  • T to A, chromosome 11 at 105,390,706 bp
  • T to A, chromosome 11 at 120,730,261 bp
  • T to A, chromosome 12 at 5,017,992 bp
  • A to T, chromosome 12 at 8,005,072 bp
  • A to G, chromosome 12 at 30,588,655 bp
  • G to A, chromosome 12 at 36,130,055 bp
  • A to G, chromosome 12 at 64,995,518 bp
  • T to A, chromosome 13 at 22,883,561 bp
  • T to C, chromosome 13 at 60,754,210 bp
  • A to T, chromosome 13 at 62,777,063 bp
  • T to C, chromosome 13 at 74,666,139 bp
  • G to A, chromosome 14 at 54,573,458 bp
  • G to A, chromosome 14 at 55,548,712 bp
  • G to T, chromosome 15 at 4,994,243 bp
  • A to G, chromosome 15 at 76,071,868 bp
  • A to G, chromosome 16 at 13,147,793 bp
  • A to G, chromosome 16 at 26,371,596 bp
  • A to G, chromosome 16 at 88,759,014 bp
  • G to A, chromosome 17 at 24,377,707 bp
  • A to G, chromosome 17 at 29,676,200 bp
  • A to C, chromosome 17 at 37,952,157 bp
  • T to C, chromosome 17 at 53,670,678 bp
  • T to A, chromosome 17 at 66,340,539 bp
  • T to C, chromosome 18 at 5,767,703 bp
  • G to T, chromosome 18 at 58,053,761 bp
  • T to C, chromosome 18 at 65,994,865 bp
  • A to T, chromosome 18 at 74,955,584 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7199 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045277-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.