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Strain Name:
C57BL/6J-MtgxR7371Btlr/Mmmh
Stock Number:
045454-MU
Citation ID:
RRID:MMRRC_045454-MU
Other Names:
R7371 (G1)
Major Collection:

Strain Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Cdh3
Name: cadherin 3
Synonyms: P-cadherin, Cadp, Pcad
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Satb1
Name: special AT-rich sequence binding protein 1
Synonyms: 2610306G12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20230
Homologene: 2232
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, 9330177P20Rik, Zfp258
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100177
Homologene: 5186
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 44,061,377 bp
  • A to G, chromosome 1 at 58,263,854 bp
  • GGAAGAAG to GGAAGAAGAAG, chromosome 1 at 86,529,539 bp
  • A to G, chromosome 1 at 119,472,399 bp
  • A to G, chromosome 1 at 162,954,227 bp
  • T to C, chromosome 1 at 181,626,885 bp
  • C to G, chromosome 1 at 185,251,068 bp
  • A to G, chromosome 2 at 5,961,040 bp
  • T to A, chromosome 2 at 11,643,020 bp
  • A to T, chromosome 2 at 23,140,573 bp
  • T to C, chromosome 2 at 26,441,722 bp
  • T to A, chromosome 2 at 34,717,373 bp
  • T to C, chromosome 2 at 73,679,890 bp
  • A to C, chromosome 2 at 110,884,849 bp
  • A to T, chromosome 2 at 111,193,481 bp
  • G to A, chromosome 2 at 146,347,126 bp
  • A to G, chromosome 2 at 173,234,419 bp
  • T to C, chromosome 3 at 83,046,052 bp
  • T to C, chromosome 3 at 87,088,422 bp
  • T to C, chromosome 3 at 97,757,271 bp
  • T to A, chromosome 3 at 131,293,495 bp
  • A to G, chromosome 3 at 145,343,698 bp
  • A to C, chromosome 4 at 19,425,575 bp
  • G to T, chromosome 4 at 41,195,779 bp
  • A to G, chromosome 4 at 62,321,056 bp
  • T to A, chromosome 4 at 127,104,313 bp
  • T to C, chromosome 4 at 143,438,776 bp
  • A to G, chromosome 5 at 105,342,105 bp
  • A to T, chromosome 5 at 129,543,241 bp
  • G to A, chromosome 5 at 129,605,772 bp
  • T to A, chromosome 6 at 42,927,535 bp
  • T to A, chromosome 6 at 119,308,709 bp
  • G to A, chromosome 7 at 3,319,553 bp
  • T to C, chromosome 7 at 11,307,324 bp
  • A to C, chromosome 7 at 16,723,727 bp
  • T to C, chromosome 7 at 19,792,903 bp
  • A to T, chromosome 7 at 23,418,423 bp
  • T to A, chromosome 7 at 25,474,720 bp
  • C to A, chromosome 7 at 28,423,501 bp
  • T to A, chromosome 7 at 29,172,180 bp
  • T to C, chromosome 7 at 45,678,610 bp
  • T to C, chromosome 7 at 73,966,927 bp
  • A to G, chromosome 7 at 105,143,879 bp
  • T to A, chromosome 7 at 111,033,807 bp
  • T to C, chromosome 8 at 8,660,524 bp
  • T to A, chromosome 8 at 83,271,261 bp
  • A to G, chromosome 8 at 93,057,354 bp
  • T to A, chromosome 8 at 106,552,477 bp
  • T to A, chromosome 8 at 122,413,021 bp
  • C to A, chromosome 8 at 124,028,269 bp
  • T to A, chromosome 8 at 125,935,065 bp
  • A to C, chromosome 9 at 14,727,433 bp
  • A to G, chromosome 9 at 21,757,368 bp
  • T to C, chromosome 9 at 63,146,887 bp
  • T to C, chromosome 9 at 121,668,555 bp
  • T to C, chromosome 10 at 83,365,816 bp
  • A to T, chromosome 10 at 85,147,919 bp
  • A to T, chromosome 10 at 115,151,111 bp
  • T to C, chromosome 11 at 20,726,836 bp
  • A to T, chromosome 11 at 60,718,264 bp
  • T to C, chromosome 11 at 76,846,611 bp
  • A to T, chromosome 11 at 100,135,560 bp
  • A to G, chromosome 11 at 105,798,596 bp
  • C to T, chromosome 11 at 114,987,360 bp
  • T to C, chromosome 11 at 115,998,080 bp
  • G to T, chromosome 12 at 65,158,594 bp
  • A to C, chromosome 12 at 81,560,290 bp
  • G to A, chromosome 12 at 103,689,827 bp
  • A to T, chromosome 12 at 107,989,491 bp
  • A to G, chromosome 13 at 9,592,749 bp
  • A to T, chromosome 13 at 95,700,338 bp
  • G to A, chromosome 14 at 23,494,570 bp
  • G to A, chromosome 14 at 42,792,896 bp
  • A to T, chromosome 14 at 49,961,106 bp
  • T to A, chromosome 15 at 11,845,290 bp
  • T to A, chromosome 15 at 61,988,182 bp
  • T to A, chromosome 15 at 64,699,218 bp
  • T to C, chromosome 15 at 76,600,575 bp
  • C to T, chromosome 15 at 86,030,674 bp
  • C to T, chromosome 15 at 86,135,406 bp
  • C to A, chromosome 15 at 89,379,162 bp
  • T to A, chromosome 15 at 101,920,388 bp
  • T to C, chromosome 16 at 55,905,320 bp
  • C to A, chromosome 17 at 51,782,980 bp
  • A to T, chromosome 17 at 56,650,801 bp
  • A to G, chromosome 18 at 22,130,138 bp
  • C to T, chromosome 19 at 10,531,839 bp
  • A to G, chromosome 19 at 17,119,370 bp
  • A to T, chromosome 19 at 22,902,193 bp
  • T to A, chromosome 19 at 46,699,618 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7371 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045454-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.