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Strain Name:
C57BL/6J-MtgxR7390Btlr/Mmmh
Stock Number:
045472-MU
Citation ID:
RRID:MMRRC_045472-MU
Other Names:
R7390 (G1)
Major Collection:

Strain Information

Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: Su(Fu), 2810026F04Rik, b2b273Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24069
Homologene: 9262
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Bmp7
Name: bone morphogenetic protein 7
Synonyms: osteogenic protein 1, OP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12162
HGNC: HGNC:1074
Homologene: 20410
Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, D030049L12Rik, b2b2679Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Dpagt1
Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Synonyms: GPT, Dpagt2, Gnpta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13478
VEGA: 9
HGNC: HGNC:2995
Homologene: 1058
Pkp4
Name: plakophilin 4
Synonyms: p0071, Armrp, 5031422I09Rik, 9430019K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Lars1
Name: leucyl-tRNA synthetase 1
Synonyms: 3110009L02Rik, 2310045K21Rik, Lars
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 84,929,466 bp
  • T to C, chromosome 1 at 135,584,918 bp
  • T to C, chromosome 1 at 155,866,087 bp
  • T to G, chromosome 1 at 172,541,358 bp
  • A to G, chromosome 2 at 32,288,190 bp
  • G to A, chromosome 2 at 59,310,140 bp
  • T to C, chromosome 2 at 146,001,882 bp
  • A to G, chromosome 2 at 153,889,806 bp
  • C to T, chromosome 2 at 172,870,205 bp
  • A to T, chromosome 3 at 15,543,040 bp
  • T to C, chromosome 3 at 95,138,484 bp
  • A to G, chromosome 4 at 83,818,067 bp
  • G to C, chromosome 4 at 123,208,479 bp
  • C to T, chromosome 4 at 125,649,739 bp
  • T to A, chromosome 4 at 137,539,179 bp
  • T to C, chromosome 5 at 11,344,912 bp
  • T to C, chromosome 5 at 14,682,010 bp
  • T to C, chromosome 5 at 90,282,920 bp
  • C to T, chromosome 5 at 100,543,875 bp
  • G to T, chromosome 5 at 104,175,686 bp
  • T to C, chromosome 5 at 144,129,443 bp
  • C to A, chromosome 7 at 5,453,987 bp
  • A to G, chromosome 7 at 7,479,852 bp
  • T to A, chromosome 7 at 119,144,612 bp
  • T to C, chromosome 8 at 44,952,474 bp
  • A to C, chromosome 8 at 70,452,849 bp
  • A to C, chromosome 8 at 93,044,841 bp
  • C to T, chromosome 8 at 94,623,185 bp
  • T to A, chromosome 9 at 4,330,424 bp
  • A to T, chromosome 9 at 30,911,108 bp
  • G to A, chromosome 9 at 44,332,022 bp
  • C to T, chromosome 9 at 71,645,649 bp
  • A to G, chromosome 9 at 94,537,383 bp
  • A to C, chromosome 9 at 97,359,129 bp
  • T to C, chromosome 9 at 99,010,980 bp
  • T to A, chromosome 9 at 102,731,690 bp
  • G to A, chromosome 9 at 107,584,967 bp
  • C to T, chromosome 10 at 7,702,095 bp
  • A to G, chromosome 10 at 41,634,048 bp
  • G to A, chromosome 10 at 79,780,031 bp
  • G to A, chromosome 10 at 80,834,629 bp
  • T to A, chromosome 11 at 67,700,057 bp
  • C to T, chromosome 11 at 70,218,971 bp
  • T to A, chromosome 11 at 72,456,878 bp
  • G to T, chromosome 11 at 75,764,661 bp
  • A to T, chromosome 11 at 100,135,560 bp
  • T to C, chromosome 11 at 104,724,585 bp
  • C to T, chromosome 11 at 110,145,661 bp
  • A to G, chromosome 12 at 73,281,620 bp
  • T to C, chromosome 12 at 103,767,778 bp
  • T to C, chromosome 13 at 25,107,617 bp
  • A to T, chromosome 13 at 60,844,338 bp
  • G to A, chromosome 14 at 66,110,455 bp
  • T to A, chromosome 15 at 81,008,820 bp
  • T to G, chromosome 15 at 89,549,312 bp
  • C to T, chromosome 16 at 17,722,762 bp
  • A to G, chromosome 16 at 56,732,844 bp
  • G to T, chromosome 16 at 78,547,688 bp
  • A to T, chromosome 17 at 18,305,067 bp
  • A to T, chromosome 17 at 26,068,152 bp
  • G to A, chromosome 17 at 36,869,881 bp
  • A to C, chromosome 17 at 83,846,652 bp
  • G to A, chromosome 17 at 88,549,530 bp
  • A to G, chromosome 18 at 42,210,018 bp
  • A to G, chromosome 19 at 9,003,205 bp
  • A to T, chromosome 19 at 27,424,242 bp
  • A to T, chromosome 19 at 30,099,914 bp
  • A to G, chromosome 19 at 41,120,169 bp
  • G to A, chromosome 19 at 46,450,669 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7390 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045472-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.