Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7202Btlr/Mmmh
Stock Number:
045280-MU
Citation ID:
RRID:MMRRC_045280-MU
Other Names:
R7202 (G1)
Major Collection:

Strain Information

Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Abtb3
Name: ankyrin repeat and BTB domain containing 3
Synonyms: 6330404E16Rik, Btbd11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74007
Homologene: 72536
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 52,853,715 bp
  • T to A, chromosome 1 at 75,489,716 bp
  • A to T, chromosome 1 at 131,762,788 bp
  • T to G, chromosome 1 at 134,624,759 bp
  • A to G, chromosome 1 at 156,079,088 bp
  • A to T, chromosome 1 at 167,226,515 bp
  • A to G, chromosome 2 at 25,214,574 bp
  • G to T, chromosome 2 at 27,952,378 bp
  • G to A, chromosome 2 at 112,766,319 bp
  • A to T, chromosome 2 at 119,374,437 bp
  • A to T, chromosome 2 at 119,658,426 bp
  • A to T, chromosome 3 at 75,333,273 bp
  • A to T, chromosome 3 at 84,175,034 bp
  • G to T, chromosome 3 at 94,958,961 bp
  • T to A, chromosome 3 at 123,671,739 bp
  • T to C, chromosome 4 at 41,498,268 bp
  • G to T, chromosome 4 at 44,351,106 bp
  • T to A, chromosome 4 at 109,244,057 bp
  • C to T, chromosome 4 at 118,934,018 bp
  • T to A, chromosome 4 at 133,061,887 bp
  • G to T, chromosome 4 at 155,426,197 bp
  • A to T, chromosome 5 at 23,492,294 bp
  • T to A, chromosome 5 at 30,204,380 bp
  • A to T, chromosome 5 at 104,302,161 bp
  • A to G, chromosome 5 at 110,297,107 bp
  • A to G, chromosome 5 at 150,532,354 bp
  • G to A, chromosome 6 at 48,412,327 bp
  • A to G, chromosome 6 at 73,181,705 bp
  • A to T, chromosome 6 at 115,730,459 bp
  • A to G, chromosome 6 at 120,475,611 bp
  • C to T, chromosome 7 at 13,291,249 bp
  • A to G, chromosome 7 at 34,132,662 bp
  • T to C, chromosome 7 at 45,178,172 bp
  • C to T, chromosome 7 at 46,288,050 bp
  • T to C, chromosome 7 at 56,131,286 bp
  • T to C, chromosome 7 at 62,348,961 bp
  • T to A, chromosome 7 at 103,443,085 bp
  • A to G, chromosome 7 at 107,074,241 bp
  • T to A, chromosome 7 at 118,639,956 bp
  • T to C, chromosome 7 at 120,318,013 bp
  • G to T, chromosome 7 at 127,476,476 bp
  • AGGCGCAGAAACCCTGGC to AGGC, chromosome 7 at 141,634,450 bp
  • T to G, chromosome 8 at 25,919,581 bp
  • T to C, chromosome 8 at 93,302,967 bp
  • T to C, chromosome 8 at 104,523,583 bp
  • C to T, chromosome 8 at 104,614,148 bp
  • T to C, chromosome 9 at 44,847,715 bp
  • C to T, chromosome 9 at 70,410,846 bp
  • T to C, chromosome 9 at 75,683,710 bp
  • T to G, chromosome 9 at 86,504,167 bp
  • T to G, chromosome 9 at 90,017,072 bp
  • A to G, chromosome 9 at 110,867,564 bp
  • A to G, chromosome 10 at 85,387,765 bp
  • T to C, chromosome 10 at 111,491,103 bp
  • A to G, chromosome 10 at 128,118,559 bp
  • A to G, chromosome 11 at 78,500,800 bp
  • T to C, chromosome 11 at 80,089,775 bp
  • C to T, chromosome 11 at 97,451,993 bp
  • T to C, chromosome 12 at 31,324,315 bp
  • G to A, chromosome 13 at 67,343,642 bp
  • A to T, chromosome 13 at 106,875,570 bp
  • C to A, chromosome 14 at 14,836,171 bp
  • G to A, chromosome 14 at 26,778,912 bp
  • C to A, chromosome 14 at 26,900,437 bp
  • A to G, chromosome 15 at 82,092,642 bp
  • T to C, chromosome 16 at 18,405,198 bp
  • T to A, chromosome 16 at 23,127,609 bp
  • T to C, chromosome 16 at 38,335,597 bp
  • C to A, chromosome 16 at 44,059,221 bp
  • T to A, chromosome 17 at 26,974,692 bp
  • T to A, chromosome 18 at 31,956,964 bp
  • C to T, chromosome 18 at 56,776,089 bp
  • A to T, chromosome 19 at 4,602,333 bp
  • A to T, chromosome 19 at 9,017,799 bp
  • A to T, chromosome 19 at 39,141,904 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7202 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045280-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.