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Strain Name:
C57BL/6J-MtgxR7242Btlr/Mmmh
Stock Number:
045349-MU
Citation ID:
RRID:MMRRC_045349-MU
Other Names:
R7242 (G1)
Major Collection:

Strain Information

Chrm4
Name: cholinergic receptor, muscarinic 4
Synonyms: Chrm-4, muscarinic acetylcholine receptor 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12672
HGNC: HGNC:1953
Homologene: 20192
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, RA-GEF-1, CNRasGEF, nRapGEP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Dmtn
Name: dematin actin binding protein
Synonyms: dematin, Epb4.9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13829
VEGA: 14
HGNC: HGNC:3382
Homologene: 1496
Fzd8
Name: frizzled class receptor 8
Synonyms: Fz8, mFZ8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14370
VEGA: 18
HGNC: HGNC:4046
Homologene: 40606
Mib1
Name: MIB E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, Mib, skeletrophin, mind bomb-1, mindbomb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225164
Homologene: 10810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,709,474 bp
  • A to G, chromosome 1 at 65,388,620 bp
  • C to T, chromosome 1 at 87,197,479 bp
  • A to G, chromosome 1 at 159,284,548 bp
  • G to A, chromosome 2 at 10,091,793 bp
  • C to T, chromosome 2 at 18,293,972 bp
  • T to C, chromosome 2 at 76,721,729 bp
  • G to A, chromosome 2 at 87,358,082 bp
  • T to A, chromosome 2 at 90,745,796 bp
  • T to A, chromosome 2 at 91,003,257 bp
  • T to A, chromosome 2 at 91,927,250 bp
  • T to C, chromosome 2 at 163,828,852 bp
  • T to G, chromosome 3 at 32,865,743 bp
  • C to T, chromosome 3 at 61,363,835 bp
  • G to A, chromosome 3 at 79,087,903 bp
  • T to A, chromosome 3 at 88,450,109 bp
  • T to C, chromosome 3 at 98,853,210 bp
  • A to G, chromosome 3 at 103,998,696 bp
  • A to G, chromosome 4 at 43,542,602 bp
  • T to A, chromosome 4 at 44,360,885 bp
  • T to G, chromosome 4 at 88,309,906 bp
  • A to T, chromosome 4 at 98,591,933 bp
  • A to T, chromosome 4 at 106,762,493 bp
  • C to T, chromosome 4 at 118,593,096 bp
  • T to A, chromosome 5 at 9,149,016 bp
  • T to C, chromosome 5 at 72,305,055 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • A to G, chromosome 5 at 138,163,580 bp
  • A to T, chromosome 5 at 146,184,867 bp
  • G to A, chromosome 6 at 17,491,317 bp
  • T to A, chromosome 6 at 41,313,454 bp
  • T to A, chromosome 6 at 48,473,952 bp
  • A to T, chromosome 6 at 48,931,128 bp
  • A to G, chromosome 6 at 83,711,316 bp
  • A to T, chromosome 7 at 8,485,613 bp
  • G to A, chromosome 7 at 29,173,034 bp
  • A to G, chromosome 7 at 45,439,668 bp
  • A to G, chromosome 7 at 49,772,606 bp
  • T to A, chromosome 7 at 92,572,568 bp
  • T to G, chromosome 7 at 108,565,712 bp
  • A to T, chromosome 7 at 139,847,657 bp
  • T to A, chromosome 8 at 21,940,757 bp
  • A to C, chromosome 8 at 25,088,395 bp
  • A to G, chromosome 8 at 27,122,027 bp
  • T to C, chromosome 8 at 87,904,527 bp
  • A to G, chromosome 9 at 38,995,141 bp
  • A to G, chromosome 9 at 67,028,101 bp
  • A to G, chromosome 9 at 77,785,371 bp
  • T to C, chromosome 10 at 4,453,475 bp
  • A to T, chromosome 10 at 78,984,497 bp
  • A to G, chromosome 10 at 79,856,388 bp
  • T to A, chromosome 11 at 23,020,037 bp
  • T to A, chromosome 11 at 45,984,520 bp
  • A to T, chromosome 11 at 110,241,653 bp
  • G to T, chromosome 12 at 51,593,561 bp
  • C to T, chromosome 12 at 87,468,645 bp
  • G to A, chromosome 13 at 94,233,140 bp
  • A to G, chromosome 13 at 102,738,478 bp
  • A to G, chromosome 14 at 30,178,706 bp
  • T to C, chromosome 14 at 70,618,020 bp
  • T to A, chromosome 15 at 31,273,308 bp
  • T to C, chromosome 15 at 38,501,505 bp
  • T to C, chromosome 16 at 35,156,835 bp
  • A to T, chromosome 16 at 35,933,401 bp
  • T to C, chromosome 17 at 28,363,405 bp
  • A to G, chromosome 17 at 33,067,127 bp
  • G to A, chromosome 17 at 89,910,135 bp
  • A to T, chromosome 18 at 9,214,171 bp
  • T to A, chromosome 18 at 10,741,011 bp
  • T to C, chromosome 18 at 11,840,007 bp
  • A to T, chromosome 18 at 36,748,222 bp
  • A to T, chromosome 18 at 37,144,893 bp
  • C to T, chromosome 18 at 38,203,217 bp
  • T to A, chromosome 19 at 8,755,277 bp
  • G to T, chromosome 19 at 39,617,339 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045349-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.