Strain Name:
C57BL/6J-MtgxR7195Btlr/Mmmh
Stock Number:
045336-MU
Citation ID:
RRID:MMRRC_045336-MU
Other Names:
R7195 (G1)
Major Collection:

Strain Information

Sp4
Name: trans-acting transcription factor 4
Synonyms: HF-1b, HF1-b, 5730497N03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20688
VEGA: 12
Homologene: 2341
Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: D11Ertd530e, 2610028O16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Cds2
Name: CDP-diacylglycerol synthase 2
Synonyms: 5730450N06Rik, D2Wsu127e, 5730460C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Cd36
Name: CD36 molecule
Synonyms: Scarb3, FAT, fatty acid translocase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Mga
Name: MAX gene associated
Synonyms: Mad5, D030062C11Rik, Mga, C130042M01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227699
Homologene: 45683
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: AIP5, SDRP1, 8030445B08Rik, Tiul1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E1BAP5, Hnrnpul, Hnrpul1, E130317O14Rik, E1B-AP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232989
Homologene: 31419
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Ccm2
Name: cerebral cavernous malformation 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216527
Homologene: 12868
Zc3hc1
Name: zinc finger, C3HC type 1
Synonyms: Nipa, 1110054L24Rik, HSPC216
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232679
Homologene: 32315
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, 4833432B22Rik, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: CAMDI, 2610301F02Rik, ENSMUSG00000075261
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: Narg2, B230343B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93697
Homologene: 11618
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209018
Homologene: 44592
Ubxn11
Name: UBX domain protein 11
Synonyms: Soci, 4930506L07Rik, Ubxd5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67586
Homologene: 12159
Egfr
Name: epidermal growth factor receptor
Synonyms: 9030024J15Rik, Wa5, Erbb, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Akap7
Name: A kinase anchor protein 7
Synonyms: AKAP15, Akap18
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432442
HGNC: HGNC:377
Homologene: 49463
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242747
Homologene: 138474
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Cep19
Name: centrosomal protein 19
Synonyms: 1500031L02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66994
Homologene: 12065
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142682
Homologene: 9037
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, Flt-1, VEGFR1, VEGFR-1, sFlt1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Tbx3
Name: T-box 3
Synonyms: D5Ertd189e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21386
Homologene: 4371
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110893
Homologene: 62645
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Gm7168
Name: predicted gene 7168
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 635895
Homologene: 133217
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Wdr91
Name: WD repeat domain 91
Synonyms: 9530020G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101240
Homologene: 8562
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: testase 9, 1700056P18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Gdap1l1
Name: ganglioside-induced differentiation-associated protein 1-like 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228858
HGNC: HGNC:4213
Homologene: 11426
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545934
Homologene: 79577
Or51a39
Name: olfactory receptor family 51 subfamily A member 39
Synonyms: Olfr33, MOR11-2, GA_x6K02T2PBJ9-5431102-5430146, MTPCR33
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18332
Homologene: 81534
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Qrfp
Name: pyroglutamylated RFamide peptide
Synonyms: QRFP, P518
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227717
Homologene: 52341
Npas1
Name: neuronal PAS domain protein 1
Synonyms: bHLHe11, MOP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18142
HGNC: HGNC:7894
Homologene: 1886
Spock1
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
Synonyms: Ticn1, testican 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20745
Homologene: 80193
Or7h8
Name: olfactory receptor family 7 subfamily H member 8
Synonyms: MOR141-2, Olfr871, GA_x6K02T2PVTD-13952555-13953490
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258905
Homologene: 138319
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Sprr1a
Name: small proline-rich protein 1A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20753
Homologene: 105698
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Cd7
Name: CD7 antigen
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12516
HGNC: HGNC:1695
Homologene: 4471
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik, Fats
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71007
Homologene: 18998
Fam243
Name: family with sequence similarity 243
Synonyms: 4930563D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75328
VEGA: 16
Homologene: 57100
Ptpn9
Name: protein tyrosine phosphatase, non-receptor type 9
Synonyms: Meg2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56294
VEGA: 9
HGNC: HGNC:9661
Homologene: 2121
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22784
Homologene: 74470
Trabd2b
Name: TraB domain containing 2B
Synonyms: Hkat, Gm12824
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666048
Homologene: 85034
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Or55b4
Name: olfactory receptor family 55 subfamily B member 4
Synonyms: Olfr544, GA_x6K02T2PBJ9-5206624-5205620, MOR42-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257926
Homologene: 133590
Oxct1
Name: 3-oxoacid CoA transferase 1
Synonyms: 2610008O03Rik, Scot-s
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67041
HGNC: HGNC:8527
Homologene: 377
Or3a4
Name: olfactory receptor family 3 subfamily A member 4
Synonyms: GA_x6K02T2P1NL-4211516-4210581, MOR255-1, Olfr399
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259006
Homologene: 27325
Fam78b
Name: family with sequence similarity 78, member B
Synonyms: C030020L09Rik, C030014K22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226610
Homologene: 18451
Or4c110
Name: olfactory receptor family 4 subfamily C member 110
Synonyms: GA_x6K02T2Q125-50482823-50481885, MOR233-13, Olfr1215
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258451
Homologene: 74071
Pex11g
Name: peroxisomal biogenesis factor 11 gamma
Synonyms: 1810022F11Rik, Pex11c, Pex11gamma, 1810049N02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69129
Homologene: 12298
Or1p1b
Name: olfactory receptor family 1 subfamily P member 1B
Synonyms: MOR133-5P, Olfr404-ps1, GA_x6K02T2P1NL-4385196-4386167
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257920
Iglv2
Name: immunoglobulin lambda variable 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110612
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,019,669 bp
  • A to G, chromosome 1 at 82,287,456 bp
  • A to G, chromosome 1 at 167,078,562 bp
  • A to G, chromosome 2 at 25,442,076 bp
  • G to A, chromosome 2 at 30,341,830 bp
  • C to T, chromosome 2 at 31,808,692 bp
  • T to G, chromosome 2 at 77,049,583 bp
  • G to A, chromosome 2 at 89,001,731 bp
  • T to A, chromosome 2 at 119,917,328 bp
  • T to A, chromosome 2 at 132,293,284 bp
  • A to T, chromosome 2 at 163,446,130 bp
  • A to G, chromosome 2 at 181,007,231 bp
  • T to C, chromosome 3 at 64,116,479 bp
  • G to T, chromosome 3 at 92,484,367 bp
  • A to G, chromosome 4 at 19,627,908 bp
  • G to T, chromosome 4 at 32,701,823 bp
  • T to C, chromosome 4 at 114,409,440 bp
  • A to C, chromosome 4 at 134,126,415 bp
  • C to A, chromosome 4 at 140,611,410 bp
  • G to A, chromosome 4 at 147,826,179 bp
  • A to G, chromosome 5 at 17,814,189 bp
  • A to G, chromosome 5 at 31,088,795 bp
  • A to G, chromosome 5 at 119,675,583 bp
  • C to T, chromosome 5 at 147,603,576 bp
  • C to T, chromosome 6 at 4,510,753 bp
  • T to C, chromosome 6 at 30,382,548 bp
  • T to C, chromosome 6 at 34,889,274 bp
  • T to C, chromosome 7 at 16,474,808 bp
  • T to A, chromosome 7 at 23,702,459 bp
  • T to C, chromosome 7 at 25,724,778 bp
  • A to G, chromosome 7 at 84,943,139 bp
  • A to T, chromosome 7 at 102,484,367 bp
  • A to G, chromosome 7 at 102,713,666 bp
  • A to G, chromosome 7 at 134,295,122 bp
  • A to G, chromosome 8 at 3,459,237 bp
  • A to T, chromosome 8 at 40,824,775 bp
  • T to C, chromosome 8 at 121,608,461 bp
  • A to G, chromosome 9 at 20,212,544 bp
  • T to A, chromosome 9 at 57,022,249 bp
  • G to A, chromosome 9 at 67,945,825 bp
  • C to T, chromosome 9 at 69,428,500 bp
  • A to T, chromosome 9 at 107,928,870 bp
  • A to T, chromosome 10 at 25,271,507 bp
  • T to C, chromosome 11 at 6,596,302 bp
  • C to T, chromosome 11 at 16,868,162 bp
  • T to C, chromosome 11 at 58,288,416 bp
  • T to A, chromosome 11 at 74,054,397 bp
  • G to T, chromosome 11 at 74,239,568 bp
  • T to A, chromosome 11 at 80,013,483 bp
  • G to A, chromosome 11 at 103,457,775 bp
  • T to C, chromosome 11 at 121,038,249 bp
  • T to C, chromosome 12 at 81,314,273 bp
  • G to T, chromosome 12 at 118,300,072 bp
  • C to T, chromosome 13 at 57,907,502 bp
  • A to T, chromosome 13 at 113,367,929 bp
  • T to C, chromosome 14 at 30,899,475 bp
  • A to T, chromosome 14 at 96,280,077 bp
  • T to C, chromosome 15 at 4,128,901 bp
  • C to T, chromosome 15 at 34,510,379 bp
  • A to G, chromosome 16 at 19,260,510 bp
  • T to C, chromosome 16 at 21,456,282 bp
  • A to G, chromosome 16 at 32,107,086 bp
  • C to T, chromosome 16 at 92,321,149 bp
  • T to A, chromosome 17 at 13,949,360 bp
  • G to T, chromosome 18 at 37,519,288 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7195 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045336-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.