Strain Name:
C57BL/6J-MtgxR7312Btlr/Mmmh
Stock Number:
045410-MU
Citation ID:
RRID:MMRRC_045410-MU
Other Names:
R7312 (G1)
Major Collection:

Strain Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, C430013M08Rik, 5730544L10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
S1pr2
Name: sphingosine-1-phosphate receptor 2
Synonyms: Edg5, Gpcr13, 1100001A16Rik, LPb2, H218, S1P2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14739
VEGA: 9
HGNC: HGNC:3169
Homologene: 3118
Lrrfip2
Name: leucine rich repeat (in FLII) interacting protein 2
Synonyms: 5133400F20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71268
HGNC: HGNC:6703
Homologene: 22476
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71521
Homologene: 22877
Nav2
Name: neuron navigator 2
Synonyms: 5330421F07Rik, RAINB2, POMFIL2, HELAD1, Unc53H2, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Erp29
Name: endoplasmic reticulum protein 29
Synonyms: Erp31, PDI-Db, 2810446M09Rik, Erp28, 1200015M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67397
Homologene: 4963
Lmo1
Name: LIM domain only 1
Synonyms: Ttg1, Rbtn-1, Rbtn1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109594
HGNC: HGNC:6641
Homologene: 48101
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Cd300lg
Name: CD300 molecule like family member G
Synonyms: D11Ertd736e, Clm9, 2310016B05Rik, nepmucin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52685
Homologene: 17059
Tln1
Name: talin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21894
Homologene: 21267
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Efl1
Name: elongation factor like GTPase 1
Synonyms: D7Ertd791e, Eftud1, 6030468D11Rik, 4932434J20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101592
Homologene: 11599
Nbeal1
Name: neurobeachin like 1
Synonyms: A530083I02Rik, A530050O19Rik, 2310076G13Rik, ALS2CR17
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Styxl2
Name: serine/threonine/tyrosine interacting like 2
Synonyms: Dusp27, C130085G02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240892
Homologene: 18949
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64297
Homologene: 9435
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, Cav1.2, Cchl1a1, L-type Cav1.2, D930026N18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: Ifnm, A930027I18Rik, IL-12RB2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
P2rx5
Name: purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms: P2X5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94045
HGNC: HGNC:8536
Homologene: 1924
Oog3
Name: oogenesin 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100012
Homologene: 129883
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: TFL, D730019B10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237256
VEGA: 10
Homologene: 18225
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Or5w20
Name: olfactory receptor family 5 subfamily W member 20
Synonyms: GA_x6K02T2Q125-49395950-49396882, Olfr1153, MOR177-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258633
Homologene: 27230
Dennd2d
Name: DENN domain containing 2D
Synonyms: 2010308M01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72121
Homologene: 11776
Zfp963
Name: zinc finger protein 963
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 620419
Homologene: 49795
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20678
Homologene: 21378
Or2g25
Name: olfactory receptor family 2 subfamily G member 25
Synonyms: GA_x6K02T2PSCP-2119438-2118485, Olfr117, MOR256-33
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258263
Homologene: 105876
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Ppm1l
Name: protein phosphatase 1 (formerly 2C)-like
Synonyms: PP2C-epsilon, Pp2ce, 5930404J21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242083
Homologene: 33158
Hoxc9
Name: homeobox C9
Synonyms: Hox-3.2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15427
HGNC: HGNC:5130
Homologene: 130558
Tmprss11b
Name: transmembrane protease, serine 11B
Synonyms: Tmprss11bnl, 9930019B18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319875
Homologene: 64599
Sox7
Name: SRY (sex determining region Y)-box 7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20680
VEGA: 14
Homologene: 7949
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 171580
Homologene: 11246
Zfp28
Name: zinc finger protein 28
Synonyms: 2810438M17Rik, Zfp-28, mkr-5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22690
Homologene: 69047
Smyd4
Name: SET and MYND domain containing 4
Synonyms: G430029E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319822
Homologene: 35098
Mtcl3
Name: MTCL family member 3
Synonyms: Soga3, 6330407J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67412
VEGA: 10
Homologene: 28227
Pdia2
Name: protein disulfide isomerase associated 2
Synonyms: 1810041F13Rik, Pdipl, Pdip
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69191
Homologene: 55994
Dcun1d1
Name: defective in cullin neddylation 1 domain containing 1
Synonyms: Rp42, Tes3, SCCRO, pTes3, DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114893
Homologene: 10773
Zscan4b
Name: zinc finger and SCAN domain containing 4B
Synonyms: EG665780
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665780
Homologene: 85986
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Mup21
Name: major urinary protein 21
Synonyms: Gm11208
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381531
Homologene: 74304
Orai2
Name: ORAI calcium release-activated calcium modulator 2
Synonyms: A730041O15Rik, Tmem142b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269717
Homologene: 32799
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: prolactin-like, Pl-2, PL, mPL-II, Pl2, mplII, Csh2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18776
Homologene: 7476
Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms: 2610044A17Rik, Gwt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70325
Homologene: 6243
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 194126
Homologene: 82382
Or2z9
Name: olfactory receptor family 2 subfamily Z member 9
Synonyms: Olfr373, MOR282-2, MOR282-1, GA_x6K02T2NUPS-231686-232630
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258532
Homologene: 17287
Pnlip
Name: pancreatic lipase
Synonyms: PTL, pancreatic triglyceride lipase, 1810007A24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Nudt21
Name: nudix hydrolase 21
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 21, 5730530J16Rik, Cpsf5, 25kDa, 3110048P04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68219
Homologene: 5090
Cpeb4
Name: cytoplasmic polyadenylation element binding protein 4
Synonyms: 4930447D24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67579
Homologene: 12736
Rnaset2b
Name: ribonuclease T2B
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68195
VEGA: 17
Homologene: 31190
Or51f1
Name: olfactory receptor family 51 subfamily F member 1
Synonyms: GA_x6K02T2PBJ9-5560696-5559746, Olfr566, MOR14-7P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258168
Homologene: 133721
Or10g9
Name: olfactory receptor family 10 subfamily G member 9
Synonyms: MOR223-1, Olfr979, GA_x6K02T2PVTD-33699706-33698771
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259112
VEGA: 9
Homologene: 81556
4933434E20Rik
Name: RIKEN cDNA 4933434E20 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99650
Homologene: 41041
Frrs1l
Name: ferric-chelate reductase 1 like
Synonyms: 6430704M03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230235
HGNC: HGNC:1362
Homologene: 87703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 60,237,151 bp
  • A to T, chromosome 1 at 75,188,092 bp
  • C to T, chromosome 1 at 166,127,107 bp
  • T to G, chromosome 2 at 87,896,411 bp
  • T to C, chromosome 2 at 125,466,674 bp
  • C to T, chromosome 2 at 146,045,470 bp
  • A to G, chromosome 3 at 35,897,791 bp
  • G to A, chromosome 3 at 69,317,711 bp
  • T to C, chromosome 3 at 90,061,714 bp
  • T to A, chromosome 3 at 94,984,577 bp
  • C to T, chromosome 3 at 96,164,538 bp
  • T to A, chromosome 3 at 106,491,263 bp
  • C to T, chromosome 3 at 116,881,777 bp
  • G to A, chromosome 4 at 43,545,922 bp
  • A to G, chromosome 4 at 56,968,230 bp
  • A to G, chromosome 4 at 62,150,231 bp
  • A to T, chromosome 4 at 123,506,337 bp
  • T to C, chromosome 4 at 144,160,231 bp
  • A to T, chromosome 5 at 65,666,227 bp
  • T to A, chromosome 5 at 86,664,314 bp
  • G to T, chromosome 5 at 121,445,329 bp
  • T to A, chromosome 5 at 136,150,583 bp
  • C to A, chromosome 6 at 29,562,876 bp
  • C to T, chromosome 6 at 67,356,633 bp
  • T to C, chromosome 6 at 119,057,211 bp
  • C to T, chromosome 6 at 126,039,497 bp
  • T to A, chromosome 6 at 144,155,033 bp
  • G to T, chromosome 7 at 6,383,594 bp
  • A to G, chromosome 7 at 10,900,940 bp
  • C to A, chromosome 7 at 49,461,924 bp
  • T to A, chromosome 7 at 82,681,444 bp
  • T to C, chromosome 7 at 101,990,599 bp
  • T to A, chromosome 7 at 102,856,499 bp
  • T to C, chromosome 7 at 109,143,612 bp
  • C to A, chromosome 7 at 118,984,259 bp
  • A to T, chromosome 8 at 69,743,109 bp
  • T to C, chromosome 8 at 72,099,949 bp
  • A to T, chromosome 8 at 94,019,599 bp
  • A to G, chromosome 8 at 109,940,153 bp
  • T to C, chromosome 9 at 20,967,942 bp
  • A to T, chromosome 9 at 40,000,810 bp
  • T to A, chromosome 9 at 111,177,457 bp
  • A to T, chromosome 10 at 7,867,581 bp
  • A to G, chromosome 10 at 29,197,244 bp
  • T to C, chromosome 10 at 41,479,776 bp
  • A to T, chromosome 11 at 31,931,417 bp
  • T to C, chromosome 11 at 59,055,616 bp
  • C to A, chromosome 11 at 73,164,866 bp
  • A to G, chromosome 11 at 75,390,256 bp
  • G to A, chromosome 11 at 84,877,759 bp
  • T to A, chromosome 11 at 94,432,557 bp
  • C to T, chromosome 11 at 102,046,941 bp
  • C to T, chromosome 12 at 109,595,238 bp
  • T to A, chromosome 13 at 27,242,490 bp
  • A to G, chromosome 13 at 93,708,846 bp
  • A to G, chromosome 14 at 63,947,842 bp
  • T to A, chromosome 15 at 10,493,281 bp
  • A to G, chromosome 15 at 102,982,161 bp
  • C to T, chromosome 17 at 6,998,028 bp
  • T to A, chromosome 17 at 19,522,034 bp
  • T to C, chromosome 17 at 26,197,660 bp
  • T to C, chromosome 17 at 37,659,512 bp
  • T to A, chromosome 19 at 58,681,702 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7312 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045410-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.