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Strain Name:
C57BL/6J-MtgxR7252Btlr/Mmmh
Stock Number:
045385-MU
Citation ID:
RRID:MMRRC_045385-MU
Other Names:
R7252 (G1)
Major Collection:

Strain Information

Baiap2
Name: brain-specific angiogenesis inhibitor 1-associated protein 2
Synonyms: IRSp53
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108100
HGNC: HGNC:947
Homologene: 9697
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: LARG, 2310014B11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 5730409A01Rik, 1810061H24Rik, SAP130, RSE1, D8Ertd633e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101943
Homologene: 6579
Rcc2
Name: regulator of chromosome condensation 2
Synonyms: 2610529N02Rik, 2610510H01Rik, Td60
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108911
Homologene: 10282
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 36,550,015 bp
  • G to A, chromosome 1 at 133,094,734 bp
  • A to G, chromosome 1 at 175,775,674 bp
  • G to C, chromosome 2 at 26,395,034 bp
  • A to C, chromosome 2 at 30,101,892 bp
  • A to G, chromosome 2 at 31,642,374 bp
  • A to T, chromosome 2 at 33,168,188 bp
  • A to G, chromosome 2 at 52,324,961 bp
  • T to A, chromosome 2 at 89,326,285 bp
  • C to G, chromosome 2 at 117,263,892 bp
  • A to G, chromosome 2 at 130,144,964 bp
  • T to A, chromosome 2 at 132,381,440 bp
  • T to C, chromosome 2 at 146,342,751 bp
  • A to T, chromosome 2 at 175,133,198 bp
  • T to A, chromosome 3 at 83,325,303 bp
  • C to T, chromosome 3 at 89,316,664 bp
  • T to A, chromosome 3 at 142,720,458 bp
  • A to G, chromosome 4 at 88,426,763 bp
  • T to C, chromosome 4 at 134,148,031 bp
  • T to C, chromosome 4 at 138,720,876 bp
  • G to A, chromosome 4 at 140,702,275 bp
  • T to C, chromosome 4 at 144,212,940 bp
  • T to C, chromosome 4 at 150,098,874 bp
  • T to A, chromosome 4 at 155,962,615 bp
  • C to T, chromosome 5 at 20,908,198 bp
  • C to T, chromosome 5 at 27,760,086 bp
  • A to G, chromosome 5 at 92,650,788 bp
  • T to C, chromosome 5 at 151,063,169 bp
  • A to T, chromosome 6 at 35,069,427 bp
  • A to G, chromosome 6 at 40,544,769 bp
  • A to T, chromosome 6 at 113,556,285 bp
  • T to A, chromosome 6 at 123,741,581 bp
  • T to C, chromosome 6 at 123,787,232 bp
  • G to T, chromosome 7 at 5,034,417 bp
  • C to A, chromosome 7 at 19,612,613 bp
  • C to T, chromosome 7 at 44,327,161 bp
  • T to C, chromosome 7 at 78,780,588 bp
  • A to G, chromosome 8 at 21,905,457 bp
  • T to A, chromosome 8 at 56,298,426 bp
  • T to A, chromosome 8 at 58,911,804 bp
  • A to G, chromosome 8 at 71,394,602 bp
  • A to G, chromosome 8 at 84,861,328 bp
  • A to G, chromosome 8 at 109,660,698 bp
  • A to C, chromosome 8 at 110,839,930 bp
  • G to A, chromosome 9 at 9,831,635 bp
  • A to G, chromosome 9 at 18,857,252 bp
  • C to T, chromosome 9 at 40,187,361 bp
  • A to T, chromosome 9 at 43,015,909 bp
  • G to A, chromosome 9 at 44,623,753 bp
  • C to T, chromosome 9 at 63,512,236 bp
  • T to A, chromosome 9 at 86,500,821 bp
  • C to T, chromosome 10 at 76,273,202 bp
  • A to G, chromosome 10 at 77,993,429 bp
  • T to C, chromosome 10 at 107,821,943 bp
  • T to C, chromosome 10 at 128,381,996 bp
  • C to T, chromosome 10 at 130,386,410 bp
  • T to A, chromosome 11 at 29,563,937 bp
  • A to T, chromosome 11 at 55,311,262 bp
  • A to G, chromosome 11 at 62,724,829 bp
  • T to A, chromosome 11 at 69,026,174 bp
  • A to G, chromosome 11 at 70,654,471 bp
  • A to C, chromosome 11 at 80,337,585 bp
  • G to A, chromosome 11 at 82,764,708 bp
  • A to G, chromosome 11 at 99,597,970 bp
  • G to T, chromosome 11 at 120,003,039 bp
  • A to T, chromosome 12 at 55,600,520 bp
  • A to G, chromosome 13 at 8,570,180 bp
  • T to C, chromosome 14 at 73,166,780 bp
  • A to T, chromosome 15 at 11,035,939 bp
  • G to T, chromosome 15 at 83,572,265 bp
  • A to G, chromosome 15 at 98,844,266 bp
  • A to T, chromosome 16 at 19,606,499 bp
  • G to A, chromosome 16 at 55,970,116 bp
  • A to G, chromosome 16 at 58,718,397 bp
  • T to C, chromosome 16 at 87,484,919 bp
  • A to T, chromosome 18 at 5,214,874 bp
  • G to T, chromosome 18 at 24,601,385 bp
  • A to G, chromosome 18 at 59,066,908 bp
  • T to C, chromosome 19 at 8,723,157 bp
  • T to C, chromosome 19 at 16,661,064 bp
  • G to T, chromosome 19 at 41,941,551 bp
  • T to A, chromosome 19 at 43,827,949 bp
  • G to T, chromosome X at 78,370,705 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7252 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045385-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.