Strain Name:
C57BL/6J-MtgxR7251Btlr/Mmmh
Stock Number:
045313-MU
Citation ID:
RRID:MMRRC_045313-MU
Other Names:
R7251 (G1)
Major Collection:

Strain Information

Hgf
Name: hepatocyte growth factor
Synonyms: NK2, SF/HGF, HGF/SF, C230052L06Rik, scatter factor, NK1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, 4933435E07Rik, Alpha-MPP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Mgll
Name: monoglyceride lipase
Synonyms: Magl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23945
Homologene: 38298
Stk24
Name: serine/threonine kinase 24
Synonyms: 1810013H02Rik, STE20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223255
VEGA: 14
Homologene: 20793
Agrn
Name: agrin
Synonyms: NMF380, nmf380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Ptpn2
Name: protein tyrosine phosphatase, non-receptor type 2
Synonyms: Ptpt, TC-PTP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19255
HGNC: HGNC:9650
Homologene: 7497
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75991
Homologene: 18952
Braf
Name: Braf transforming gene
Synonyms: Braf-2, Braf2, 9930012E13Rik, D6Ertd631e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109880
HGNC: HGNC:1097
Homologene: 3197
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: D730028O18Rik, D130059B05Rik, BIG1, ARFGEP1, P200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Ddx39b
Name: DEAD box helicase 39b
Synonyms: 0610030D10Rik, D17H6S81E-1, Bat1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B, Bat-1, Bat1a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53817
Homologene: 48376
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: GC-GAP, Grit, PX-RICS, p200RhoGAP, 3426406O18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Rprd1b
Name: regulation of nuclear pre-mRNA domain containing 1B
Synonyms: 2810446G03Rik, Crept, 2610304G08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70470
Homologene: 41426
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: PRO2405, 9530003A05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227634
Homologene: 19202
Atcay
Name: ataxia, cerebellar, Cayman type
Synonyms: BNIP-H, ji, 3322401A10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16467
HGNC: HGNC:779
Homologene: 13206
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22290
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Cndp1
Name: carnosine dipeptidase 1
Synonyms: Cn1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 338403
Homologene: 57178
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: glucocorticoid receptor-interacting protein 1, TIF2/GRIP-1, Grip1, TIF-2, TIF2, KAT13C, D1Ertd433e, SRC-2, bHLHe75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Tax1bp1
Name: Tax1 (human T cell leukemia virus type I) binding protein 1
Synonyms: 1200003J11Rik, D6Ertd772e, T6BP, TXBP151, D6Ertd404e, 1700069J21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52440
Homologene: 4395
Zfp746
Name: zinc finger protein 746
Synonyms: 2810407L07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69228
Homologene: 19783
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: lamellipodin, Lpd, C730009O10Rik, 9430025M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77300
Homologene: 71030
Nup160
Name: nucleoporin 160
Synonyms: Gtl1-13, 2810011M03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59015
Homologene: 32509
Sh3bp5l
Name: SH3 binding domain protein 5 like
Synonyms: 2310074E09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 79566
Homologene: 32584
Pot1a
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, Pot1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101185
Homologene: 32263
Fbxw11
Name: F-box and WD-40 domain protein 11
Synonyms: HOS, 2310065A07Rik, Fbxw1b, BTRC2, BTRCP2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103583
Homologene: 76444
Zdhhc11
Name: zinc finger, DHHC domain containing 11
Synonyms: 4933421L13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71164
VEGA: 13
Homologene: 128723
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: B430006D22Rik, D230004J03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 674895
Homologene: 130947
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Zfp605
Name: zinc finger protein 605
Synonyms: A830023I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 675812
Homologene: 52335
Npy4r
Name: neuropeptide Y receptor Y4
Synonyms: NYYR-D, Y4, Ppyr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19065
VEGA: 14
Homologene: 38119
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Pdzd8
Name: PDZ domain containing 8
Synonyms: Pdzk8, A630041P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: DIk, ANKK2, PKK, RIP4, Ankrd3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: C630029D13Rik, DGK-beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: Prkwnk4, 2010002J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Adamts19
Name: ADAM metallopeptidase with thrombospondin type 1 motif 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Arg2
Name: arginase type II
Synonyms: AII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11847
HGNC: HGNC:664
Homologene: 906
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: Hisppd2a, B430315C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29816
Homologene: 78348
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230815
Homologene: 69303
Or8j3c
Name: olfactory receptor family 8 subfamily J member 3C
Synonyms: GA_x6K02T2Q125-47892992-47892045, MOR185-1, Olfr1062
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259082
Homologene: 83135
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: Mitsugumin 56, Mg56, 1110011D13Rik, Gup1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Dll4
Name: delta like canonical Notch ligand 4
Synonyms: Delta4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54485
HGNC: HGNC:2910
Homologene: 10411
Krtap15-1
Name: keratin associated protein 15-1
Synonyms: Krtap15, Pmg-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26560
Homologene: 8439
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68810
Homologene: 44892
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3alpha, 4831426I19Rik, nesprin-3beta, nesprin-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Bend4
Name: BEN domain containing 4
Synonyms: D330027G24Rik, EG666938
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666938
Homologene: 52626
Cyp2t4
Name: cytochrome P450, family 2, subfamily t, polypeptide 4
Synonyms: LOC384724
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384724
Homologene: 76639
Or14c44
Name: olfactory receptor family 14 subfamily C member 44
Synonyms: Olfr301, MOR221-1P, MOR221-4, MOR221-1P, GA_x6K02T2NHDJ-9695951-9695766, Olfr302, Olfr1531-ps1, MOR211-8P, GA_x6K02T2NHDJ-9693313-9692378
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257958
Homologene: 128067
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: Akr1c1, 3alpha-HSD, estradiol 17-beta-dehydrogenase (A-specific), Hsd17b5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Cnn1
Name: calponin 1
Synonyms: CnnI, CN, calponin h1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12797
VEGA: 9
HGNC: HGNC:2155
Homologene: 995
Rtkn
Name: rhotekin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20166
Homologene: 7522
Tapbpl
Name: TAP binding protein-like
Synonyms: TAPBPL-R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213233
Homologene: 9958
Rgs19
Name: regulator of G-protein signaling 19
Synonyms: 2610042F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56470
Homologene: 23320
Or52a33
Name: olfactory receptor family 52 subfamily A member 33
Synonyms: MOR26-1, GA_x6K02T2PBJ9-6362863-6361910, Olfr622
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259087
Homologene: 100540
Cyp2ab1
Name: cytochrome P450, family 2, subfamily ab, polypeptide 1
Synonyms: EG224044
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224044
Homologene: 120487
4930480E11Rik
Name: RIKEN cDNA 4930480E11 gene
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 74910
Homologene: 136363
Cdpf1
Name: cysteine rich, DPF motif domain containing 1
Synonyms: 2210021J22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72355
Homologene: 45673
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,198,975 bp
  • C to T, chromosome 1 at 13,148,375 bp
  • A to G, chromosome 1 at 60,489,868 bp
  • T to C, chromosome 2 at 25,938,886 bp
  • G to C, chromosome 2 at 26,395,034 bp
  • G to A, chromosome 2 at 82,979,081 bp
  • G to A, chromosome 2 at 86,423,596 bp
  • A to G, chromosome 2 at 90,700,174 bp
  • A to T, chromosome 2 at 91,162,176 bp
  • T to A, chromosome 2 at 104,221,166 bp
  • T to C, chromosome 2 at 119,332,292 bp
  • T to A, chromosome 2 at 121,347,571 bp
  • T to A, chromosome 2 at 158,028,979 bp
  • C to T, chromosome 2 at 181,689,748 bp
  • T to A, chromosome 3 at 59,319,454 bp
  • T to C, chromosome 3 at 94,776,199 bp
  • T to C, chromosome 3 at 152,247,195 bp
  • C to T, chromosome 4 at 134,580,836 bp
  • T to C, chromosome 4 at 156,174,606 bp
  • T to A, chromosome 5 at 16,593,944 bp
  • C to G, chromosome 5 at 67,427,533 bp
  • T to A, chromosome 5 at 72,974,548 bp
  • T to A, chromosome 5 at 110,127,960 bp
  • T to C, chromosome 5 at 123,994,750 bp
  • T to C, chromosome 6 at 25,752,498 bp
  • A to G, chromosome 6 at 39,677,570 bp
  • A to G, chromosome 6 at 48,064,877 bp
  • A to G, chromosome 6 at 52,721,356 bp
  • A to G, chromosome 6 at 83,135,962 bp
  • A to G, chromosome 6 at 83,404,056 bp
  • A to G, chromosome 6 at 88,823,375 bp
  • A to T, chromosome 6 at 125,226,595 bp
  • G to A, chromosome 7 at 27,157,719 bp
  • T to C, chromosome 7 at 86,413,001 bp
  • C to T, chromosome 7 at 103,639,702 bp
  • A to G, chromosome 7 at 141,692,722 bp
  • T to A, chromosome 9 at 22,108,217 bp
  • T to C, chromosome 9 at 32,208,185 bp
  • T to A, chromosome 9 at 42,387,752 bp
  • A to T, chromosome 9 at 121,785,050 bp
  • A to T, chromosome 10 at 81,210,532 bp
  • T to C, chromosome 10 at 127,572,554 bp
  • A to G, chromosome 11 at 32,731,370 bp
  • A to T, chromosome 11 at 58,341,302 bp
  • C to A, chromosome 11 at 101,265,153 bp
  • T to C, chromosome 12 at 8,007,037 bp
  • T to C, chromosome 12 at 17,402,107 bp
  • T to C, chromosome 12 at 37,981,986 bp
  • G to A, chromosome 12 at 79,150,798 bp
  • TC to T, chromosome 12 at 104,961,571 bp
  • T to A, chromosome 13 at 4,447,020 bp
  • A to G, chromosome 13 at 38,193,548 bp
  • G to T, chromosome 13 at 73,992,097 bp
  • A to G, chromosome 14 at 14,853,965 bp
  • T to C, chromosome 14 at 34,146,915 bp
  • A to T, chromosome 14 at 121,308,022 bp
  • C to T, chromosome 15 at 85,809,293 bp
  • A to G, chromosome 16 at 20,315,896 bp
  • A to G, chromosome 16 at 88,829,094 bp
  • A to G, chromosome 16 at 97,743,249 bp
  • A to G, chromosome 17 at 35,253,488 bp
  • G to A, chromosome 18 at 10,515,319 bp
  • A to T, chromosome 18 at 58,837,902 bp
  • A to C, chromosome 18 at 67,675,792 bp
  • T to A, chromosome 18 at 84,622,197 bp
  • A to T, chromosome 19 at 59,300,645 bp
  • G to T, chromosome X at 78,370,705 bp
  • A to G, chromosome Y at 1,154,262 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7251 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045313-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.