Strain Name:
C57BL/6J-MtgxR7272Btlr/Mmmh
Stock Number:
045391-MU
Citation ID:
RRID:MMRRC_045391-MU
Other Names:
R7272 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Ncaph2
Name: non-SMC condensin II complex, subunit H2
Synonyms: Kleisin beta, D15Ertd785e, 0610010J20Rik, 2610524G04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52683
Homologene: 12045
Stx12
Name: syntaxin 12
Synonyms: Stx13, syntaxin 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100226
Homologene: 128192
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: N-ethylmaleimide sensitive factor, SKD2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Sspn
Name: sarcospan
Synonyms: Krag
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16651
Homologene: 3727
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, chromatin remodeling factor, E430018P19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: Narg2, B230343B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93697
Homologene: 11618
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71888
Homologene: 74433
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: C79645, 1110004L07Rik, EXPORTIN-T
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73192
VEGA: 10
Homologene: 38291
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: Sorla, LR11, mSorLA, 2900010L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Pom121
Name: nuclear pore membrane protein 121
Synonyms: 2610027A18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107939
Homologene: 70878
Spindoc
Name: spindlin interactor and repressor of chromatin binding
Synonyms: AI846148
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68229
VEGA: 19
Homologene: 19195
Slc44a3
Name: solute carrier family 44, member 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213603
Homologene: 64830
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Anxa9
Name: annexin A9
Synonyms: 2310069F17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71790
HGNC: HGNC:547
Homologene: 2643
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, spermNHE, Slc9a10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Kctd18
Name: potassium channel tetramerisation domain containing 18
Synonyms: 4932411A20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 51960
Homologene: 12710
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Cryga
Name: crystallin, gamma A
Synonyms: Cryg-4, DGcry-4, Secc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12964
HGNC: HGNC:2408
Homologene: 129704
Zfp385c
Name: zinc finger protein 385C
Synonyms: A930006D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 278304
Homologene: 65334
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Pbk
Name: PDZ binding kinase
Synonyms: 2810434B10Rik, D14Ertd732e, TOPK
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52033
Homologene: 32415
Mss51
Name: MSS51 mitochondrial translational activator
Synonyms: Zmynd17, 4833444M15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74843
VEGA: 14
Homologene: 27997
Cep89
Name: centrosomal protein 89
Synonyms: Ccdc123, 2610507L03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72140
Homologene: 12444
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21881
Homologene: 68154
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Ndufa4
Name: Ndufa4, mitochondrial complex associated
Synonyms: MLRQ
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17992
HGNC: HGNC:7687
Homologene: 37629
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320492
Homologene: 14194
Yrdc
Name: yrdC domain containing (E.coli)
Synonyms: IRIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230734
Homologene: 11635
Krtap13-21
Name: keratin associated protein 13-21
Synonyms: 2310057N15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69696
Homologene: 114409
Edn2
Name: endothelin 2
Synonyms: VIC, vasoactive intestinal contractor peptide
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13615
HGNC: HGNC:3177
Homologene: 1477
Marchf3
Name: membrane associated ring-CH-type finger 3
Synonyms: March3, A530081L18Rik, 6330411I15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 320253
Homologene: 35310
Gpr33
Name: G protein-coupled receptor 33
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14762
HGNC: HGNC:4489
Homologene: 7345
Trmt10a
Name: tRNA methyltransferase 10A
Synonyms: Rg9mtd2, 3110023L08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108943
Homologene: 6886
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nep2, Nl1, SEP, NEPLP gamma, NEPLP beta, NEPLP alpha, Mell1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27390
Homologene: 22778
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237886
Homologene: 45432
Sdc1
Name: syndecan 1
Synonyms: Synd, CD138, syn-1, Synd1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20969
Homologene: 2252
Vgll2
Name: vestigial like family member 2
Synonyms: Vgl-2, C130057C21Rik, VITO-1, Vito1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215031
Homologene: 35066
Ms4a7
Name: membrane-spanning 4-domains, subfamily A, member 7
Synonyms: CD20l4, CFFMA, A430103C15Rik, 9130422I10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109225
Homologene: 10922
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: nectin 4, Pvrl4, Prr4, 1200017F15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71740
Homologene: 32744
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: MOR135-24, Olfr391, Olfr391-ps, MOR135-30_i, Olfr391-ps1, GA_x6K02T2P1NL-3951666-3950698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
4930558K02Rik
Name: RIKEN cDNA 4930558K02 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75368
Homologene: 51403
Vmn1r114
Name: vomeronasal 1 receptor 114
Synonyms: Gm10669
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042996
Homologene: 104166
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 11,588,471 bp
  • T to C, chromosome 1 at 57,956,551 bp
  • A to T, chromosome 1 at 65,103,222 bp
  • T to C, chromosome 1 at 71,248,432 bp
  • T to C, chromosome 1 at 139,458,328 bp
  • A to G, chromosome 1 at 155,953,588 bp
  • T to A, chromosome 1 at 161,942,523 bp
  • A to G, chromosome 1 at 171,386,644 bp
  • A to G, chromosome 3 at 89,054,634 bp
  • A to G, chromosome 3 at 95,305,873 bp
  • T to C, chromosome 3 at 121,461,115 bp
  • A to T, chromosome 3 at 122,508,396 bp
  • C to T, chromosome 3 at 126,943,133 bp
  • A to T, chromosome 3 at 127,598,760 bp
  • T to A, chromosome 3 at 138,154,766 bp
  • G to A, chromosome 4 at 120,161,946 bp
  • G to A, chromosome 4 at 124,851,027 bp
  • A to T, chromosome 4 at 132,857,376 bp
  • A to T, chromosome 4 at 154,894,090 bp
  • G to A, chromosome 5 at 110,755,645 bp
  • G to A, chromosome 5 at 135,381,087 bp
  • G to A, chromosome 6 at 11,905,210 bp
  • T to A, chromosome 6 at 145,961,474 bp
  • A to G, chromosome 7 at 20,811,618 bp
  • A to T, chromosome 7 at 35,438,463 bp
  • C to A, chromosome 7 at 128,205,073 bp
  • T to C, chromosome 8 at 61,125,086 bp
  • C to T, chromosome 9 at 42,063,710 bp
  • T to A, chromosome 9 at 69,417,083 bp
  • C to A, chromosome 10 at 27,124,556 bp
  • C to A, chromosome 10 at 52,027,662 bp
  • C to T, chromosome 10 at 121,617,189 bp
  • T to C, chromosome 11 at 30,114,859 bp
  • T to A, chromosome 11 at 73,798,869 bp
  • T to C, chromosome 11 at 82,981,561 bp
  • C to T, chromosome 11 at 100,012,011 bp
  • C to T, chromosome 11 at 100,630,039 bp
  • T to A, chromosome 11 at 103,827,238 bp
  • T to A, chromosome 12 at 8,790,554 bp
  • T to C, chromosome 12 at 52,024,065 bp
  • T to C, chromosome 12 at 76,048,643 bp
  • T to C, chromosome 13 at 77,323,536 bp
  • G to A, chromosome 14 at 20,484,913 bp
  • G to T, chromosome 14 at 30,565,607 bp
  • G to T, chromosome 14 at 55,870,415 bp
  • T to A, chromosome 14 at 65,815,172 bp
  • A to G, chromosome 15 at 45,113,180 bp
  • T to C, chromosome 15 at 76,174,953 bp
  • T to A, chromosome 15 at 82,792,563 bp
  • A to G, chromosome 15 at 89,364,182 bp
  • A to G, chromosome 16 at 45,581,515 bp
  • A to T, chromosome 16 at 88,773,635 bp
  • T to G, chromosome 18 at 56,762,521 bp
  • C to T, chromosome 19 at 7,382,720 bp
  • T to A, chromosome 19 at 11,333,278 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7272 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045391-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.