Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7220Btlr/Mmmh
Stock Number:
045292-MU
Citation ID:
RRID:MMRRC_045292-MU
Other Names:
R7220 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Atl3
Name: atlastin GTPase 3
Synonyms: 4633402C03Rik, 5730596K20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: RPTRalpha, PTPalpha, PTP[a], Ptpa, RPTPalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Ociad1
Name: OCIA domain containing 1
Synonyms: expressed during mesenchymal induction 2, Emi2, B230209J16Rik, 6030432N09Rik, TPA018, Asrij, Imi2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68095
Homologene: 9866
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,523,126 bp
  • C to A, chromosome 1 at 55,238,063 bp
  • C to T, chromosome 1 at 135,313,575 bp
  • A to G, chromosome 1 at 173,270,244 bp
  • A to G, chromosome 2 at 69,749,976 bp
  • T to C, chromosome 2 at 121,358,893 bp
  • C to T, chromosome 2 at 129,275,516 bp
  • T to A, chromosome 2 at 130,544,497 bp
  • T to C, chromosome 3 at 103,326,793 bp
  • G to A, chromosome 3 at 113,628,355 bp
  • C to A, chromosome 3 at 116,880,776 bp
  • A to T, chromosome 4 at 66,839,951 bp
  • G to C, chromosome 4 at 94,804,304 bp
  • A to G, chromosome 4 at 101,837,368 bp
  • A to G, chromosome 4 at 112,728,973 bp
  • A to G, chromosome 4 at 155,754,041 bp
  • A to G, chromosome 5 at 25,344,925 bp
  • A to G, chromosome 5 at 73,313,466 bp
  • T to C, chromosome 5 at 76,901,925 bp
  • A to G, chromosome 5 at 109,360,906 bp
  • A to T, chromosome 5 at 139,762,073 bp
  • T to A, chromosome 6 at 48,476,606 bp
  • A to T, chromosome 6 at 87,349,153 bp
  • A to G, chromosome 6 at 146,858,865 bp
  • A to G, chromosome 7 at 5,220,560 bp
  • A to G, chromosome 7 at 19,967,753 bp
  • A to G, chromosome 7 at 79,108,148 bp
  • T to C, chromosome 7 at 88,297,153 bp
  • A to G, chromosome 7 at 114,536,062 bp
  • G to A, chromosome 7 at 120,227,444 bp
  • A to T, chromosome 8 at 70,189,498 bp
  • G to T, chromosome 8 at 111,081,572 bp
  • G to A, chromosome 8 at 119,745,561 bp
  • G to T, chromosome 9 at 23,399,355 bp
  • A to T, chromosome 9 at 38,329,750 bp
  • G to T, chromosome 9 at 42,343,887 bp
  • G to T, chromosome 9 at 53,511,917 bp
  • A to C, chromosome 10 at 53,920,235 bp
  • A to T, chromosome 10 at 58,280,594 bp
  • A to T, chromosome 10 at 64,834,589 bp
  • G to A, chromosome 10 at 74,342,609 bp
  • A to C, chromosome 10 at 89,576,413 bp
  • A to G, chromosome 10 at 121,090,114 bp
  • C to A, chromosome 11 at 70,315,905 bp
  • A to T, chromosome 11 at 74,044,763 bp
  • A to G, chromosome 11 at 75,178,675 bp
  • G to T, chromosome 11 at 109,981,717 bp
  • T to A, chromosome 11 at 110,089,967 bp
  • A to G, chromosome 12 at 29,994,480 bp
  • A to T, chromosome 12 at 36,123,951 bp
  • G to A, chromosome 12 at 55,304,415 bp
  • A to T, chromosome 12 at 91,567,724 bp
  • A to G, chromosome 12 at 100,130,919 bp
  • A to G, chromosome 12 at 112,014,454 bp
  • T to C, chromosome 12 at 115,158,515 bp
  • T to C, chromosome 12 at 115,604,046 bp
  • A to T, chromosome 14 at 33,507,475 bp
  • G to T, chromosome 14 at 55,942,663 bp
  • A to T, chromosome 14 at 64,095,995 bp
  • A to G, chromosome 15 at 48,457,598 bp
  • A to T, chromosome 15 at 83,385,059 bp
  • A to T, chromosome 15 at 84,953,136 bp
  • T to A, chromosome 16 at 18,501,276 bp
  • A to G, chromosome 16 at 22,833,997 bp
  • T to A, chromosome 17 at 23,477,203 bp
  • C to T, chromosome 17 at 26,253,245 bp
  • C to A, chromosome 17 at 29,319,234 bp
  • C to A, chromosome 17 at 31,619,217 bp
  • T to A, chromosome 17 at 32,225,583 bp
  • T to C, chromosome 17 at 34,241,260 bp
  • A to T, chromosome 17 at 56,418,988 bp
  • T to C, chromosome 18 at 14,679,420 bp
  • A to G, chromosome 19 at 7,529,068 bp
  • A to T, chromosome 19 at 9,992,115 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7220 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045292-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.