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Strain Name:
C57BL/6J-MtgxR7384Btlr/Mmmh
Stock Number:
045466-MU
Citation ID:
RRID:MMRRC_045466-MU
Other Names:
R7384 (G1)
Major Collection:

Strain Information

Kif3a
Name: kinesin family member 3A
Synonyms: kinesin-II subunit, Kns3, Kif3, Kifl, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16568
HGNC: HGNC:6319
Homologene: 38266
Traf4
Name: TNF receptor associated factor 4
Synonyms: CART1, A530032M13Rik, msp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22032
Homologene: 3173
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra-5, Acra5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Faah
Name: fatty acid amide hydrolase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14073
HGNC: HGNC:3553
Homologene: 68184
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,229,512 bp
  • A to T, chromosome 1 at 39,394,098 bp
  • T to A, chromosome 1 at 40,282,261 bp
  • T to A, chromosome 1 at 40,612,251 bp
  • C to A, chromosome 1 at 58,752,576 bp
  • T to G, chromosome 1 at 72,658,465 bp
  • C to T, chromosome 1 at 165,576,608 bp
  • T to C, chromosome 1 at 188,400,163 bp
  • T to C, chromosome 2 at 14,134,430 bp
  • C to T, chromosome 2 at 120,371,523 bp
  • A to T, chromosome 3 at 108,463,468 bp
  • A to G, chromosome 3 at 116,117,228 bp
  • A to G, chromosome 3 at 122,825,000 bp
  • A to G, chromosome 3 at 145,933,040 bp
  • T to A, chromosome 3 at 153,888,748 bp
  • G to T, chromosome 4 at 116,005,167 bp
  • T to C, chromosome 4 at 129,181,909 bp
  • T to A, chromosome 4 at 144,780,621 bp
  • A to T, chromosome 4 at 155,610,632 bp
  • T to A, chromosome 5 at 37,173,207 bp
  • A to T, chromosome 5 at 108,446,060 bp
  • T to G, chromosome 5 at 115,061,641 bp
  • A to T, chromosome 6 at 42,471,323 bp
  • A to G, chromosome 6 at 84,114,105 bp
  • A to T, chromosome 6 at 85,348,330 bp
  • A to G, chromosome 6 at 125,173,401 bp
  • T to C, chromosome 7 at 15,939,495 bp
  • T to A, chromosome 7 at 18,818,660 bp
  • G to A, chromosome 7 at 26,449,538 bp
  • T to C, chromosome 7 at 28,615,088 bp
  • A to G, chromosome 7 at 30,527,271 bp
  • G to A, chromosome 7 at 97,696,781 bp
  • G to C, chromosome 7 at 126,764,291 bp
  • T to C, chromosome 8 at 22,022,315 bp
  • G to A, chromosome 8 at 85,050,119 bp
  • A to G, chromosome 8 at 94,389,377 bp
  • A to C, chromosome 8 at 99,230,506 bp
  • A to C, chromosome 8 at 104,442,543 bp
  • A to G, chromosome 9 at 20,212,745 bp
  • A to C, chromosome 9 at 21,739,794 bp
  • G to A, chromosome 9 at 46,241,474 bp
  • T to C, chromosome 9 at 51,119,113 bp
  • T to C, chromosome 9 at 55,004,833 bp
  • AGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGA, chromosome 9 at 65,371,750 bp
  • A to G, chromosome 9 at 106,450,141 bp
  • T to A, chromosome 9 at 122,176,343 bp
  • A to T, chromosome 10 at 44,458,507 bp
  • T to A, chromosome 10 at 58,269,964 bp
  • A to T, chromosome 10 at 78,209,384 bp
  • A to T, chromosome 10 at 79,709,797 bp
  • G to A, chromosome 10 at 80,312,624 bp
  • C to A, chromosome 11 at 9,333,257 bp
  • A to T, chromosome 11 at 49,810,990 bp
  • T to A, chromosome 11 at 53,578,854 bp
  • A to T, chromosome 11 at 67,224,375 bp
  • T to C, chromosome 11 at 69,851,621 bp
  • A to G, chromosome 11 at 78,074,101 bp
  • A to G, chromosome 11 at 78,160,791 bp
  • G to T, chromosome 11 at 95,753,004 bp
  • C to T, chromosome 12 at 24,653,743 bp
  • G to T, chromosome 12 at 33,433,632 bp
  • A to G, chromosome 12 at 35,995,924 bp
  • T to C, chromosome 12 at 83,992,667 bp
  • G to T, chromosome 12 at 103,171,578 bp
  • A to G, chromosome 13 at 23,136,725 bp
  • A to G, chromosome 13 at 24,882,605 bp
  • G to T, chromosome 13 at 55,402,934 bp
  • G to A, chromosome 13 at 74,172,156 bp
  • A to C, chromosome 13 at 76,150,735 bp
  • A to T, chromosome 13 at 93,393,039 bp
  • T to A, chromosome 13 at 120,035,261 bp
  • T to A, chromosome 14 at 4,558,271 bp
  • A to G, chromosome 14 at 44,124,877 bp
  • G to A, chromosome 14 at 52,181,162 bp
  • A to G, chromosome 14 at 53,538,536 bp
  • A to G, chromosome 14 at 103,276,393 bp
  • T to A, chromosome 15 at 78,561,931 bp
  • A to T, chromosome 15 at 96,420,387 bp
  • A to T, chromosome 16 at 28,828,912 bp
  • T to C, chromosome 16 at 37,029,418 bp
  • A to G, chromosome 16 at 85,899,826 bp
  • G to A, chromosome 17 at 3,532,611 bp
  • A to G, chromosome 17 at 34,718,518 bp
  • A to G, chromosome 17 at 56,257,537 bp
  • A to C, chromosome 18 at 61,698,390 bp
  • T to C, chromosome 19 at 6,261,677 bp
  • T to C, chromosome 19 at 12,269,076 bp
  • T to A, chromosome 19 at 46,004,017 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7384 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045466-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.