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Strain Name:
C57BL/6J-MtgxR7209Btlr/Mmmh
Stock Number:
045338-MU
Citation ID:
RRID:MMRRC_045338-MU
Other Names:
R7209 (G1)
Major Collection:

Strain Information

Lypd2
Name: Ly6/Plaur domain containing 2
Synonyms: 0610005K03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68311
Homologene: 19022
Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Madcam1
Name: mucosal vascular addressin cell adhesion molecule 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17123
VEGA: 10
HGNC: HGNC:6765
Homologene: 8413
Rrp12
Name: ribosomal RNA processing 12 homolog
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107094
VEGA: 19
Homologene: 22370
Dhx9
Name: DExH-box helicase 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: 1110001E24Rik, Txndc4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 60,237,151 bp
  • T to C, chromosome 1 at 73,953,915 bp
  • T to A, chromosome 1 at 88,503,282 bp
  • A to G, chromosome 1 at 93,775,233 bp
  • C to A, chromosome 1 at 105,750,357 bp
  • T to C, chromosome 1 at 153,464,623 bp
  • A to G, chromosome 1 at 195,168,724 bp
  • T to C, chromosome 2 at 10,091,753 bp
  • T to C, chromosome 2 at 24,397,345 bp
  • T to A, chromosome 2 at 70,016,134 bp
  • T to C, chromosome 2 at 101,566,382 bp
  • T to A, chromosome 2 at 101,895,138 bp
  • C to A, chromosome 2 at 120,862,765 bp
  • G to A, chromosome 3 at 90,613,788 bp
  • A to T, chromosome 3 at 94,198,705 bp
  • A to G, chromosome 3 at 100,647,079 bp
  • G to A, chromosome 3 at 138,443,148 bp
  • A to T, chromosome 4 at 48,211,704 bp
  • A to T, chromosome 4 at 49,503,065 bp
  • T to G, chromosome 4 at 62,486,615 bp
  • C to T, chromosome 4 at 81,306,877 bp
  • G to A, chromosome 4 at 94,925,569 bp
  • A to C, chromosome 4 at 150,635,212 bp
  • C to A, chromosome 4 at 154,839,128 bp
  • C to A, chromosome 5 at 70,754,170 bp
  • T to A, chromosome 5 at 77,343,179 bp
  • A to G, chromosome 5 at 129,998,546 bp
  • C to T, chromosome 5 at 137,870,864 bp
  • A to G, chromosome 5 at 150,053,098 bp
  • T to C, chromosome 6 at 34,356,272 bp
  • T to C, chromosome 7 at 10,710,370 bp
  • T to A, chromosome 7 at 105,566,085 bp
  • T to C, chromosome 8 at 77,564,998 bp
  • C to A, chromosome 8 at 110,489,792 bp
  • A to T, chromosome 9 at 27,009,992 bp
  • A to G, chromosome 9 at 66,385,032 bp
  • A to T, chromosome 10 at 23,940,699 bp
  • A to T, chromosome 10 at 79,665,058 bp
  • T to A, chromosome 10 at 81,386,040 bp
  • G to A, chromosome 11 at 29,529,996 bp
  • A to T, chromosome 11 at 33,134,315 bp
  • C to A, chromosome 11 at 59,085,107 bp
  • C to A, chromosome 11 at 74,854,325 bp
  • C to T, chromosome 11 at 97,476,085 bp
  • G to C, chromosome 11 at 97,492,447 bp
  • T to A, chromosome 12 at 57,543,291 bp
  • T to A, chromosome 12 at 59,154,390 bp
  • C to A, chromosome 12 at 79,050,376 bp
  • T to A, chromosome 12 at 84,396,928 bp
  • T to C, chromosome 12 at 103,125,624 bp
  • A to G, chromosome 13 at 19,261,164 bp
  • G to A, chromosome 13 at 104,072,898 bp
  • T to C, chromosome 13 at 108,382,855 bp
  • A to G, chromosome 14 at 51,655,906 bp
  • A to G, chromosome 14 at 52,410,093 bp
  • A to G, chromosome 14 at 68,529,819 bp
  • A to G, chromosome 14 at 70,267,498 bp
  • T to C, chromosome 15 at 28,459,225 bp
  • T to G, chromosome 15 at 74,569,948 bp
  • C to T, chromosome 15 at 74,732,417 bp
  • T to A, chromosome 16 at 93,769,845 bp
  • T to C, chromosome 16 at 96,650,344 bp
  • A to T, chromosome 17 at 19,531,314 bp
  • A to T, chromosome 17 at 33,003,470 bp
  • C to A, chromosome 17 at 86,001,520 bp
  • A to T, chromosome 18 at 12,104,172 bp
  • A to G, chromosome 18 at 36,773,540 bp
  • A to G, chromosome 19 at 5,654,975 bp
  • A to G, chromosome 19 at 39,689,205 bp
  • A to C, chromosome 19 at 41,872,949 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7209 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045338-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.