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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7316Btlr/Mmmh
Stock Number:
045413-MU
Citation ID:
RRID:MMRRC_045413-MU
Other Names:
R7316 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Ntsr1
Name: neurotensin receptor 1
Synonyms: NT-1R, Ntsr1, NTR-1, NTR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261

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Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112

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Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461

Additional Resources
IMPC
Google
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Gene Ontology
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Mouse Mine
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Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966

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IMPC
Google
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Gene Ontology
BioGPS
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Nkx2-1
Name: NK2 homeobox 1
Synonyms: thyroid-specific enhancer-binding protein, T/EBP, tinman, Ttf-1, thyroid transcription factor-1, Titf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21869
Homologene: 2488

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Zfp568
Name: zinc finger protein 568
Synonyms: LOC381866, chato
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243905
Homologene: 136307

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,418,116 bp
  • T to C, chromosome 1 at 43,970,431 bp
  • C to T, chromosome 1 at 128,359,508 bp
  • T to C, chromosome 1 at 138,064,771 bp
  • A to G, chromosome 1 at 150,732,946 bp
  • A to G, chromosome 1 at 166,663,646 bp
  • A to T, chromosome 1 at 174,070,161 bp
  • A to T, chromosome 2 at 4,936,044 bp
  • G to A, chromosome 2 at 34,704,669 bp
  • A to T, chromosome 2 at 52,271,438 bp
  • A to T, chromosome 2 at 75,980,857 bp
  • A to T, chromosome 2 at 76,766,913 bp
  • A to G, chromosome 2 at 76,862,165 bp
  • A to C, chromosome 2 at 82,989,691 bp
  • A to T, chromosome 2 at 120,728,332 bp
  • A to C, chromosome 2 at 180,500,752 bp
  • T to C, chromosome 3 at 19,972,752 bp
  • G to A, chromosome 3 at 90,061,713 bp
  • A to G, chromosome 4 at 9,537,746 bp
  • A to T, chromosome 4 at 19,425,599 bp
  • T to A, chromosome 4 at 57,019,867 bp
  • T to A, chromosome 4 at 58,068,763 bp
  • T to A, chromosome 4 at 59,017,693 bp
  • T to C, chromosome 4 at 72,118,292 bp
  • A to G, chromosome 4 at 108,250,502 bp
  • A to T, chromosome 4 at 141,477,054 bp
  • G to T, chromosome 5 at 64,335,277 bp
  • A to G, chromosome 5 at 107,433,113 bp
  • A to G, chromosome 6 at 29,286,102 bp
  • C to T, chromosome 6 at 34,103,256 bp
  • T to A, chromosome 6 at 92,154,463 bp
  • T to C, chromosome 6 at 128,513,773 bp
  • T to A, chromosome 6 at 135,309,832 bp
  • T to C, chromosome 6 at 136,401,278 bp
  • T to C, chromosome 6 at 149,326,638 bp
  • C to A, chromosome 7 at 6,155,524 bp
  • G to C, chromosome 7 at 16,435,335 bp
  • A to T, chromosome 7 at 27,910,438 bp
  • A to T, chromosome 7 at 30,022,256 bp
  • A to G, chromosome 7 at 87,975,265 bp
  • A to T, chromosome 7 at 99,876,216 bp
  • A to T, chromosome 7 at 105,090,900 bp
  • A to T, chromosome 7 at 109,030,171 bp
  • A to C, chromosome 7 at 139,256,224 bp
  • C to A, chromosome 8 at 3,604,648 bp
  • G to T, chromosome 8 at 60,526,634 bp
  • T to A, chromosome 8 at 70,779,788 bp
  • A to G, chromosome 8 at 92,840,410 bp
  • T to C, chromosome 9 at 58,197,967 bp
  • T to A, chromosome 9 at 59,987,359 bp
  • A to T, chromosome 9 at 75,269,638 bp
  • A to T, chromosome 9 at 108,209,502 bp
  • C to A, chromosome 10 at 79,965,225 bp
  • T to C, chromosome 10 at 80,639,853 bp
  • A to T, chromosome 10 at 80,717,859 bp
  • C to A, chromosome 10 at 80,894,979 bp
  • A to T, chromosome 10 at 88,400,710 bp
  • T to A, chromosome 10 at 127,689,343 bp
  • C to A, chromosome 11 at 3,726,431 bp
  • T to C, chromosome 11 at 3,912,584 bp
  • A to T, chromosome 11 at 55,286,067 bp
  • A to T, chromosome 11 at 69,186,238 bp
  • A to T, chromosome 11 at 69,345,568 bp
  • G to A, chromosome 11 at 107,073,109 bp
  • A to T, chromosome 11 at 107,110,914 bp
  • A to G, chromosome 12 at 11,241,469 bp
  • A to G, chromosome 12 at 55,304,644 bp
  • T to C, chromosome 12 at 56,534,798 bp
  • T to C, chromosome 12 at 81,419,724 bp
  • T to C, chromosome 12 at 81,995,549 bp
  • C to T, chromosome 12 at 98,658,612 bp
  • T to C, chromosome 14 at 24,490,689 bp
  • G to T, chromosome 14 at 37,068,858 bp
  • A to T, chromosome 14 at 51,414,255 bp
  • A to T, chromosome 14 at 66,862,595 bp
  • A to T, chromosome 14 at 77,720,858 bp
  • A to T, chromosome 15 at 9,461,802 bp
  • T to C, chromosome 15 at 63,858,402 bp
  • A to T, chromosome 15 at 77,132,729 bp
  • A to G, chromosome 15 at 80,249,397 bp
  • G to A, chromosome 15 at 98,740,993 bp
  • A to T, chromosome 15 at 100,001,017 bp
  • T to A, chromosome 16 at 32,407,648 bp
  • T to A, chromosome 16 at 46,069,653 bp
  • G to A, chromosome 17 at 24,894,866 bp
  • T to A, chromosome 17 at 28,814,686 bp
  • G to C, chromosome 17 at 34,469,057 bp
  • A to G, chromosome 17 at 37,590,135 bp
  • A to G, chromosome 17 at 56,765,551 bp
  • A to T, chromosome 17 at 74,604,494 bp
  • T to C, chromosome 18 at 37,808,448 bp
  • T to C, chromosome 18 at 61,307,838 bp
  • T to C, chromosome 19 at 4,114,793 bp
  • C to T, chromosome 19 at 6,966,385 bp
  • T to A, chromosome 19 at 11,001,996 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7316 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045413-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.