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Strain Name:
C57BL/6J-MtgxR7307Btlr/Mmmh
Stock Number:
045366-MU
Citation ID:
RRID:MMRRC_045366-MU
Other Names:
R7307 (G1)
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54524
Homologene: 10301
Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, ZAKI-4, Csp2, Dscr1l1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Enc1
Name: ectodermal-neural cortex 1
Synonyms: PIG10, Nrpb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13803
VEGA: 13
HGNC: HGNC:3345
Homologene: 2694
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27388
Homologene: 8462
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 2 at 13,340,332 bp
  • T to C, chromosome 2 at 31,343,081 bp
  • G to A, chromosome 2 at 36,850,125 bp
  • A to T, chromosome 2 at 111,478,760 bp
  • T to A, chromosome 2 at 127,434,890 bp
  • C to T, chromosome 2 at 142,712,931 bp
  • T to C, chromosome 2 at 157,135,020 bp
  • T to C, chromosome 3 at 16,183,500 bp
  • G to T, chromosome 3 at 98,619,769 bp
  • C to T, chromosome 3 at 100,202,033 bp
  • T to A, chromosome 3 at 103,587,472 bp
  • T to C, chromosome 3 at 104,889,353 bp
  • T to A, chromosome 3 at 135,318,390 bp
  • T to A, chromosome 3 at 146,015,798 bp
  • A to T, chromosome 4 at 32,816,949 bp
  • A to T, chromosome 4 at 138,262,643 bp
  • A to C, chromosome 4 at 143,896,775 bp
  • T to C, chromosome 5 at 113,273,646 bp
  • A to G, chromosome 5 at 120,186,218 bp
  • C to A, chromosome 6 at 3,372,600 bp
  • T to A, chromosome 6 at 88,814,121 bp
  • T to C, chromosome 6 at 120,215,431 bp
  • G to T, chromosome 7 at 16,368,544 bp
  • A to G, chromosome 7 at 23,321,528 bp
  • A to G, chromosome 7 at 28,042,660 bp
  • T to C, chromosome 7 at 30,580,471 bp
  • A to G, chromosome 7 at 102,134,795 bp
  • G to T, chromosome 7 at 103,716,966 bp
  • T to C, chromosome 7 at 126,866,818 bp
  • G to A, chromosome 7 at 140,705,147 bp
  • A to G, chromosome 7 at 141,151,732 bp
  • G to A, chromosome 7 at 141,842,294 bp
  • A to T, chromosome 9 at 21,485,687 bp
  • T to A, chromosome 9 at 21,638,800 bp
  • A to G, chromosome 9 at 42,377,992 bp
  • T to C, chromosome 9 at 44,694,047 bp
  • T to G, chromosome 9 at 70,610,959 bp
  • T to A, chromosome 10 at 28,589,008 bp
  • T to A, chromosome 10 at 34,591,938 bp
  • G to A, chromosome 10 at 76,257,092 bp
  • A to G, chromosome 10 at 80,029,182 bp
  • A to G, chromosome 11 at 28,399,384 bp
  • A to T, chromosome 11 at 69,747,292 bp
  • G to T, chromosome 11 at 72,070,964 bp
  • C to T, chromosome 11 at 97,338,846 bp
  • T to A, chromosome 11 at 98,249,800 bp
  • T to C, chromosome 11 at 98,764,308 bp
  • A to C, chromosome 11 at 115,348,482 bp
  • A to T, chromosome 12 at 13,223,959 bp
  • T to A, chromosome 12 at 84,418,179 bp
  • A to C, chromosome 12 at 88,181,749 bp
  • G to A, chromosome 13 at 18,239,713 bp
  • A to T, chromosome 13 at 58,563,172 bp
  • A to C, chromosome 13 at 97,245,093 bp
  • T to G, chromosome 13 at 99,988,600 bp
  • A to G, chromosome 14 at 24,459,987 bp
  • A to G, chromosome 14 at 37,072,199 bp
  • T to A, chromosome 14 at 75,330,541 bp
  • G to T, chromosome 15 at 11,217,813 bp
  • T to C, chromosome 15 at 35,841,545 bp
  • T to C, chromosome 15 at 98,670,799 bp
  • A to T, chromosome 15 at 98,849,418 bp
  • A to G, chromosome 15 at 101,542,907 bp
  • G to A, chromosome 16 at 17,118,395 bp
  • T to G, chromosome 16 at 21,222,226 bp
  • A to T, chromosome 17 at 24,974,745 bp
  • T to A, chromosome 17 at 44,021,102 bp
  • C to T, chromosome 17 at 57,007,833 bp
  • G to C, chromosome 17 at 80,347,120 bp
  • T to C, chromosome 18 at 10,538,142 bp
  • A to T, chromosome 18 at 37,335,478 bp
  • T to A, chromosome 18 at 65,451,569 bp
  • C to G, chromosome 19 at 5,993,908 bp
  • A to G, chromosome 19 at 55,313,250 bp
  • A to T, chromosome 19 at 57,472,703 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7307 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045366-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.