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Strain Name:
C57BL/6J-MtgxR7342Btlr/Mmmh
Stock Number:
045432-MU
Citation ID:
RRID:MMRRC_045432-MU
Other Names:
R7342 (G1)
Major Collection:

Strain Information

Ptf1a
Name: pancreas specific transcription factor, 1a
Synonyms: PTF1-p48, bHLHa29
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19213
Homologene: 10304
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ctbp2
Name: C-terminal binding protein 2
Synonyms: D7Ertd45e, Ribeye, Gtrgeo6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: RBBP1L1, SAP180, BRCAA1, Rbp1l1, 6720480E17Rik, 6330417L24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,162,325 bp
  • C to A, chromosome 1 at 57,885,947 bp
  • A to G, chromosome 1 at 116,060,122 bp
  • C to T, chromosome 1 at 181,825,621 bp
  • A to G, chromosome 2 at 19,447,166 bp
  • A to T, chromosome 2 at 28,560,637 bp
  • A to T, chromosome 2 at 52,281,667 bp
  • A to G, chromosome 2 at 69,479,290 bp
  • T to C, chromosome 2 at 180,736,762 bp
  • T to A, chromosome 3 at 14,554,371 bp
  • G to T, chromosome 3 at 88,965,997 bp
  • T to A, chromosome 3 at 129,875,132 bp
  • T to C, chromosome 4 at 43,258,703 bp
  • T to A, chromosome 4 at 108,091,321 bp
  • T to C, chromosome 4 at 123,382,124 bp
  • A to T, chromosome 4 at 143,896,950 bp
  • A to C, chromosome 4 at 149,214,090 bp
  • G to A, chromosome 4 at 149,629,430 bp
  • T to C, chromosome 4 at 156,350,843 bp
  • T to C, chromosome 5 at 27,714,554 bp
  • C to T, chromosome 5 at 31,536,290 bp
  • T to A, chromosome 5 at 92,348,170 bp
  • T to A, chromosome 5 at 112,327,972 bp
  • C to T, chromosome 5 at 113,614,293 bp
  • C to A, chromosome 5 at 114,258,699 bp
  • A to G, chromosome 5 at 124,646,736 bp
  • T to A, chromosome 6 at 3,691,536 bp
  • G to A, chromosome 6 at 72,309,875 bp
  • G to C, chromosome 6 at 72,616,278 bp
  • T to A, chromosome 6 at 83,814,826 bp
  • G to T, chromosome 6 at 134,450,818 bp
  • A to T, chromosome 6 at 146,327,187 bp
  • A to G, chromosome 7 at 35,334,346 bp
  • G to A, chromosome 7 at 86,336,087 bp
  • T to G, chromosome 7 at 120,029,985 bp
  • T to C, chromosome 7 at 123,327,244 bp
  • T to C, chromosome 7 at 133,014,312 bp
  • T to C, chromosome 7 at 139,986,391 bp
  • T to C, chromosome 8 at 70,895,398 bp
  • T to C, chromosome 8 at 71,355,774 bp
  • G to A, chromosome 8 at 124,433,970 bp
  • A to G, chromosome 9 at 38,292,278 bp
  • A to T, chromosome 9 at 90,074,987 bp
  • T to C, chromosome 10 at 84,374,967 bp
  • A to T, chromosome 10 at 119,211,787 bp
  • T to C, chromosome 11 at 76,730,207 bp
  • T to G, chromosome 11 at 101,417,192 bp
  • A to T, chromosome 12 at 24,558,344 bp
  • A to G, chromosome 12 at 38,100,433 bp
  • A to G, chromosome 12 at 58,213,670 bp
  • A to G, chromosome 12 at 113,306,430 bp
  • A to C, chromosome 13 at 14,136,219 bp
  • A to T, chromosome 13 at 100,189,356 bp
  • G to T, chromosome 13 at 112,669,591 bp
  • T to C, chromosome 14 at 12,237,151 bp
  • T to C, chromosome 14 at 75,906,877 bp
  • T to A, chromosome 14 at 118,994,972 bp
  • G to A, chromosome 15 at 10,551,497 bp
  • A to G, chromosome 15 at 88,826,407 bp
  • C to A, chromosome 16 at 14,465,169 bp
  • A to G, chromosome 17 at 21,427,752 bp
  • T to C, chromosome 17 at 56,104,608 bp
  • T to C, chromosome 17 at 56,715,644 bp
  • G to A, chromosome 19 at 5,039,658 bp
  • G to A, chromosome 19 at 11,590,073 bp
  • A to T, chromosome 19 at 11,763,223 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045432-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.