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Strain Name:
C57BL/6J-MtgxR7373Btlr/Mmmh
Stock Number:
045456-MU
Citation ID:
RRID:MMRRC_045456-MU
Other Names:
R7373 (G1)
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik, D630049N15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Aldh7a1
Name: aldehyde dehydrogenase family 7, member A1
Synonyms: Atq1, D18Wsu181e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110695
HGNC: HGNC:877
Homologene: 913
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77683
Homologene: 11698
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Lims1
Name: LIM and senescent cell antigen-like domains 1
Synonyms: 2310016J22Rik, 4921524A02Rik, Lims1l, PINCH1, C430041B13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110829
HGNC: HGNC:6616
Homologene: 68428
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 34,188,391 bp
  • A to G, chromosome 1 at 82,737,117 bp
  • A to T, chromosome 1 at 116,580,637 bp
  • C to A, chromosome 1 at 153,425,240 bp
  • T to C, chromosome 1 at 184,730,865 bp
  • A to G, chromosome 2 at 24,919,573 bp
  • A to G, chromosome 2 at 30,382,071 bp
  • G to T, chromosome 2 at 69,500,692 bp
  • T to A, chromosome 2 at 112,021,442 bp
  • G to T, chromosome 2 at 116,886,745 bp
  • A to T, chromosome 2 at 125,757,271 bp
  • A to T, chromosome 3 at 95,576,317 bp
  • A to C, chromosome 3 at 101,877,897 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • T to A, chromosome 4 at 154,889,208 bp
  • C to A, chromosome 5 at 33,727,690 bp
  • C to A, chromosome 6 at 126,834,458 bp
  • A to T, chromosome 6 at 131,678,354 bp
  • T to C, chromosome 7 at 4,793,603 bp
  • A to T, chromosome 7 at 15,397,220 bp
  • A to G, chromosome 7 at 28,294,632 bp
  • C to T, chromosome 7 at 41,837,788 bp
  • T to A, chromosome 7 at 68,195,078 bp
  • T to A, chromosome 7 at 102,714,099 bp
  • T to C, chromosome 8 at 15,992,713 bp
  • A to G, chromosome 8 at 45,026,665 bp
  • A to T, chromosome 8 at 64,051,357 bp
  • A to T, chromosome 8 at 119,730,252 bp
  • C to T, chromosome 8 at 125,808,027 bp
  • C to A, chromosome 9 at 64,897,269 bp
  • G to A, chromosome 9 at 83,854,877 bp
  • T to C, chromosome 9 at 108,113,484 bp
  • C to T, chromosome 9 at 123,177,900 bp
  • T to C, chromosome 10 at 44,004,140 bp
  • T to C, chromosome 10 at 58,409,620 bp
  • G to T, chromosome 10 at 107,901,251 bp
  • G to A, chromosome 11 at 50,795,435 bp
  • A to G, chromosome 11 at 73,240,673 bp
  • C to A, chromosome 11 at 97,038,880 bp
  • C to T, chromosome 11 at 100,708,566 bp
  • C to T, chromosome 11 at 113,699,831 bp
  • T to C, chromosome 11 at 115,928,372 bp
  • A to T, chromosome 11 at 120,813,976 bp
  • A to T, chromosome 12 at 37,108,798 bp
  • A to G, chromosome 12 at 119,202,475 bp
  • T to C, chromosome 13 at 55,808,132 bp
  • T to A, chromosome 15 at 12,140,559 bp
  • T to C, chromosome 15 at 59,317,809 bp
  • T to C, chromosome 15 at 91,700,004 bp
  • T to A, chromosome 15 at 102,280,992 bp
  • T to C, chromosome 16 at 4,955,871 bp
  • G to T, chromosome 16 at 26,360,856 bp
  • G to A, chromosome 16 at 96,205,835 bp
  • T to A, chromosome 17 at 8,942,992 bp
  • A to T, chromosome 17 at 18,824,686 bp
  • T to C, chromosome 17 at 30,767,965 bp
  • G to T, chromosome 17 at 57,509,406 bp
  • G to A, chromosome 18 at 56,542,317 bp
  • A to G, chromosome 19 at 6,066,646 bp
  • T to C, chromosome 19 at 34,935,671 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7373 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045456-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.